Antioxidant effect of hydralazine on retinal pigment epithelial cells and its potential use in the therapy of age-related macular degeneration

No abstract is available for this paper.

• Publication year

  2008

• Venue

  International Journal of Ophthalmology

• Publication date

  2008-06-25

• Fields of study

  Medicine

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Aging of the Retinal Pigment Epithelium

  2008cited by this paper
• Effect of hydrogen peroxide production and the Fenton reaction on membrane composition of Streptococcus pneumoniae.

  2007cited by this paper
• Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels.

  2006cited by this paper
• Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide.

  2006cited by this paper
• The retinal pigment epithelium in visual function.

  2005cited by this paper
• The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine.

  2005cited by this paper
• Oxidative stress in Alzheimer's disease.

  2005cited by this paper
• Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure.

  2005cited by this paper
• Angiotensin type 2 receptor neuroprotection against chemical hypoxia is dependent on the delayed rectifier K+ channel, Na+/Ca2+ exchanger and Na+/K+ ATPase in primary cortical cultures.

  2004cited by this paper
• Influence of oxygen free radicals and free radical scavengers on the growth behaviour and oxidative tissue damage of bovine retinal pigment epithelium cells in vitro

  2004cited by this paper
• Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations.

  2003cited by this paper
• Angiotensin protects cortical neurons from hypoxic-induced apoptosis via the angiotensin type 2 receptor.

  2002cited by this paper
• An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch’s membrane interface in aging and age-related macular degeneration.Hageman GS,∗ Luthert PJ, Chong NHV, Johnson LV, Anderson DH, Mullins RF. Prog Ret Eye Res 2001:20:705–732.

  2002cited by this paper
• tert-Butyl hydroperoxide-induced lipid signaling in hepatocytes: involvement of glutathione and free radicals.

  2001cited by this paper
• Sodium azide treatment decreases striatal and cortical concentrations of alpha-tocopherol in rats.

  2001cited by this paper
• In vivo metabolism of tert-butyl hydroperoxide to methyl radicals. EPR spin-trapping and DNA methylation studies.

  2000cited by this paper
• The role of oxidative stress in the pathogenesis of age-related macular degeneration.

  2000cited by this paper
• [Macular disease].

  2000cited by this paper
• Oxidative damage and protection of the RPE.

  2000cited by this paper
• Age-related macular degeneration.

  2000cited by this paper
• Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes*

  1998cited by this paper
• Characterization of a chemical anoxia model in cerebellar granule neurons using sodium azide: Protection by nifedipine and MK‐801

  1996cited by this paper
• ESR spin trapping investigation of radical formation from the reaction between hematin and tert-Butyl hydroperoxide.

  1996cited by this paper
• Hypoxic Induction of Endothelial Cell Growth Factors in Retinal Cells: Identification and Characterization of Vascular Endothelial Growth Factor (VEGF) as the Mitogen

  1995cited by this paper
• Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen.

  1995cited by this paper
• Inhibition of calcium release from the sarcoplasmic reticulum of rabbit aorta by hydralazine

  1995cited by this paper
• Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epithelium.

  1994cited by this paper
• Astrocyte glutamate uptake during chemical hypoxia in vitro.

  1992cited by this paper
• Interphotoreceptor retinoid binding protein induced experimental autoimmune uveitis: an immunophenotypic analysis using alkaline phosphatase anti-alkaline phosphatase staining, dual immunofluorescence and confocal microscopy.

  1992cited by this paper
• Proliferative Vitreoretinopathy: Lymphocytes in Epiretinal Membranes

  1992cited by this paper
• Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration.

  1991cited by this paper
• Human retinal pigment epithelium contains two distinct species of superoxide dismutase.

  1990cited by this paper
• CELL LOSS IN THE AGING RETINA

  1989cited by this paper
• Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with rat liver microsomal fractions.

  1989cited by this paper
• Deleterious Effects of Oxygen Radicals in Ischemia/Reperfusion Resolved and Unresolved Issues

  1989cited by this paper
• Mechanism of direct cardiostimulating actions of hydralazine.

  1987cited by this paper
• The oxygen free radical system: a fundamental mechanism in the production of myocardial necrosis.

  1986cited by this paper
• Oxygen-derived free radicals in postischemic tissue injury.

  1985cited by this paper
• Polymorphonuclear leukocyte-mediated cell and tissue injury: oxygen metabolites and their relations to human disease.

  1985cited by this paper
• Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes.

  1985cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975.

  1980cited by this paper
• The physiologic and pharmacologic basis for the clinical treatment of hypertension.

  1967cited by this paper
• CLINICAL AND EXPERIMENTAL STUDIES ON THE HYDRALAZINE SYNDROME AND ITS RELATIONSHIP TO SYSTEMIC LUPUS ERYTHEMATOSUS

  1967cited by this paper
• Insight Review Articles

  year unknowncited by this paper

• Protective effect of gypenoside LXXV from Gynostemma pentaphyllum against oxidative stress-induced retinal degeneration in vitro and in vivo

  2021cites this paper
• Therapeutic Effects of Hydralazine on Renal Ischemia-Reperfusion Injury in Rat.

  2019cites this paper
• 14 Treatments of Dry AMD

  2018influential citation
• Etiology and pathogenesis of dry AMD

  2017influential citation
• In vitro and in vivo study of hydralazine, a potential anti-angiogenic agent.

  2016cites this paper
• Treatments of Dry AMD

  2012cites this paper
• Pharmacological treatment of dry age-related macular degeneration (AMD)

  2011cites this paper