The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Current Biology

• Publication date

  2007-02-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CUB.2006.12.048PMID 17291760PMCID PMC1839861
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stimulation of DNA Strand Exchange by the Human TBPIP/Hop2-Mnd1 Complex*

  2006cited by this paper
• Coordinating the events of the meiotic prophase.

  2005cited by this paper
• Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

  2005cited by this paper
• Sex, not genotype, determines recombination levels in mice.

  2005cited by this paper
• Meiotic synapsis proceeds from a limited number of subtelomeric sites in the human male.

  2005cited by this paper
• The Rad50 hook domain is a critical determinant of Mre11 complex functions

  2005cited by this paper
• Association of Mre11p with double-strand break sites during yeast meiosis.

  2004cited by this paper
• Mre11 Deficiency in Arabidopsis Is Associated with Chromosomal Instability in Somatic Cells and Spo11-Dependent Genome Fragmentation during Meiosis

  2004cited by this paper
• Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation.

  2004cited by this paper
• Where the crossovers are: recombination distributions in mammals

  2004cited by this paper
• Conserved and Nonconserved Proteins for Meiotic DNA Breakage and Repair in Yeasts

  2004cited by this paper
• Variation in human meiotic recombination.

  2004cited by this paper
• Early Decision: Meiotic Crossover Interference prior to Stable Strand Exchange and Synapsis

  2004cited by this paper
• Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination

  2004cited by this paper
• Roles of RecA homologues Rad51 and Dmc1 during meiotic recombination

  2004cited by this paper
• Meiosis: when even two is a crowd.

  2003cited by this paper
• Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice

  2003cited by this paper
• Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.

  2003cited by this paper
• Telomere dynamics unique to meiotic prophase: formation and significance of the bouquet

  2003cited by this paper
• Covariation of Synaptonemal Complex Length and Mammalian Meiotic Exchange Rates

  2002cited by this paper
• Meiotic arrest and aneuploidy in MLH3-deficient mice

  2002cited by this paper
• The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.

  2002cited by this paper
• The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

  2002cited by this paper
• The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression.

  2002cited by this paper
• A murine model of Nijmegen breakage syndrome.

  2002cited by this paper
• Recombinational DNA double-strand breaks in mice precede synapsis

  2001cited by this paper
• A DNA damage response pathway controlled by Tel1 and the Mre11 complex.

  2001cited by this paper
• Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

  2001cited by this paper
• Meiotic recombination frequencies are affected by nutritional states in Saccharomyces cerevisiae

  2001cited by this paper
• A bouquet makes ends meet

  2001cited by this paper
• Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation.

  1999cited by this paper
• Chromosomal Influence on Meiotic Spindle Assembly: Abnormal Meiosis I in Female Mlh1 Mutant Mice

  1999cited by this paper
• Distribution of crossing over on mouse synaptonemal complexes using immunofluorescent localization of MLH1 protein.

  1999cited by this paper
• Crossing over analysis at pachytene in man

  1998cited by this paper
• Complex formation and functional versatility of Mre11 of budding yeast in recombination.

  1998cited by this paper
• A Novel mre11 Mutation Impairs Processing of Double-Strand Breaks of DNA during Both Mitosis and Meiosis

  1998cited by this paper
• Changes in protein composition of meiotic nodules during mammalian meiosis.

  1998cited by this paper
• Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats.

  1997cited by this paper
• SHORT COMMUNICATIONS A drying-down technique for the spreading of mammalian meiocytes from the male and female germline

  1997cited by this paper
• Distribution of the Rad51 recombinase in human and mouse spermatocytes

  1997cited by this paper
• mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis.

  1997cited by this paper
• Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells.

  1997cited by this paper
• Presynaptic association of Rad51 protein with selected sites in meiotic chromatin.

  1996cited by this paper
• Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

  1996cited by this paper
• Meiotic pachytene arrest in MLH1-deficient mice.

  1996cited by this paper
• Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro.

  1996cited by this paper
• Dynamic changes in Rad51 distribution on chromatin during meiosis in male and female vertebrates

  1995cited by this paper
• Crossover interference is abolished in the absence of a synaptonemal complex protein.

  1994cited by this paper
• A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae.

  1990cited by this paper
• Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination.

  1990cited by this paper
• AN AIR-DRYING METHOD FOR MEIOTIC PREPARATIONS FROM MAMMALIAN TESTES.

