APE1 and XRCC1 Protein Expression Levels Predict Cancer-Specific Survival Following Radical Radiotherapy in Bladder Cancer

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Clinical Cancer Research

• Publication date

  2005-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-05-0045PMID 16144922
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Systemic chemotherapy for patients with bladder cancer--current controversies and future directions.

  2004cited by this paper
• Selective bladder preservation for muscle-invasive transitional cell carcinoma of the urinary bladder

  2004cited by this paper
• p53 and p21 expression levels predict organ preservation and survival in invasive bladder carcinoma treated with a combined‐modality approach

  2004cited by this paper
• Prognostic significance of a grading system considering tumor heterogeneity in muscle-invasive urothelial carcinoma of the urinary bladder

  2004cited by this paper
• Expression of Ku80 in Cervical Cancer Correlates With Response to Radiotherapy and Survival

  2003cited by this paper
• Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression.

  2003cited by this paper
• Radical radiotherapy and salvage cystectomy as the primary management of transitional cell carcinoma of the bladder. Results following the introduction of a CT planning technique.

  2002cited by this paper
• Expression profiling of microdissected pancreatic adenocarcinomas

  2002cited by this paper
• Selective bladder preservation by combined modality protocol treatment: long-term outcomes of 190 patients with invasive bladder cancer.

  2002cited by this paper
• Combined-modality treatment and selective organ preservation in invasive bladder cancer: long-term results.

  2002cited by this paper
• Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.

  2001cited by this paper
• Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity.

  2001cited by this paper
• Genomic instability in cancer.

  2001cited by this paper
• Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients.

  2001cited by this paper
• XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions

  2001cited by this paper
• Combined p21WAF1/CIP1 and p53 overexpression predict improved survival in muscle-invasive bladder cancer treated by radical radiotherapy.

  2001cited by this paper
• Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli

  2001cited by this paper
• Going APE over ref-1.

  2000cited by this paper
• Expression of Ku70 correlates with survival in carcinoma of the cervix

  2000cited by this paper
• Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers.

  1998cited by this paper
• Radical cystectomy for carcinoma of the bladder: critical evaluation of the results in 1,026 cases.

  1997cited by this paper
• Prognostic factors in patients with bladder carcinoma treated with definitive irradiation

  1990cited by this paper
• DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability.

  1988cited by this paper
• Radiation and hydrogen peroxide induced free radical damage to DNA.

  1987cited by this paper
• Prognostic indices for bladder cancer: an analysis of patients with transitional cell carcinoma of the bladder primarily treated by radical megavoltage X-ray therapy.

  1986cited by this paper
• DNA double-strand breaks generated by the repair of X-ray damage in Chinese hamster cells.

  1982cited by this paper
• DNA strand breaks, repair, and survival in x-irradiated mammalian cells.

  1976cited by this paper
• Enzymatic induction of DNA double-strand breaks in gamma-irradiated Escherichia coli K-12.

  1975cited by this paper

• Targeting the Enhanced Sensitivity of Radiotherapy in Cancer: Mechanisms, Applications, and Challenges

  2025cites this paper
• APE1 promotes lung adenocarcinoma through G4-mediated transcriptional reprogramming of urea cycle metabolism

  2025cites this paper
• Molecular mechanisms of sensitivity and resistance to radiotherapy

  2024cites this paper
• Imaging-guided companion diagnostics in radiotherapy by monitoring APE1 activity with afterglow and MRI imaging

  2024cites this paper
• Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer

  2024cites this paper
• Targeting APE1: Advancements in the Diagnosis and Treatment of Tumors.

  2024cites this paper
• Bladder Cancer Treatments in the Age of Personalized Medicine: A Comprehensive Review of Potential Radiosensitivity Biomarkers

  2024cites this paper
• Exploring homologous recombination repair and base excision repair pathway genes for possible diagnostic markers in hematologic malignancies

  2023cites this paper
• Synthesis, molecular docking of new amide thiazolidine derived from isoniazid and studying their biological activity against cancer cells

  2023influential citation
• DNA damage repair and cancer immunotherapy

  2023influential citation
• Functional Immune Cell‐Derived Exosomes Engineered for the Trilogy of Radiotherapy Sensitization

  2022cites this paper
• Glucose Increases STAT3 Activation, Promoting Sustained XRCC1 Expression and Increasing DNA Repair

  2022cites this paper
• "RESET" Effect: Random Extending Sequences Enhance the Trans-Cleavage Activity of CRISPR/Cas12a.

