Correspondence Regarding the Consensus Statement from the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues.

We read the recent consensus statement from the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues regarding the suitability criteria for adult related donors outlined by Drs. Worel, Halter, and colleagues, published online on August 10, 2015. We suggest that in addition to the recommendations of the committee, it is extremely important to consider inherited predisposition to hematopoietic malignancies at the time of selection of any HLA-matched related donor for allogeneic stem cell transplantation. An especially notable group of donors are those found to have mild cytopenias. The recommendation proposed to allow donors with mild anemia (defined as 2 g/dL below anemia thresholds), mild neutropenia (defined as <1 109 neutrophils/L), mild lymphopenia (defined as <.5 109 lymphocytes/L), or mild thrombocytopenia (defined as between 100 and 130 109/L) absent a contraindication requires further comment. We and others have found that it is among this group of donors that workup will have the highest likelihood of finding unsuspected inherited hematopoietic malignancy syndromes [1]. Thus, we propose that without specific mention of when and how to evaluate

• Publication year

  2016

• Venue

  Biology of Blood and Marrow Transplantation

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.bbmt.2015.10.008PMID 26478096
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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