The Conserved Disulfide Bond within Domain II of Epstein-Barr Virus gH Has Divergent Roles in Membrane Fusion with Epithelial Cells and B Cells

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Virology

• Publication date

  2014-09-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.02272-14PMID 25231307PMCID PMC4248955
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Assembly and Architecture of the EBV B Cell Entry Triggering Complex

  2014cited by this paper
• Comparative Analysis of gO Isoforms Reveals that Strains of Human Cytomegalovirus Differ in the Ratio of gH/gL/gO and gH/gL/UL128-131 in the Virion Envelope

  2013cited by this paper
• The Large Groove Found in the gH/gL Structure Is an Important Functional Domain for Epstein-Barr Virus Fusion

  2013cited by this paper
• The KGD Motif of Epstein-Barr Virus gH/gL Is Bifunctional, Orchestrating Infection of B Cells and Epithelial Cells

  2012influential reference
• Structure-Based Mutational Analysis of the Highly Conserved Domain IV of Glycoprotein H of Pseudorabies Virus

  2012cited by this paper
• Fusing structure and function: a structural view of the herpesvirus entry machinery

  2011cited by this paper
• Fusion of Epstein-Barr Virus with Epithelial Cells Can Be Triggered by αvβ5 in Addition to αvβ6 and αvβ8, and Integrin Binding Triggers a Conformational Change in Glycoproteins gHgL

  2011cited by this paper
• Structure–function analysis of varicella-zoster virus glycoprotein H identifies domain-specific roles for fusion and skin tropism

  2011cited by this paper
• Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL

  2010influential reference
• Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody

  2010influential reference
• Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex

  2010influential reference
• Human cytomegalovirus tropism for endothelial/epithelial cells: scientific background and clinical implications

  2010cited by this paper
• Class III viral membrane fusion proteins.

  2009cited by this paper
• Jalview Version 2—a multiple sequence alignment editor and analysis workbench

  2009cited by this paper
• Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry.

  2009cited by this paper
• Fusion of epithelial cells by Epstein–Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins αvβ6 or αvβ8

  2009cited by this paper
• Functional Analysis of Glycoprotein L (gL) from Rhesus Lymphocryptovirus in Epstein-Barr Virus-Mediated Cell Fusion Indicates a Direct Role of gL in gB-Induced Membrane Fusion

  2009cited by this paper
• Structure of a trimeric variant of the Epstein–Barr virus glycoprotein B

  2009cited by this paper
• rtracklayer: an R package for interfacing with genome browsers

  2009cited by this paper
• Structure of tick anticoagulant peptide at 1.6 Å resolution complexed with bovine pancreatic trypsin inhibitor

  2008cited by this paper
• Compatibility of the gH homologues of Epstein-Barr virus and related lymphocryptoviruses.

  2007cited by this paper
• Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusion.

  2007cited by this paper
• Binding-Site Interactions between Epstein-Barr Virus Fusion Proteins gp42 and gH/gL Reveal a Peptide That Inhibits both Epithelial and B-Cell Membrane Fusion

  2007cited by this paper
• Crystal Structure of Glycoprotein B from Herpes Simplex Virus 1

  2006cited by this paper
• Soluble Epstein-Barr Virus Glycoproteins gH, gL, and gp42 Form a 1:1:1 Stable Complex That Acts Like Soluble gp42 in B-Cell Fusion but Not in Epithelial Cell Fusion

  2006cited by this paper
• Analysis of fusion using a virus-free cell fusion assay.

  2005cited by this paper
• Contribution of cysteine residues to the structure and function of herpes simplex virus gH/gL.

  2005cited by this paper
• The Amino Terminus of Epstein-Barr Virus Glycoprotein gH Is Important for Fusion with Epithelial and B Cells

  2005cited by this paper
• Mutations of Epstein-Barr Virus gH That Are Differentially Able To Support Fusion with B Cells or Epithelial Cells

  2005influential reference
• Disulfide bonds, their stereospecific environment and conservation in protein structures.