  2022cites this paper
• Synthesis of (4R)‐2‐(3‐hydroxyphenyl)thiazolidine‐4‐carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular docking studies

  2021cites this paper
• A DNAzyme-mediated target-initiated rolling circle amplification strategy based on a microchip platform for the detection of apurinic/apyrimidinic endonuclease 1 at the single-cell level.

  2021cites this paper
• Activated STAT3 Is a Novel Regulator of the XRCC1 Promoter and Selectively Increases XRCC1 Protein Levels in Triple Negative Breast Cancer

  2021cites this paper
• APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival

  2021cites this paper
• XRCC1 Is a Promising Predictive Biomarker and Facilitates Chemo-Resistance in Gallbladder Cancer

  2020cites this paper
• APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNF

  2020cites this paper
• Incidence and outcome of salvage cystectomy after bladder sparing therapy for muscle invasive bladder cancer: a systematic review and meta-analysis

  2020cites this paper
• Non-muscle invasive bladder cancer tissues have increased base excision repair capacity

  2020cites this paper
• Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction

  2020cites this paper
• Association between apurinic/apyrimidinic endonuclease 1 rs1760944 T>G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects

  2019cites this paper
• The challenge of matching assays to biology in DNA damage response biomarkers for response to radiotherapy in bladder cancer.

  2019cites this paper
• Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts

  2018cites this paper
• Dysregulated Expression and Subcellular Localization of Base Excision Repair (BER) Pathway Enzymes in Gallbladder Cancer

  2018cites this paper
• Relationship between expression of XRCC1 and tumor proliferation, migration, invasion, and angiogenesis in glioma

  2018cites this paper
• GADD45α sensitizes cervical cancer cells to radiotherapy via increasing cytoplasmic APE1 level

  2018cites this paper
• Prognostic and predictive role of COX-2, XRCC1 and RASSF1 expression in patients with esophageal squamous cell carcinoma receiving radiotherapy

  2017cites this paper
• Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic

  2017cites this paper
• What Is New in the miRNA World Regarding Osteosarcoma and Chondrosarcoma?

  2017cites this paper
• DNA Base Excision Repair: The Achilles' Heel of Tumour Cells and their Microenvironment?

  2017cites this paper
• Targeting DNA repair pathways for cancer therapy

  2017cites this paper
• Deciphering the disease-related molecular networks using urine proteomics

  2017cites this paper
• APE1 overexpression promotes the progression of ovarian cancer and serves as a potential therapeutic target

  2016cites this paper
• Chapter 54 – Bladder Cancer

  2016cites this paper
• Real-time monitoring AP site incision caused by APE1 using a modified hybridization probe

  2016cites this paper
• The role of AIMP3, a putative tumour suppressor gene, as a predictive biomarker of response to chemo/radiotherapy in vitro and in patients with muscle-invasive bladder cancer.

  2015cites this paper
• Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

  2015cites this paper
• Morphological effects of mitomycin C on urothelial responses to experimentally‐induced urethral stricture in rats

  2015cites this paper
• Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma

  2015cites this paper
• Editorial Comment to Morphological effects of mitomycin C on urothelial responses to experimentally‐induced urethral stricture in rats

  2015cites this paper
• Summary of the 8th Annual Bladder Cancer Think Tank: Collaborating to move research forward.

  2015cites this paper
• Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder

  2015cites this paper
• Loss of XRCC1 confers a metastatic phenotype to melanoma cells and is associated with poor survival in patients with melanoma

  2014cites this paper
• DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development.

  2014cites this paper
• Induction of Apurinic Endonuclease 1 Overexpression by Endoplasmic Reticulum Stress in Hepatoma Cells

  2014cites this paper
• Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma

  2014cites this paper
• Molecular mechanisms of chemoresistance in osteosarcoma (Review)

  2014cites this paper
• miR-513a-5p regulates radiosensitivity of osteosarcoma by targeting human apurinic/apyrimidinic endonuclease

  2014cites this paper
• Human Apurinic/Apyrimidinic Endonuclease 1

  2014cites this paper
• Aberrant expression of redox protein Ape1 in colon cancer stem cells

  2014cites this paper
• APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions

  2014cites this paper
• XRCC1 rs25487 polymorphism predicts the survival of patients after postoperative radiotherapy and adjuvant chemotherapy for breast cancer.

