Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster.

No abstract is available for this paper.

• Publication year

  1990

• Venue

  EMBO Journal

• Publication date

  1990-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/j.1460-2075.1990.tb07890.xPMID 1702382PMCID PMC552231
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic analysis of the Shaker gene complex of Drosophila melanogaster.

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• A voltage-clamp analysis of gene-dosage effects of the Shaker locus on larval muscle potassium currents in Drosophila

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• Alterations in activation gating of single Shaker A-type potassium channels by the Sh5 mutation

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• Gene regulation. Action of leucine zippers.

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• The interference of truncated with normal potassium channel subunits leads to abnormal behaviour in transgenic Drosophila melanogaster.

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• Structural parts involved in activation and inactivation of the sodium channel

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• A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning

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• The organization of 3' splice-site sequences in mammalian introns.

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• Molecular basis of functional diversity of voltage‐gated potassium channels in mammalian brain.

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• Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor.

  1989cited by this paper
• A family of putative potassium channel genes in Drosophila.

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• Potassium channels from NG108‐15 neuroblastoma‐glioma hybrid cells

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• The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.

  1988cited by this paper
• Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.

  1988cited by this paper
• Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

  1988cited by this paper
• Multiple potassium-channel components are produced by alternative splicing at the shaker locus in Drosophila

  1988cited by this paper
• A-type potassium channels expressed from Shaker locus cDNA.

  1988cited by this paper
• Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes.

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• Potassium channels expressed from rat brain cDNA have delayed rectifier properties

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• Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity.

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• Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel.

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• Action potentials in normal and Shaker mutant Drosophila.

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• Abnormal action potentials associated with the Shaker complex locus of Drosophila.

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• DNA sequencing with chain-terminating inhibitors.

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