From silk spinning in insects and spiders to advanced silk fibroin drug delivery systems.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  European journal of pharmaceutics and biopharmaceutics

• Publication date

  2015-11-01

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.1016/j.ejpb.2015.03.016PMID 25801494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pulmonary Insulin-like Growth Factor I Delivery from Trehalose and Silk-Fibroin Microparticles

  2015cited by this paper
• Deciphering the mechanism of protein interaction with silk fibroin for drug delivery systems.

  2014cited by this paper
• Regenerated silk fibroin films with controllable nanostructure size and secondary structure for drug delivery.

  2014cited by this paper
• In vivo biodegradation of porous silk fibroin films implanted beneath the skin and muscle of the rat

  2014cited by this paper
• Silk-based biomaterials for sustained drug delivery.

  2014cited by this paper
• Inkjet printing of silk nest arrays for cell hosting.

  2014cited by this paper
• Controlled assembly: a prerequisite for the use of recombinant spider silk in regenerative medicine?

  2014cited by this paper
• Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation

  2014cited by this paper
• Cytocompatibility of a silk fibroin tubular scaffold.

  2014cited by this paper
• Remodeling of tissue-engineered bone structures in vivo.

  2013cited by this paper
• Facile preparation of paclitaxel loaded silk fibroin nanoparticles for enhanced antitumor efficacy by locoregional drug delivery.

  2013cited by this paper
• pH‐Dependent Anticancer Drug Release from Silk Nanoparticles

  2013cited by this paper
• Drug loading and release on tumor cells using silk fibroin–albumin nanoparticles as carriers

  2013cited by this paper
• Biocompatibility and osteoconduction of macroporous silk fibroin implants in cortical defects in sheep.

  2013cited by this paper
• Silk fibroin-based scaffolds for bone regeneration.

  2013cited by this paper
• Morphology and composition of the spider major ampullate gland and dragline silk.

  2013cited by this paper
• Self‐Assembling Doxorubicin Silk Hydrogels for the Focal Treatment of Primary Breast Cancer

  2013cited by this paper
• Silk fibroin biomaterials for tissue regenerations.

  2013cited by this paper
• Silk self-assembly mechanisms and control from thermodynamics to kinetics.

  2012cited by this paper
• Silk constructs for delivery of musculoskeletal therapeutics.

  2012cited by this paper
• Preparation and in vivo degradation of controlled biodegradability of electrospun silk fibroin nanofiber mats.

  2012cited by this paper
• The role of terminal domains during storage and assembly of spider silk proteins

  2012cited by this paper
• Bone targeting for the treatment of osteoporosis.

  2012cited by this paper
• Physical and chemical aspects of stabilization of compounds in silk

  2012cited by this paper
• Implantable, multifunctional, bioresorbable optics

  2012cited by this paper
• Silk Fibroin in Tissue Engineering

  2012cited by this paper
• N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease.

  2012cited by this paper
• Electrospun matrices for localized drug delivery: current technologies and selected biomedical applications.

  2012cited by this paper
• Doxorubicin-loaded silk films: drug-silk interactions and in vivo performance in human orthotopic breast cancer.

  2012cited by this paper
• pH-dependent dimerization and salt-dependent stabilization of the N-terminal domain of spider dragline silk--implications for fiber formation.

  2011cited by this paper
• Silk fibroin as a vehicle for drug delivery applications.

  2011cited by this paper
• Mechanisms of controlled release from silk fibroin films.

  2011cited by this paper
• Der molekulare Mechanismus der Bildung von Spinnenseide

  2010cited by this paper
• A conserved spider silk domain acts as a molecular switch that controls fibre assembly

  2010cited by this paper
• The role of salt and shear on the storage and assembly of spider silk proteins.

  2010cited by this paper
• Silk fibroin nanoparticles for cellular uptake and control release.

  2010cited by this paper
• Molecular and nanostructural mechanisms of deformation, strength and toughness of spider silk fibrils.