  1964cited by this paper
• THE DEVELOPMENT OF SOME EXTERNAL FEATURES IN MOUSE EMBRYOS

  1943cited by this paper

• Mechanism and potential therapeutic strategies of genetic abnormalities involved in deoxyribonucleic acid double-strand breaks leading to the development of human non-obstructive azoospermia

  2026cites this paper
• MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice

  2026cites this paper
• Mouse MRE11-RAD50-NBS1 is needed to start and extend meiotic DNA end resection

  2025cites this paper
• The MRE11-RAD50-NBS1 complex both starts and extends DNA end resection in mouse meiosis

  2024cites this paper
• MRE11 is essential for the long‐term viability of undifferentiated spermatogonia

  2024cites this paper
• Null Rad50 mutation in mouse germ cells causes reduced DSB formation, abnormal DSB end resection, and complete loss of germ cells.

  2024cites this paper
• Genetic control of meiosis surveillance mechanisms in mammals

  2023cites this paper
• Divergence and conservation of the meiotic recombination machinery

  2023cites this paper
• Large Intra-Age Group Variation in Chromosome Abnormalities in Human Blastocysts

  2021cites this paper
• Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans

  2021cites this paper
• Decreased expression of MRE11 and RAD50 in testes from humans with spermatogenic failure

  2020cites this paper
• NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis

  2020cites this paper
• NAD+-dependent deacetylase SIRT1 is essential for meiotic progression and controls repair-recombination efficiency

  2019cites this paper
• Role of HP1β during spermatogenesis and DNA replication

  2019cites this paper
• Regulation of the oocyte pool in mammals

  2019cites this paper
• Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?

  2019cites this paper
• GCNA interacts with Spartan and Topoisomerase II to regulate genome stability

  2019cites this paper
• Clustering of Pan- and Core-genome of Lactobacillus provides Novel Evolutionary Insights for Differentiation

  2018cites this paper
• The capacity of oocytes for DNA repair

  2018cites this paper
• Structured illumination microscopy imaging reveals localization of replication protein A between chromosome lateral elements during mammalian meiosis

  2018cites this paper
• Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis

  2018cites this paper
• Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte.

  2017cites this paper
• Phenotypic and phylogenetic studies of benthic mat-forming cyanobacteria on the NW Svalbard

  2017cites this paper
• The Dark Side of the Mushroom Spring Microbial Mat: Life in the Shadow of Chlorophototrophs. I. Microbial Diversity Based on 16S rRNA Gene Amplicons and Metagenomic Sequencing

  2016cites this paper
• Altered Crossover Distribution and Frequency in Spermatocytes of Infertile Men with Azoospermia

  2016cites this paper
• The molecular dimension of microbial species: 1. Ecological distinctions among, and homogeneity within, putative ecotypes of Synechococcus inhabiting the cyanobacterial mat of Mushroom Spring, Yellowstone National Park

  2015cites this paper
• Anaplasma marginale major surface protein 1a: a marker of strain diversity with implications for control of bovine anaplasmosis.

  2015cites this paper
• Characterization of MRE11 Mutants Provides Insight into Human Genetic Disease, Cancer, and Clinical Intervention.

  2015cites this paper
• Interdependence of the rad50 hook and globular domain functions.

  2015cites this paper
• The ATM Signaling Cascade Promotes Recombination-Dependent Pachytene Arrest in Mouse Spermatocytes

  2015cites this paper
• Chapter 1 – Mammalian Meiosis

  2015cites this paper
• Functions of the MRE11 complex in the development and maintenance of oocytes

  2015cites this paper
• Mechanism and regulation of meiotic recombination initiation.

  2014cites this paper
• Meiotic Functions Dispensable for Other MRN-Dependent Removal Is Spo11 Removal, but Rec12 Spo11 Activity Are Required for Rec12 Nuclease Mre11 and Rad32 CtIP Ctp1

  2014cites this paper
• Investigating nephronophthisis using a novel murine and cell model

  2014cites this paper
• A Mutation in the FHA Domain of Coprinus cinereus Nbs1 Leads to Spo11-Independent Meiotic Recombination and Chromosome Segregation

  2013cites this paper
• The impact of environmental stress on male reproductive development in plants: biological processes and molecular mechanisms

  2013cites this paper
• Initiation of meiotic recombination: how and where? Conservation and specificities among eukaryotes.

  2013cites this paper
• The ATM signaling network in development and disease

  2013influential citation
• The molecular evolution of reproduction in animals: insights from sexual and asexual rotifers

  2013cites this paper
• Meiotic Genetics Moves Forward with SPATA22 (repro42)

  2012cites this paper
• The tricky path to recombining X and Y chromosomes in meiosis

  2012cites this paper
• Meiotic double strand breaks repair in sexually reproducing eukaryotes: we are not all equal.

  2012cites this paper
• Altered distribution of MLH1 foci is associated with changes in cohesins and chromosome axis compaction in an asynaptic mutant of tomato

  2012cites this paper
• Programmed phosphorylation of histone H2AX precedes a phase of DNA double-strand break-independent synapsis in mouse meiosis.

