Sensitivity of whole-blood T lymphocytes in individual patients to tacrolimus (FK 506): impact of interleukin-2 mRNA expression as surrogate measure of immunosuppressive effect.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Clinical Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1373/CLINCHEM.2003.024950PMID 14709642
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group.

  1997cited by this paper
• The mechanism of action of cyclosporin A and FK506.

  1996cited by this paper
• A prospective randomized trial of FK506-based immunosuppression after renal transplantation.

  1995cited by this paper
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  1995cited by this paper
• T-cell activation: integration of signals from the antigen receptor and costimulatory molecules.

  1995cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway.

  1989cited by this paper
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  1989cited by this paper
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