  2010cited by this paper
• Cytocompatibility of regenerated silk fibroin film: a medical biomaterial applicable to wound healing

  2010cited by this paper
• Silk fibroin-derived nanoparticles for biomedical applications.

  2010cited by this paper
• The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration.

  2010cited by this paper
• Silk-based delivery systems of bioactive molecules.

  2010cited by this paper
• Silk Fibroin Microparticles as Carriers for Delivery of Human Recombinant Bone Morphogenetic Protein-2: In Vitro and In Vivo Bioactivity

  2010cited by this paper
• Controlling silk fibroin particle features for drug delivery.

  2010cited by this paper
• New Opportunities for an Ancient Material

  2010cited by this paper
• Electrospun scaffolds from silk fibroin and their cellular compatibility.

  2009cited by this paper
• Silk Fibers Extruded Artificially from Aqueous Solutions of Regenerated Bombyx mori Silk Fibroin are Tougher than their Natural Counterparts

  2009cited by this paper
• Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering.

  2009cited by this paper
• Microporous silk fibroin scaffolds embedding PLGA microparticles for controlled growth factor delivery in tissue engineering.

  2009cited by this paper
• Optimization strategies for electrospun silk fibroin tissue engineering scaffolds.

  2009cited by this paper
• Single molecule force measurements delineate salt, pH and surface effects on biopolymer adhesion

  2009cited by this paper
• Biodegradation of Silk Biomaterials

  2009cited by this paper
• Silks as ancient models for modern polymers

  2009cited by this paper
• Biopolymer-Based Growth Factor Delivery for Tissue Repair: From Natural Concepts to Engineered Systems

  2009cited by this paper
• Silk fibroin spheres as a platform for controlled drug delivery.

  2008cited by this paper
• Silk fibroin solution properties related to assembly and structure.

  2008cited by this paper
• Hydrophobic and Hofmeister effects on the adhesion of spider silk proteins onto solid substrates: an AFM-based single-molecule study.

  2008cited by this paper
• Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells.

  2008cited by this paper
• Assembly mechanism of recombinant spider silk proteins

  2008cited by this paper
• Control of in vitro tissue-engineered bone-like structures using human mesenchymal stem cells and porous silk scaffolds.

  2007cited by this paper
• Silk microspheres for encapsulation and controlled release.

  2007cited by this paper
• Biocompatibility evaluation of silk fibroin with peripheral nerve tissues and cells in vitro.

  2007cited by this paper
• Silk fibroin matrices for the controlled release of nerve growth factor (NGF).

  2007cited by this paper
• Silk as a Biomaterial.

  2007cited by this paper
• Natural and unnatural silks

  2007cited by this paper
• Some observations on the structure and function of the spinning apparatus in the silkworm Bombyx mori.

  2007cited by this paper
• Cartilage-like Tissue Engineering Using Silk Scaffolds and Mesenchymal Stem Cells

  2006cited by this paper
• Regenerated silk fibroin nanofibers: water vapor-induced structural changes and their effects on the behavior of normal human cells.

  2006cited by this paper
• Silk fibroin as an organic polymer for controlled drug delivery.

  2006cited by this paper
• Evidence from 13C solid‐state NMR spectroscopy for a lamella structure in an alanine–glycine copolypeptide: A model for the crystalline domain of Bombyx mori silk fiber

  2005cited by this paper
• Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin.

  2005cited by this paper
• The inflammatory responses to silk films in vitro and in vivo.

  2005cited by this paper
• Silk implants for the healing of critical size bone defects.

  2005cited by this paper
• Water‐Stable Silk Films with Reduced β‐Sheet Content

  2005cited by this paper
• Effect of metallic ions on silk formation in the Mulberry silkworm, Bombyx mori.

  2005cited by this paper
• Spider silk protein refolding is controlled by changing pH.

  2004cited by this paper
• Study of protein conformation and orientation in silkworm and spider silk fibers using Raman microspectroscopy.