  2012cites this paper
• Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase

  2011cites this paper
• Recombination and Population Structure in Salmonella enterica

  2011cites this paper
• Role of Polycomb Group Protein Cbx2/M33 in Meiosis Onset and Maintenance of Chromosome Stability in the Mammalian Germline

  2011cites this paper
• The MRE11 complex: starting from the ends

  2011cites this paper
• Development of Defined Biological Models for Complex Radiation-Induced DNA Lesions Using Homing Endonucleases and Transposon Technology: Feasibility and Initial Characterization

  2011cites this paper
• Detection of recombination events in bacterial genomes from large population samples

  2011cites this paper
• Reproductive Phenotypes of Mouse Models Illuminate Human Infertility

  2011cites this paper
• A Robust Procedure for Comparing Multiple Means under Heteroscedasticity in Unbalanced Designs

  2010cites this paper
• Ecology of Speciation in the Genus Bacillus

  2010cites this paper
• DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis

  2010cites this paper
• Mouse TRIP13/PCH2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during Meiosis

  2010cites this paper
• MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena

  2010cites this paper
• The MRN complex in double‐strand break repair and telomere maintenance

  2010cites this paper
• Influence of Molecular Resolution on Sequence-Based Discovery of Ecological Diversity among Synechococcus Populations in an Alkaline Siliceous Hot Spring Microbial Mat

  2010cites this paper
• Nondisjunction and chromosomal anomalies La no disyunción y las anomalías cromosómicas

  2010cites this paper
• La no disyunción y las anomalías cromosómicas

  2010cites this paper
• Nondisjunction and chromosomal anomalies

  2010cites this paper
• Initiation of Meiotic Recombination in Mammals

  2010cites this paper
• Global distribution of cyanobacterial ecotypes in the cold biosphere

  2010cites this paper
• Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes.

  2009cites this paper
• Meiotic Functions Dispensable for Other MRN-Dependent Removal IsSpo 11 Removal , but Rec 12 Spo 11 Activity Are Required for Rec 12 NucleaseMre 11 and Rad 32 CtIPCtp

  2009cites this paper
• Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex

  2009cites this paper
• Fertility defects revealing germline biallelic nonsense NBN mutations

  2009cites this paper
• Ctp1CtIP and Rad32Mre11 Nuclease Activity Are Required for Rec12Spo11 Removal, but Rec12Spo11 Removal Is Dispensable for Other MRN-Dependent Meiotic Functions

  2009cites this paper
• Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis

  2009cites this paper
• Distribution of MLH1 foci and inter-focal distances in spermatocytes of infertile men.

  2009cites this paper
• Ctp 1 CtIP and Rad 32 Mre 11 Nuclease Activity Are Required for Rec 12 Spo 11 Removal , but Rec 12 Spo 11 Removal Is Dispensable for Other MRN-Dependent Meiotic Functions

  2009cites this paper
• Ctp1 CtIP and Rad32 Mre11 Nuclease Activity Are Required for Rec12 Spo11 Removal, but Rec12 Spo11 Removal Is Dispensable for Other MRN-Dependent Meiotic Functions (cid:1)

  2009cites this paper
• ATM Promotes the Obligate XY Crossover and both Crossover Control and Chromosome Axis Integrity on Autosomes

  2008cites this paper
• Cytological analysis of MRE11 protein during early meiotic prophase I in Arabidopsis and tomato

  2008cites this paper
• Proteins Involved in Meiotic Recombination: A Role in Male Infertility?

  2008cites this paper
• Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies

  2008cites this paper
• Coprinus cinereus rad50 Mutants Reveal an Essential Structural Role for Rad50 in Axial Element and Synaptonemal Complex Formation, Homolog Pairing and Meiotic Recombination

  2008cites this paper
• The Mre11 Nuclease Complex

  2008cites this paper
• Resource Partitioning and Sympatric Differentiation Among Closely Related Bacterioplankton

  2008cites this paper
• The biology of infertility: research advances and clinical challenges

  2008cites this paper
• ZIP4H (TEX11) Deficiency in the Mouse Impairs Meiotic Double Strand Break Repair and the Regulation of Crossing Over

  2008influential citation
• The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome

  2007cites this paper
• The multiple roles of the Mre11 complex for meiotic recombination

  2007cites this paper
• Excess Single-Stranded DNA Inhibits Meiotic Double-Strand Break Repair

  2007cites this paper
• The origin of human aneuploidy: where we have been, where we are going.

  2007cites this paper
• Phylogenetic Ecology of the Freshwater Actinobacteria acI Lineage

  2007cites this paper
• Uva-dare (digital Academic Repository) Mouse Trip13/pch2 Is Required for Recombination and Normal Higher-order Chromosome Structure during Meiosis Mouse Trip13/pch2 Is Required for Recombination and Normal Higher-order Chromosome Structure during Meiosis

  year unknowncites this paper