Quantitative Assessment of Diffusion-Weighted MR Imaging in Patients with Primary Rectal Cancer: Correlation with FDG-PET/CT

PurposeThe aim of the study was to assess correlations between parameters on diffusion-weighted imaging and 2-deoxy-2-[18F]fluoro-d-glucose–positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer.ProceduresThirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADCmean (average ADC), ADCmin (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUVmax (maximum SUV), SUVmean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold.ResultsSignificant negative correlations were found between ADCmin and SUVmax (r = −0.450, p = 0.009), and between ADCmean and SUVmean (r = −0.402, p = 0.020). A significant positive correlation was found between TDI and TLG (r = 0.634, p < 0.001).ConclusionThe significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma.

• Publication year

  2010

• Venue

  Molecular Imaging and Biology

• Publication date

  2010-09-25

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s11307-010-0433-7PMID 20872077PMCID 3179585
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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