  2004cited by this paper
• Transition to a beta-sheet-rich structure in spidroin in vitro: the effects of pH and cations.

  2004cited by this paper
• pH induced changes in the rheology of silk fibroin solution from the middle division of Bombyx mori silkworm.

  2004cited by this paper
• Mechanism of silk processing in insects and spiders

  2003cited by this paper
• Silk-based biomaterials.

  2003cited by this paper
• Enzymatic degradation behavior of porous silk fibroin sheets.

  2003cited by this paper
• Biological liquid crystal elastomers.

  2002cited by this paper
• Rheology and dynamic light scattering of silk fibroin solution extracted from the middle division of Bombyx mori silkworm.

  2002cited by this paper
• Liquid crystalline spinning of spider silk

  2001cited by this paper
• Changes in element composition along the spinning duct in a Nephila spider

  2001cited by this paper
• Conformational transitions in model silk peptides.

  2000cited by this paper
• Mechanical properties of single‐brin silkworm silk

  2000cited by this paper
• Beta transition and stress-induced phase separation in the spinning of spider dragline silk.

  2000cited by this paper
• Strength and structure of spiders' silks.

  2000cited by this paper
• Liquid crystals and flow elongation in a spider's silk production line

  1999cited by this paper
• Structure and function of the silk production pathway in the spider Nephila edulis.

  1999cited by this paper
• Immobilization of peroxidase with a Bombyx mori silk fibroin membrane and its application to biophotosensors

  1989cited by this paper
• The structure and properties of spider silk

  1986cited by this paper
• Spider silk as rubber

  1984cited by this paper
• Dimensions, Birefringences, and Force-Elongation Behavior of Major and Minor Ampullate Silk Fibers from Orb-Web-Spinning Spiders—The Effects of Wetting on these Properties

  1977cited by this paper
• Synthesis of Silk, Mechanism and Location

  1969cited by this paper

• Cryo-EM structures of artificial spider silk nanofibrils reveal insights into β sheet crystallization

  2025cites this paper
• Trends in protein derived materials for wound care applications.

  2024cites this paper
• Silk fibroin microgels as a platform for cell microencapsulation

  2022cites this paper
• Anti-inflammatory potential of baicalein combined with silk fibroin protein in a zebrafish model (Danio rerio)

  2022cites this paper
• A review on advances in the applications of spider silk in biomedical issues.

  2021cites this paper
• Sericin and fibroin nanoparticles—natural product for cancer therapy: a comprehensive review

  2020cites this paper
• Silk fibroin-based nanotherapeutics: application in the treatment of colonic diseases.

  2019cites this paper
• Experimental Methods for Characterizing the Secondary Structure and Thermal Properties of Silk Proteins.

  2018cites this paper
• Reverse-engineered silk hydrogels for cell and drug delivery.

  2018cites this paper
• Degradation Behavior of Silk Nanoparticles-Enzyme Responsiveness.

  2018cites this paper
• Biomimetic synthesis of sericin and silica hybrid colloidosomes for stimuli-responsive anti-cancer drug delivery systems.

  2017cites this paper
• Investigate the Effect of Thawing Process on the Self-Assembly of Silk Protein for Tissue Applications

  2017cites this paper
• Sericin Promotes Fibroin Silk I Stabilization Across a Phase-Separation.

  2017cites this paper
• Recombinant spider silk protein particles for a modern vaccination approach

  2017cites this paper
• Molecular and macro-scale analysis of enzyme-crosslinked silk hydrogels for rational biomaterial design.

  2017cites this paper
• Silk nanoparticles—an emerging anticancer nanomedicine

  2017cites this paper
• Inner ear delivery of dexamethasone using injectable silk-polyethylene glycol (PEG) hydrogel.

  2016cites this paper
• PEGylated Silk Nanoparticles for Anticancer Drug Delivery.

  2015cites this paper