Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination With Omega-3 Fatty Acids

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Nutrition and Cancer

• Publication date

  2008-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/01635580802416703PMID 19003584
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Opposing Effects of n-6 and n-3 Polyunsaturated Fatty Acids on Pancreatic Cancer Growth

  2008cited by this paper
• Expression of cell cycle inhibitors p21, p27, p14 and p16 in gliomas. Correlation with classic prognostic factors and patients' outcome

  2008cited by this paper
• Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

  2008cited by this paper
• Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials

  2008cited by this paper
• Chronic inflammation and pancreatic cancer.

  2008cited by this paper
• New aspects of regulatory signaling pathways and novel therapies in pancreatic cancer.

  2008cited by this paper
• Cancer Statistics, 2007

  2007cited by this paper
• Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

  2007cited by this paper
• Regulation of COX and LOX by curcumin.

  2007cited by this paper
• Molecular targets of curcumin.

  2007cited by this paper
• Molecular pathogenesis of pancreatic cancer: advances and challenges.

  2007cited by this paper
• Curcumin Augments Gemcitabine Cytotoxic Effect on Pancreatic Adenocarcinoma Cell Lines

  2007cited by this paper
• Antioxidant and anti-inflammatory properties of curcumin.

  2007cited by this paper
• Dietary Lipids and Cancer

  2007cited by this paper
• Role of curcumin in cancer therapy.

  2007cited by this paper
• Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer

  2006cited by this paper
• Multiple molecular targets in cancer chemoprevention by curcumin

  2006cited by this paper
• Effects of omega-3 fatty acids on cancer risk: a systematic review.

  2006cited by this paper
• Consensus report of the International Society of Gastrointestinal Oncology on therapeutic progress in advanced pancreatic cancer

  2006cited by this paper
• Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy.

  2006cited by this paper
• Influence of Different Dietary Fat Intake on Liver Metastasis and Hepatic Lipid Peroxidation in BOP-Induced Pancreatic Cancer in Syrian Hamsters

  2006cited by this paper
• Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.

  2006cited by this paper
• Molecular targets of dietary agents for prevention and therapy of cancer.

  2006cited by this paper
• Effect of Altering Dietary ω-6/ω-3 Fatty Acid Ratios on Prostate Cancer Membrane Composition, Cyclooxygenase-2, and Prostaglandin E2

  2006cited by this paper
• Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases.

  2006cited by this paper
• Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets

  2006cited by this paper
• Melanoma growth is reduced in fat-1 transgenic mice: Impact of omega-6/omega-3 essential fatty acids

  2006cited by this paper
• Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster.

  2006cited by this paper
• Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells.

  2006cited by this paper
• Fish intake, contaminants, and human health: evaluating the risks and the benefits.

  2006cited by this paper
• Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2.

  2006cited by this paper
• Prostate Tumor Growth and Recurrence Can Be Modulated by the ω-6:ω-3 Ratio in Diet: Athymic Mouse Xenograft Model Simulating Radical Prostatectomy

  2006cited by this paper
• Dietary lipids and cancer.

  2006cited by this paper
• Omega-3 fatty acids and cancer risk.

  2006cited by this paper
• Retracted: Notch‐1 down‐regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells

  2006cited by this paper
• Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice

  2005cited by this paper
• The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling.

  2005cited by this paper
• Cyclooxygenases, peroxide tone and the allure of fish oil.

  2005cited by this paper
• Curcumin synergistically potentiates the growth inhibitory and pro-apoptotic effects of celecoxib in pancreatic adenocarcinoma cells.

  2005cited by this paper
• Apoptosis in human pancreatic cancer cells induced by eicosapentaenoic acid.

  2005cited by this paper
• Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids.

  2005cited by this paper
• Docosahexaenoic Acid Induces Apoptosis in the Human PaCa-44 Pancreatic Cancer Cell Line by Active Reduced Glutathione Extrusion and Lipid Peroxidation

  2005cited by this paper
• Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis.

