Tafamidis improves bladder function in hereditary ATTR amyloidosis

A 71‐year‐old man with a family history of hereditary ATTR (ATTRm) amyloidosis, began to have sensory disturbance in his extremities at age 65. Although he had no cardiac or gastrointestinal symptoms, a head‐up tilt test, ultrasound echography, myocardial scintigraphy, and upper gastric biopsy showed abnormality. This, together with the findings of nerve conduction study and gene analysis, confirmed a diagnosis of ATTRm. He was started on 20 mg/day tafamidis meglumine, a transthyretin tetramer stabilizer, and 0.5 mg/day clonazepam, a GABAergic drug. Somatic nerve functions were unchanged or slightly worsened. However, his bladder autonomic nerve function, as assessed by a urodynamic test, showed mild improvements characterized by recovery of bladder sensation and contractility.

• Publication year

  2018

• Venue

  Neurology and Clinical Neuroscience

• Publication date

  2018-11-14

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/ncn3.12246
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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