Cell-lineage specificity and role of AP-1 in the prostate fibroblast androgen receptor cistrome.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2017-01-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mce.2016.09.010PMID 27634452
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma

  2016cited by this paper
• AP-1 Transcription Factors c-FOS and c-JUN Mediate GnRH-Induced Cadherin-11 Expression and Trophoblast Cell Invasion.

  2015cited by this paper
• Tissue-based map of the human proteome

  2015cited by this paper
• Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes

  2015cited by this paper
• Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation

  2015cited by this paper
• Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway

  2015cited by this paper
• Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies

  2015influential reference
• Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome

  2015influential reference
• Androgens and mammalian male reproductive tract development.

  2015cited by this paper
• Tissue‐specific pioneer factors associate with androgen receptor cistromes and transcription programs

  2014cited by this paper
• Hic-5 influences genomic and non-genomic actions of the androgen receptor in prostate myofibroblasts.

  2014influential reference
• Cooperativity and Equilibrium with FOXA1 Define the Androgen Receptor Transcriptional Program

  2014influential reference
• Epithelial plasticity in prostate cancer: principles and clinical perspectives.

  2014cited by this paper
• Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo

  2014cited by this paper
• Age-associated reduction of cellular spreading/mechanical force up-regulates matrix metalloproteinase-1 expression and collagen fibril fragmentation via c-Jun/AP-1 in human dermal fibroblasts

  2014cited by this paper
• Androgen receptor as a regulator of ZEB2 expression and its implications in epithelial-to-mesenchymal transition in prostate cancer.

  2014cited by this paper
• Extracellular Signal-Regulated Kinase Signaling Regulates the Opposing Roles of JUN Family Transcription Factors at ETS/AP-1 Sites and in Cell Migration

  2014cited by this paper
• Silibinin inhibits prostate cancer cells‐ and RANKL‐induced osteoclastogenesis by targeting NFATc1, NF‐κB, and AP‐1 activation in RAW264.7 cells

  2014cited by this paper
• Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex is mediated by a c-Jun/AP-1-modulated enhancer

  2014cited by this paper
• Oxidant Exposure Induces Cysteine-Rich Protein 61 (CCN1) via c-Jun/AP-1 to Reduce Collagen Expression in Human Dermal Fibroblasts

  2014cited by this paper
• The role of transcription factors in prostate cancer and potential for future RNA interference therapy

  2014cited by this paper
• Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer.

  2014cited by this paper
• miRNA and mRNA cancer signatures determined by analysis of expression levels in large cohorts of patients

  2013influential reference
• Cell-type and transcription factor specific enrichment of transcriptional cofactor motifs in ENCODE ChIP-seq data

  2013cited by this paper
• Cell mates: paracrine and stromal targets for prostate cancer therapy

  2013cited by this paper
• The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man.

  2013influential reference
• Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype

  2013cited by this paper
• AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer

  2013cited by this paper
• Target analysis by integration of transcriptome and ChIP-seq data with BETA

  2013cited by this paper
• Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications

  2013cited by this paper
• Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study.

  2012influential reference
• EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

  2012influential reference
• Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

  2012cited by this paper
• c-Jun/AP-1 is required for CCK-induced pancreatic acinar cell dedifferentiation and DNA synthesis in vitro.

  2012cited by this paper
• Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions

  2012influential reference
• Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF

  2012cited by this paper
• Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis.

  2012cited by this paper
• Subdomain structure of the co-chaperone SGTA and activity of its androgen receptor client.

  2012cited by this paper
• Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate

  2011influential reference
• mRNA expression signature of Gleason grade predicts lethal prostate cancer.

  2011cited by this paper
• Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

  2011influential reference
• Effects of Androgen Receptor and Androgen on Gene Expression in Prostate Stromal Fibroblasts and Paracrine Signaling to Prostate Cancer Cells

  2011influential reference
• Cistrome: an integrative platform for transcriptional regulation studies

  2011influential reference
• Lupeol, a Novel Androgen Receptor Inhibitor: Implications in Prostate Cancer Therapy

  2011cited by this paper
• Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

  2011cited by this paper
• GeneProf: analysis of high-throughput sequencing experiments

  2011cited by this paper
• Towards a knowledge-based Human Protein Atlas

  2010cited by this paper
• An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.

  2010cited by this paper
• Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

  2010cited by this paper
• A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.

  2009cited by this paper
• Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification

  2009cited by this paper
• FoxA1 Binding Directs Chromatin Structure and the Functional Response of a Glucocorticoid Receptor-Regulated Promoter

  2009cited by this paper
• A novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin.

  2009influential reference
• A luminal epithelial stem cell that is a cell of origin for prostate cancer

  2009influential reference
• Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.

  2009cited by this paper
• Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients

  2009influential reference
• FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

  2008cited by this paper
• Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer.

  2008cited by this paper
• Chop it, ChIP it, check it: the current status of chromatin immunoprecipitation.

  2008cited by this paper
• BioVenn – a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams

  2008cited by this paper
• Decrease in stromal androgen receptor associates with androgen-independent disease and promotes prostate cancer cell proliferation and invasion

  2008influential reference
• Model-based Analysis of ChIP-Seq (MACS)

  2008cited by this paper
• Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma.

  2007cited by this paper
• Androgen receptor coregulators and their involvement in the development and progression of prostate cancer

  2007cited by this paper
• Contemporary trends in low risk prostate cancer: risk assessment and treatment.

  2007cited by this paper
• Characterization of the androgen receptor in a benign prostate tissue-derived human prostate epithelial cell line: RC-165N/human telomerase reverse transcriptase

  2007cited by this paper
• Stromal-epithelial cell interactions and androgen receptor-coregulator recruitment is altered in the tissue microenvironment of prostate cancer.