  2005cited by this paper
• Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling.

  2004cited by this paper
• NSAIDs and chemoprevention.

  2004cited by this paper
• Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids

  2004cited by this paper
• Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density.

  2004cited by this paper
• Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms.

  2004cited by this paper
• Nuclear factor‐κB and IκB kinase are constitutively active in human pancreatic cells, and their down‐regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis

  2004cited by this paper
• Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.

  2004cited by this paper
• Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor‐κB signaling

  2004cited by this paper
• (n-3) fatty acids and cancer therapy.

  2004cited by this paper
• Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment.

  2004cited by this paper
• n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway.

  2004cited by this paper
• Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells 1

  2003cited by this paper
• 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions.

  2003cited by this paper
• Molecular prognostic markers in pancreatic cancer.

  2002cited by this paper
• Influence of omega-3 fatty acids on the growth of human colon carcinoma in nude mice.

  2002cited by this paper
• c-Fos expression as endogenous marker of lumbosacral spinal neuron activity in response to vaginocervical-stimulation.

  2002cited by this paper
• Clinical significance of expression of p21 and p53 proteins and proliferating cell nuclear antigen in pancreatic cancer.

  2002cited by this paper
• Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation.

  2001cited by this paper
• Effect of a Fish Oil-Enriched Nutritional Supplement on Metabolic Mediators in Patients With Pancreatic Cancer Cachexia

  2001cited by this paper
• Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells.

  2001cited by this paper
• Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids.

  2001cited by this paper
• Molecular prognostic markers in pancreatic cancer.

  2000cited by this paper
• Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

  1995cited by this paper
• Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon.

  1993cited by this paper

• Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects

  2025cites this paper
• Supramolecular eutectogel based on THDESs as a skin penetrating carrier for effective transdermal delivery of hydrophobic drug curcumin.

  2025cites this paper
• Microemulsion co-delivering curcumin and DHA-rich algal oil alleviates nonalcoholic fatty liver disease

  2024cites this paper
• The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial

  2024cites this paper
• Natural Products for Cancer Prevention and Interception: Preclinical and Clinical Studies and Funding Opportunities

  2024influential citation
• Recent Advances in Curcumin-Based Combination Nanomedicines for Cancer Therapy

  2023cites this paper
• Impact of dietary curcumin administration along with feed-born silver nanoparticle on growth, hemato-biochemical parameters, and digestive enzyme activity of common carp (Cyprinus carpio)

  2023cites this paper
• Identification of curcumin as a novel potential drug for promoting the development of small ovarian follicles for infertility treatment

  2022cites this paper
• Therapeutic effect of curcumin in gastrointestinal cancers: A comprehensive review

  2021cites this paper
• Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics

  2021influential citation
• Interactive Effects of Curcumin and Silver Nanoparticles on Growth, Hemato-Biochemical Parameters, Digestive Enzymes Activity and Histology of Common Carp (Cyprinus Carpio)

  2021cites this paper
• Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers

  2021cites this paper
• Design of new improved curcumin derivatives to multi-targets of cancer and inflammation.

  2020cites this paper
• Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives.

  2020cites this paper
• Quantum dots encapsulated with curcumin inhibit the growth of colon cancer, breast cancer and bacterial cells.

  2020cites this paper
• Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer

  2020cites this paper
• Curcumin - A Novel Therapeutic Agent In The Prevention Of Colorectal Cancer.

  2020cites this paper
• Impact of dietary fat composition and quantity in pancreatic carcinogenesis: Recent advances and controversies.

  2020influential citation
• Synergistic effects of curcumin and its analogs with other bioactive compounds: A comprehensive review.

  2020cites this paper
• Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 cells.

  2019cites this paper
• Encapsulation and release of curcumin using an intact milk fat globule delivery system.