  2014cites this paper
• ERCC1 expression and tumor regression predict survival in esophageal squamous cell carcinoma patients receiving combined trimodality therapy.

  2014cites this paper
• Comet assay measures of DNA damage are predictive of bladder cancer cell treatment sensitivity in vitro and outcome in vivo

  2014cites this paper
• Colon cancer progression is driven by APEX1-mediated upregulation of Jagged.

  2013cites this paper
• ERCC1 and XRCC1 expression predicts survival in bladder cancer patients receiving combined trimodality therapy.

  2013influential citation
• The Relationship Between DNA-Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy

  2013cites this paper
• OXIDATIVE DAMAGE TO DNA IN ALZHEIMER'S DISEASE

  2013cites this paper
• DNA Base Excision Repair: Evolving Biomarkers for Personalized Therapies in Cancer

  2013cites this paper
• Association between XRCC1 and XRCC3 Polymorphisms with Lung Cancer Risk: A Meta-Analysis from Case-Control Studies

  2013cites this paper
• A Bioinformatics Filtering Strategy for Identifying Radiation Response Biomarker Candidates

  2012cites this paper
• Prognostic and predictive role of JWA and XRCC1 expression in gastric cancer

  2012cites this paper
• Mass Spectrometric Approaches to Probing the Redox Function of Ape1

  2012cites this paper
• DNA repair in bladder cancer predisposition and radiotherapy treatment response

  2012cites this paper
• Predicting chemosensitivity in osteosarcoma prior to chemotherapy: An investigational study of biomarkers with immunohistochemistry.

  2012cites this paper
• Prognostic and Predictive Role of JWA and XRCC1 Expressions in Gastric Cancer

  2012cites this paper
• Prognostic and predictive role of JWA and XRCC 1 expression in gastric cancer

  2012cites this paper
• Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

  2011cites this paper
• Human Apurinic/Apyrimidinic Endonuclease is a Novel Drug Target in Cancer

  2011cites this paper
• Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer.

  2010cites this paper
• Targeting base excision repair as a sensitization strategy in radiotherapy.

  2010cites this paper
• MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.

  2010cites this paper
• APEX1 Gene Amplification and Its Protein Overexpression in Osteosarcoma: Correlation with Recurrence, Metastasis, and Survival

  2010cites this paper
• Cancer esearch ical Studies E 11 Expression Is Predictive of Cause-Specific Survival wing Radical Radiotherapy for Muscle-Invasive R der Cancer

  2010cites this paper
• A functional −77T>C polymorphism in XRCC1 is associated with risk of breast cancer

  2010cites this paper
• Apurinic/Apyrimidinic Endonuclease/Redox Effector Factor-1(APE/Ref-1): A Unique Target for the Prevention and Treatment of Human Melanoma

  2009cites this paper
• Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics

  2009cites this paper
• A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk.

  2008cites this paper
• Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

  2008cites this paper
• Radiotherapy predictive assays

  2007cites this paper
• Multifunctional human apurinic/apyrimidinic endonuclease 1: Role of additional functions

  2007cites this paper
• Effect of Genetic Polymorphisms on Urinary Bladder Neoplasms

  2007cites this paper
• Polymorphisms in XPD, XPC and the risk of death in patients with urinary bladder neoplasms

  2007cites this paper
• Genetic Polymorphisms of DNA Repair Gene: XRCC1 Pro206Pro and Gln632Gln in a Chinese Han Population

  2007influential citation
• Epidermal growth factor receptor status predicts local response to radical radiotherapy in muscle-invasive bladder cancer.

  2006cites this paper
• Single nucleotide polymorphisms in DNA repair genes might be prognostic factors in muscle-invasive bladder cancer patients treated with chemoradiotherapy

  2006influential citation
• SET complex in serous epithelial ovarian cancer

  2006cites this paper
• Bibliography. Current world literature. Bladder cancer.

  2006cites this paper
• Trimodality treatment and selective organ preservation for bladder cancer.

  2006cites this paper