  2007cited by this paper
• JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update

  2007influential reference
• Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element.

  2006cited by this paper
• c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation

  2006cited by this paper
• Extracellular signal-regulated kinases and AP-1 mediate the up-regulation of vascular endothelial growth factor by PDGF in human vascular smooth muscle cells.

  2006cited by this paper
• Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer.

  2005cited by this paper
• Induction of AP‐1 activity by androgen activation of the androgen receptor in LNCaP human prostate carcinoma cells

  2005cited by this paper
• Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.

  2005influential reference
• A Human Protein Atlas for Normal and Cancer Tissues Based on Antibody Proteomics*

  2005cited by this paper
• Isolation and characterization of an immortalized mouse urogenital sinus mesenchyme cell line

  2005cited by this paper
• Androgen receptor levels in prostate cancer epithelial and peritumoral stromal cells identify non‐organ confined disease

  2005influential reference
• A telomerase-immortalized primary human prostate cancer clonal cell line with neoplastic phenotypes.

  2004cited by this paper
• Contribution of the Androgen Receptor to Prostate Cancer Predisposition and Progression

  2004cited by this paper
• Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype.

  2003cited by this paper
• JunD protects against chronic kidney disease by regulating paracrine mitogens.

  2003cited by this paper
• The role of hepatocyte nuclear factor-3 alpha (Forkhead Box A1) and androgen receptor in transcriptional regulation of prostatic genes.

  2003cited by this paper
• Transcription factor activation in response to cutaneous injury: Role of AP‐1 in reepithelialization

  2002cited by this paper
• Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4.

  2002cited by this paper
• Altered expression of androgen receptor in the malignant epithelium and adjacent stroma is associated with early relapse in prostate cancer.

  2001influential reference
• c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin.

  2000cited by this paper
• Transcriptional interferences between normal or mutant androgen receptors and the activator protein 1--dissection of the androgen receptor functional domains.

  1999cited by this paper
• Malignant transformation of human prostatic epithelium is associated with the loss of androgen receptor immunoreactivity in the surrounding stroma.

  1999influential reference
• Binding of the winged‐helix transcription factor HNF3 to a linker histone site on the nucleosome

  1998cited by this paper
• Androgenic Induction of Prostate-specific Antigen Gene Is Repressed by Protein-Protein Interaction between the Androgen Receptor and AP-1/c-Jun in the Human Prostate Cancer Cell Line LNCaP*

  1997influential reference
• Derivation of androgen‐independent human LNCaP prostatic cancer cell sublines: Role of bone stromal cells

  1994cited by this paper
• Genetic predisposition and mesenchymal‐epithelial interactions in ras + myc—induced carcinogenesis in reconstituted mouse prostate

  1993cited by this paper

• Prostate Cancer-Associated Fibroblasts: A Review on CAF Functions, Heterogeneity, Resistance Mechanisms, and Future in a Chip

  2026cites this paper
• Androgen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth

  2023cites this paper
• Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

  2023cites this paper
• Cellular specificity of androgen receptor, coregulators, and pioneer factors in prostate cancer

  2022cites this paper
• Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer

  2022cites this paper
• Prostate Cancer Epigenetic Plasticity and Enhancer Heterogeneity: Molecular Causes, Consequences and Clinical Implications.

  2022cites this paper
• Enzalutamide, a prostate cancer therapeutic, downregulates TMPRSS2 in lung and reduces cellular entry of SARS-CoV-2

  2021cites this paper
• Elevated expression of the colony-stimulating factor 1 (CSF1) induces prostatic intraepithelial neoplasia dependent of epithelial-Gp130.

  2021cites this paper
• The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells

  2021cites this paper
• Characteristics and possible mechanisms of 46, XY differences in sex development caused by novel compound variants in NR5A1 and MAP3K1

  2021cites this paper
• Androgen Signaling in the Tumor Microenvironment.

  2021cites this paper
• Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

  2020cites this paper
• Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals conservation of bone microenvironment signatures

  2020cites this paper
• Novel compound variants of the AR and MAP3K1 genes are related to the clinical heterogeneity of androgen insensitivity syndrome

  2020cites this paper
• ARe we there yet? Understanding androgen receptor signaling in breast cancer

  2020cites this paper
• TMPRSS2, required for SARS-CoV-2 entry, is downregulated in lung cells by enzalutamide, a prostate cancer therapeutic

  2020cites this paper
• Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancers.

  2019cites this paper
• The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review

  2019cites this paper
• Neural Transcription Factors in Disease Progression.

  2019cites this paper
• Factors that influence the androgen receptor cistrome in benign and malignant prostate cells

  2019cites this paper
• Tissue-specific progesterone receptor-chromatin binding and the regulation of progesterone-dependent gene expression

  2019cites this paper
• Regulation of masculinization: androgen signalling for external genitalia development

  2018cites this paper
• Enduring epigenetic landmarks define the cancer microenvironment

  2018cites this paper
• Loss of androgen receptor signaling in prostate cancer‐associated fibroblasts (CAFs) promotes CCL2‐ and CXCL8‐mediated cancer cell migration

  2018cites this paper
• Myofibroblast androgen receptor expression determines cell survival in co-cultures of myofibroblasts and prostate cancer cells in vitro

  2018cites this paper
• Androgen receptor moonlighting in the prostate cancer microenvironment.

  2018cites this paper
• Stromal Androgen Receptor in Prostate Cancer Development and Progression

  2017cites this paper
• Genome-wide analysis of AR binding and comparison with transcript expression in primary human fetal prostate fibroblasts and cancer associated fibroblasts.

  2017cites this paper