  2019cites this paper
• Nutrition, Immunity, and Cancer

  2019cites this paper
• Therapeutic potential of omega fatty acids in breast cancer. Review

  2019cites this paper
• Eicosapentaenoic Acid and Docosahexaenoic Acid from Fish Oil and Their Role in Cancer Research

  2019cites this paper
• The Interactive Effect of Dietary Curcumin and Silver Nanoparticles on Gut Microbiota of Common Carp (Cyprinus carpio)

  2018cites this paper
• Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature

  2018cites this paper
• Effect of Curcumin-Nanoemulsion Associated with Photodynamic Therapy in Cervical Carcinoma Cell Lines

  2018cites this paper
• The Potential of Curcumin: A Multitargeting Agent in Cancer Cell Chemosensitization

  2018cites this paper
• Emerging role of chemoprotective agents in the dynamic shaping of plasma membrane organization.

  2017cites this paper
• Lack of chemopreventive effects of P2X7R inhibitors against pancreatic cancer

  2017cites this paper
• Impact of Phytochemicals and Dietary Patterns on Epigenome and Cancer

  2017cites this paper
• Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review

  2017cites this paper
• Primary Carcinosarcoma of the Pancreas With CD10-Positive Sarcoma Component

  2017cites this paper
• The effects of Curcuma longa and curcumin on reproductive systems

  2017cites this paper
• Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies

  2017cites this paper
• Targeting Arachidonic Acid Pathway-Associated NF-κB in Pancreatic Cancer

  2017cites this paper
• Knockdown of Delta-5 Desaturase to Elicit Anti-Cancer Effect of Dihomo-γ-Linolenic Acid: Development of an ω-6 Fatty Acid-Based Therapeutic Strategy for Pancreatic Cancer

  2017cites this paper
• Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives.

  2016cites this paper
• Multi-Targeted Agents in Cancer Cell Chemosensitization: What We Learnt from Curcumin Thus Far.

  2016cites this paper
• Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

  2016cites this paper
• Curcumin induces apoptosis in p53-null Hep3B cells through a TAp73/DNp73-dependent pathway

  2016cites this paper
• Pharmacological Intervention through Dietary Nutraceuticals in Gastrointestinal Neoplasia

  2016cites this paper
• Prevention and treatment of cancers by immune modulating nutrients.

  2016cites this paper
• Pharmaceutics, Drug Delivery and Pharmaceutical Technology Thai Silk Fibroin/Gelatin Sponges for the Dual Controlled Release of Curcumin and Docosahexaenoic Acid for Anticancer Treatment

  2016cites this paper
• Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk

  2016cites this paper
• Upregulation of cugbp2 increases response of pancreatic cancer cells to chemotherapy

  2016cites this paper
• The Interactive Effect of Dietary Curcumin and Silver Nanoparticles on Gut Microbiota of Common Carp (Cyprinus carpio)

  2016cites this paper
• Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid

  2016cites this paper
• Curcumin Blocks Naproxen-Induced Gastric Antral Ulcerations through Inhibition of Lipid Peroxidation and Activation of Enzymatic Scavengers in Rats.

  2016cites this paper
• Development and evaluation of curcumin-loaded Pluronic F127 nanoformulation

  2015cites this paper
• Curcumin and Omega-3 Fatty Acids Enhance NK Cell-Induced Apoptosis of Pancreatic Cancer Cells but Curcumin Inhibits Interferon-γ Production: Benefits of Omega-3 with Curcumin against Cancer

  2015cites this paper
• RNA binding protein CUGBP 2 / CELF 2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells

  2015cites this paper
• Combinatorial Approaches Utilizing Nutraceuticals in Cancer Chemoprevention and Therapy

  2015cites this paper
• Curcumin-Loaded Polymeric Nanoparticle: A Promising Route for the Treatment of Cancer

  2015cites this paper
• Low-density lipoprotein-mediated delivery of docosahexaenoic acid selectively kills murine liver cancer cells.

  2014cites this paper
• Active curcumin nanoparticles formed from a volatile microemulsion template.

