NFIL3/E4BP4 controls type 2 T helper cell cytokine expression

No abstract is available for this paper.

• Publication year

  2011

• Venue

  EMBO Journal

• Publication date

  2011-05-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2011.111PMID 21499227PMCID PMC3098483
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling1

  2009cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• The IL-4 receptor: signaling mechanisms and biologic functions.

  1999cited by this paper
• The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation.

  1998cited by this paper
• The Chimeric E2A-HLF Transcription Factor Abrogates p53-Induced Apoptosis in Myeloid Leukemia Cells

  1998cited by this paper
• Interleukin-13: central mediator of allergic asthma.

  1998cited by this paper
• Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation.

  1998cited by this paper
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  1997cited by this paper
• Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter

  1995cited by this paper
• Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development.

  1995cited by this paper
• Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene.

  1995cited by this paper
• Transcriptional repression by a novel member of the bZIP family of transcription factors

  1992cited by this paper

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