Gene Expression Profiling after Radiation-Induced DNA Damage Is Strongly Predictive of BRCA1 Mutation Carrier Status

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Clinical Cancer Research

• Publication date

  2004-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-1067-3PMID 14871973
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A subset of ATM‐ and ATR‐dependent phosphorylation events requires the BRCA1 protein

  2003cited by this paper
• BRCA1 transactivates the cyclin-dependent kinase inhibitor p27Kip1

  2002cited by this paper
• Analyzing array data using supervised methods.

  2002cited by this paper
• Genesis: cluster analysis of microarray data

  2002cited by this paper
• Cancer susceptibility and the functions of BRCA1 and BRCA2.

  2002cited by this paper
• The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.

  2002cited by this paper
• BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

  2002influential reference
• Review Cancer Susceptibility and the Functions of BRCA1 and BRCA2

  2002cited by this paper
• Molecular portraits and the family tree of cancer

  2002cited by this paper
• Gene expression profiling predicts clinical outcome of breast cancer

  2002cited by this paper
• Gene-expression profiles in hereditary breast cancer.

  2001cited by this paper
• Gene-expression profiles in hereditary breast cancer.

  2001cited by this paper
• Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential.

  2001cited by this paper
• Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

  2001cited by this paper
• Predicting the clinical status of human breast cancer by using gene expression profiles

  2001cited by this paper
• Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage.

  2000cited by this paper
• BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression*

  2000cited by this paper
• Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.

  1999cited by this paper
• Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 in epithelial ovarian cancer.

  1999cited by this paper
• Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.

  1999cited by this paper
• Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer

  1997cited by this paper
• The contribution of inherited predisposition to cancer incidence.

  1990cited by this paper

• BRCA1 Variant Assessment Using a Simple Analytic Assay.

  2022cites this paper
• Increased gene expression variability in BRCA1-associated and basal-like breast tumours

  2021cites this paper
• Gene Expression Profiles Reveal Extracellular Matrix and Inflammatory Signaling in Radiation-Induced Premature Differentiation of Human Fibroblast in vitro

  2021cites this paper
• Genome-Wide Gene Expression Analyses of BRCA1- and BRCA2-Associated Breast and Ovarian Tumours

  2020influential citation
• SYK expression level distinguishes control from BRCA1-mutated lymphocytes

  2018cites this paper
• DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers

  2015cites this paper
• BRCA1 Haploinsufficiency Leads to Altered Expression of Genes Involved in Cellular Proliferation and Development

  2014influential citation
• A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity

  2014cites this paper
• Determination of Molecular Markers for BRCA1 and BRCA2 Heterozygosity Using Gene Expression Profiling

  2013influential citation
• The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy

  2013cites this paper
• A guide for functional analysis of BRCA1 variants of uncertain significance

  2012cites this paper
• Improving the risk assessment of inherited breast and ovarian cancer : clinical significance of BRCA1/2 variants and risk modifiers

  2012cites this paper
• High RAD51 mRNA expression characterize estrogen receptor‐positive/progesteron receptor‐negative breast cancer and is associated with patient's outcome

  2011cites this paper
• Ionizing radiation induced signaling of DNA damage response molecules in RAW 264.7 and CD4+ T cells

  2011cites this paper
• A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest

  2011cites this paper
• Use of DNA–Damaging Agents and RNA Pooling to Assess Expression Profiles Associated with BRCA1 and BRCA2 Mutation Status in Familial Breast Cancer Patients

  2010cites this paper
• Use of Gene Expression Profiles of Peripheral Blood Lymphocytes to Distinguish BRCA1 Mutation Carriers in High Risk Breast Cancer Families

  2009cites this paper
• Molecular profiles of hereditary epithelial ovarian cancers and their implications for the biology of this disease

  2009cites this paper
• Fluorescent oligonucleotides can serve as suitable alternatives to radiolabeled oligonucleotides.

  2009cites this paper
• The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays

  2009influential citation
• BRCA1 and BRCA2 Missense Variants of High and Low Clinical Significance Influence Lymphoblastoid Cell Line Post-Irradiation Gene Expression

  2008cites this paper
• Radiation-Induced Somatic Mutations by Whole Genome Sequencing from Normal Organoids

  2008cites this paper
• TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer

  2007cites this paper
• The application of differential display as a gene profiling tool.

  2007cites this paper
• A Marfan syndrome gene expression phenotype in cultured skin fibroblasts

  2007cites this paper
• Gene expression arrays as a tool to unravel mechanisms of normal tissue radiation injury and prediction of response.

  2007cites this paper
• Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell-line phenotypic variability

  2007cites this paper
• The genomics revolution and radiotherapy.

  2007cites this paper
• Accurate Prediction of BRCA1 and BRCA2 Heterozygous Genotype Using Expression Profiling after Induced DNA Damage

  2006cites this paper
• Effects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations

  2006cites this paper
• High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?

  2006cites this paper
• DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers

  2006cites this paper
• Radiobiology of breast cancer.

  2006cites this paper
• Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations

  2006cites this paper
• BRCA1 regulation of transcription.

  2006cites this paper
• Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer.

  2006cites this paper
• Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice.

  2005cites this paper
• Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts.

  2005cites this paper
• Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers

  2005cites this paper