  2004cited by this paper
• Mutational Analyses of Epstein-Barr Virus Glycoprotein 42 Reveal Functional Domains Not Involved in Receptor Binding but Required for Membrane Fusion

  2004cited by this paper
• Use of gHgL for Attachment of Epstein-Barr Virus to Epithelial Cells Compromises Infection

  2004cited by this paper
• Complete Nucleotide Sequence of the Rhesus Lymphocryptovirus: Genetic Validation for an Epstein-Barr Virus Animal Model

  2002cited by this paper
• Alternate replication in B cells and epithelial cells switches tropism of Epstein–Barr virus

  2002cited by this paper
• Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1.

  2002cited by this paper
• Complete Genomic Sequence of an Epstein-Barr Virus-Related Herpesvirus Naturally Infecting a New World Primate: a Defining Point in the Evolution of Oncogenic Lymphocryptoviruses

  2002cited by this paper
• T-Coffee: A novel method for fast and accurate multiple sequence alignment.

  2000cited by this paper
• Epstein-Barr Virus gH Is Essential for Penetration of B Cells but Also Plays a Role in Attachment of Virus to Epithelial Cells

  2000cited by this paper
• Epstein-Barr Virus Uses Different Complexes of Glycoproteins gH and gL To Infect B Lymphocytes and Epithelial Cells

  1998cited by this paper
• Chaperone functions common to nonhomologous Epstein-Barr virus gL and Varicella-Zoster virus gL proteins

  1997cited by this paper
• Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes

  1997cited by this paper
• Structural Changes Are Associated with Soluble N-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation*

  1997cited by this paper
• The extracellular domain of the Epstein-Barr virus BZLF2 protein binds the HLA-DR beta chain and inhibits antigen presentation

  1996cited by this paper
• The Epstein-Barr virus (EBV) BZLF2 gene product associates with the gH and gL homologs of EBV and carries an epitope critical to infection of B cells but not of epithelial cells

  1995cited by this paper
• Epstein-Barr virus enters B cells and epithelial cells by different routes

  1992cited by this paper
• Induction of antibodies to the Epstein-Barr virus glycoprotein gp85 with a synthetic peptide corresponding to a sequence in the BXLF2 open reading frame

  1988cited by this paper

• Flipping the drug resistance switch

  2026cites this paper
• Epstein-Barr Virus (EBV)-Specific Humoral Immune Responses in Health and Disease.

  2025cites this paper
• EBV gL-gH344-Ferritin Nanoparticle Vaccine Elicits Robust Immune Responses in Mice

  2025cites this paper
• The use of peptides for deciphering the mechanism of EBV, HPV, and HCV invasion of human cells

  2025cites this paper
• Anti‐EBV antibodies: Roles in diagnosis, pathogenesis, and antiviral therapy

  2023cites this paper
• Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection

  2023cites this paper
• Glycoprotein B Antibodies Completely Neutralize EBV Infection of B Cells

  2022cites this paper
• A Neutralizing Antibody Targeting gH Provides Potent Protection against EBV Challenge In Vivo

  2022cites this paper
• A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus

  2021cites this paper
• Potential entry receptors for human γ-herpesvirus into epithelial cells: A plausible therapeutic target for viral infections

  2021cites this paper
• Epstein-Barr virus (EBV) is the causative agent of a wide range of diseases

  2020cites this paper
• Ephrin receptor A4 (EphA4) is a new Kaposi’s sarcoma-associated herpesvirus virus entry receptor

  2019cites this paper
• Epithelial cell infection by Epstein-Barr virus.

  2019cites this paper
• Ephrin Receptor A4 is a New Kaposi’s Sarcoma-Associated Herpesvirus Virus Entry Receptor

  2019cites this paper
• Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells.

  2019cites this paper
• An Antibody Targeting the Fusion Machinery Neutralizes Dual‐Tropic Infection and Defines a Site of Vulnerability on Epstein‐Barr Virus

  2018cites this paper
• Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies

  2017cites this paper
• The amino terminal subdomain of glycoprotein Gc of Schmallenberg virus: disulfide bonding and structural determinants of neutralization.

  2017cites this paper
• Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site

  2017cites this paper
• Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus

  2016influential citation
• Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function

  2015cites this paper
• Mutations in Pseudorabies Virus Glycoproteins gB, gD, and gH Functionally Compensate for the Absence of gL

  2015cites this paper
• Molecular detection of Babesia ovis in sheep and ticks using the gene encoding B. ovis surface protein D (BoSPD).

  2015cites this paper