  2014cites this paper
• In vitro protective effect of Celergen, a bioactive marine compound, on interleukin-6-related invasiveness of pancreatic cancer.

  2014cites this paper
• Improving the Anticancer Activity of Curcumin Using Nanocurcumin Dispersion in Water

  2014cites this paper
• Curcumina: de especiaria à nutracêutico

  2014cites this paper
• The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

  2014cites this paper
• Curcumin a potent cancer preventive agent: Mechanisms of cancer cell killing.

  2014cites this paper
• Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice

  2013cites this paper
• Evaluating dietary compounds in pancreatic cancer modeling systems.

  2013cites this paper
• Turmeric and Pancreatic Cancer- A Review

  2013cites this paper
• Types of fish consumed and fish preparation methods in relation to pancreatic cancer incidence: the VITAL Cohort Study.

  2013cites this paper
• The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer

  2013cites this paper
• Upregulation of extrinsic apoptotic pathway in curcumin‐mediated antiproliferative effect on human pancreatic carcinogenesis

  2013cites this paper
• Frontiers in Research: Herbal Bioactive Molecules: The Hidden Jewels for Drug Development Discovery of curcumin, a component of golden spice, and its miraculous biological activities

  2012cites this paper
• Molecular pathogenesis of gastric ulcers and strategies for prevention

  2012cites this paper
• Folate-conjugated rapamycin slows progression of polycystic kidney disease.

  2012cites this paper
• Endogenous n-3 Polyunsaturated Fatty Acids Delay Progression of Pancreatic Ductal Adenocarcinoma

  2012cites this paper
• Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice.

  2012cites this paper
• Therapeutic potential of curcumin in gastrointestinal diseases.

  2011cites this paper
• The Beneficial Effects of Nutritional Compounds on Breast Cancer Metastasis

  2011cites this paper
• A high omega-3 fatty acid diet mitigates murine pancreatic precancer development.

  2011cites this paper
• Plant Science and Human Nutrition: Challenges in Assessing Health-Promoting Properties of Phytochemicals[C][OA]

  2011cites this paper
• Gastric Ulcer's Diseases Pathogenesis, Complications And Strategies For Prevention

  2011cites this paper
• Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects.

  2011cites this paper
• Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.

  2011cites this paper
• Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system.

  2011cites this paper
• A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone

  2011cites this paper
• Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy

  2011cites this paper
• RNA Binding Protein CUGBP2/CELF2 Mediates Curcumin-Induced Mitotic Catastrophe of Pancreatic Cancer Cells

  2011cites this paper
• An Overview of Anticancer Herbal Medicines

  2011cites this paper
• Omega‐3 fatty acid supplementation delays the progression of neuroblastoma in vivo

  2011cites this paper
• Omega-3-Polyunsaturated Fatty Acids Suppress Pancreatic Cancer Cell Growth in vitro and in vivo via Downregulation of Wnt/Beta-Catenin Signaling

  2011cites this paper
• ω-3 PUFAs and Other Cancers

  2010cites this paper
• Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications.

  2010cites this paper
• Chemoprevention strategies for pancreatic cancer

  2010cites this paper
• Role of nitric oxide in the treatment of non‐alcoholic fatty liver by omega‐3 fatty acids

  2010cites this paper
• Curcumin―The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention and Treatment

  2010cites this paper
• Effect of a novel Omegacoeur®/Doluperine® nutritional combination on human embryonic kidney cell viability

  2010cites this paper
• Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?

  2010cites this paper
• Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF.

  2010cites this paper
• Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies

  2010cites this paper
• Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

  2009cites this paper
• Anti-ulcer activity of curcumin on experimental gastric ulcer in rats and its effect on oxidative stress/antioxidant, IL-6 and enzyme activities.

  2009cites this paper
• Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice

  2009cites this paper
• Lipid mediators in the prevention and therapy of neuroblastoma

  2009cites this paper