Piroxicam is an ineffective inhibitor of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Cancer Research

• Publication date

  2002-08-01

• Fields of study

  Medicine

• Identifiers
  PMID 12154043
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Expression of cyclooxygenase-2 in human transitional cell carcinoma of the urinary bladder.

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• Incidence and effects of Ha‐ras codon 12 G→A transition mutations in preneoplastic lesions induced by N‐nitrosomethylbenzylamine in the rat esophagus

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• Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.

  2001cited by this paper
• Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline 1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor,nimesulide

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• Cyclooxygenase-2 is overexpressed in human cervical cancer.

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• Lipoxygenase modulation to reverse carcinogenesis.

  2001influential reference
• Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos.

  2000cited by this paper
• Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure.

  2000cited by this paper
• 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.

  2000cited by this paper
• Aspirin induction of apoptosis in esophageal cancer: a potential for chemoprevention.

  2000influential reference
• Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

  1999cited by this paper
• Cyclooxygenase-2 expression in human esophageal carcinoma.

  1999cited by this paper
• Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers.

  1999cited by this paper
• Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.

  1999cited by this paper
• Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Estimates of the worldwide incidence of 25 major cancers in 1990

  1999cited by this paper
• Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer.

  1998cited by this paper
• Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas.

  1998cited by this paper
• Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.

  1998cited by this paper
• Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer.

  1998cited by this paper
• Cyclooxygenase in biology and disease

  1998cited by this paper
• Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas.

  1998cited by this paper
• Chemopreventive efficacy of piroxicam administered alone or in combination with lycopene and β-carotene on the development of rat urinary bladder carcinoma after N-Butyl-N-(4-Hydroxybutyl) nitrosamine treatment

  1997cited by this paper
• Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.

  1997cited by this paper
• Cyclooxygenase-2 gene expression in human breast cancer.

  1997cited by this paper
• Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs*

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• Chemopreventive Efficacy of Piroxicam Administered Alone or in Combination with Lycopene and β‐Carotene on the Development of Rat Urinary Bladder Carcinoma after A N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine Treatment

  1997cited by this paper
• Expression of cyclooxygenase-2 in human gastric carcinoma.

  1997cited by this paper
• Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion.

  1997cited by this paper
• A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells.

  1997cited by this paper
• Piroxicam-induced regression of azoxymethane-induced aberrant crypt foci and prevention of colon cancer in rats.

  1996cited by this paper
• Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors.

  1996cited by this paper
• Prostaglandin synthase 2.

  1996cited by this paper
• Elevated cyclooxygenase-2 levels in Min mouse adenomas.

  1996cited by this paper
• Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats.

  1996cited by this paper
• Alterations in transforming growth factor‐α and epidermal growth factor receptor expression during rat esophageal tumorigenesis

  1996cited by this paper
• Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam.

  1996cited by this paper
• Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

  1995cited by this paper
• Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

  1995cited by this paper
• Effects of dietary phenethyl isothiocyanate, ellagic acid, sulindac and calcium on the induction and progression of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats.

  1995cited by this paper
• Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

  1995cited by this paper
• Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

  1995cited by this paper
• Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis

  1995cited by this paper
• Aspirin and reduced risk of esophageal carcinoma

  1995cited by this paper
• Evaluation of dose and treatment duration on the esophageal tumorigenicity of N-nitrosomethylbenzylamine in rats.

  1995influential reference
• Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas.

  1994cited by this paper
• Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
• Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats.

  1993cited by this paper
• Aspirin use and risk of fatal cancer.

  1993cited by this paper
• Inhibitory effect of the non-steroidal anti-inflammatory drugs, indomethacin and piroxicam on 2-acetylaminofluorene-induced hepatocarcinogenesis in male ACI/N rats.

  1993cited by this paper
• The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat.

  1992cited by this paper
• Aspirin and the potential role of prostaglandins in colon cancer.

  1992cited by this paper
• Effects of NSAIDs on NNK-induced pulmonary and gastric tumorigenesis in A/J mice.

  1992cited by this paper
• Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds.

  1992cited by this paper
• Genotoxicity of heated cooking oil vapors.

  1992cited by this paper
• Ha-ras induction of the invasive phenotype results in up-regulation of epidermal growth factor receptors and altered responsiveness to epidermal growth factor in human papillary transitional cell carcinoma cells.

  1991cited by this paper
• Altered regulation of TGF-beta 1 and TGF-alpha in primary keratinocytes and papillomas expressing v-Ha-ras.

  1991cited by this paper
• An endoplasmic reticulum-specific cyclophilin

  1991cited by this paper
• Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha-difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination.

  1991cited by this paper
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  1991cited by this paper
• Mutational activation of the cellular Harvey ras oncogene in rat esophageal papillomas induced by methylbenzylnitrosamine.

  1990cited by this paper
• Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet.

  1990cited by this paper
• A comparison of the effects of the prostaglandin synthesis inhibitors indomethacin and carprofen on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats fed different amounts of essential fatty acid.

  1989cited by this paper
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  1987cited by this paper
• Further studies on the therapeutic effect of indomethacin on esophageal tumors

  1986cited by this paper
• Antitumoral activity of indomethacin on experimental esophageal tumors.

  1984cited by this paper
• Nonsteroidal anti-inflammatory drugs stimulate 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes.

  1984cited by this paper
• Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

  1971cited by this paper
• Chemoprevention of Colon Carcinogenesis by Sulindac , a Nonsteroidal Anti-inflammatory Agent 1

  year unknowncited by this paper

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