Pharmacovigilance in Special Populations

Abstract The number and proportion of elderly people continue to increase worldwide. The majority of the elderly have multiple medical conditions, often the result of changes in biological processes associated with aging. This leads to the use of multiple medications and increased risk for drug–drug interactions, drug–disease interactions, medication errors, and adverse drug reactions. This chapter highlights several important factors to consider when conducting safety evaluations for medicinal products used by elderly patients. These include age-related changes in pharmacokinetic and pharmacodynamic effects and the need for specialized data collection and analysis of elderly patient cohorts throughout the product life cycle. This chapter also addresses the importance of communicating risks and measures to minimize the risks to the growing elderly population.

• Publication year

  2019

• Venue

  Pharmacovigilance: A Practical Approach

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/B978-0-323-58116-5.00010-9
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Epigenetics and aging

  2016cited by this paper
• Changes in Prescription and Over-the-Counter Medication and Dietary Supplement Use Among Older Adults in the United States, 2005 vs 2011.

  2016cited by this paper
• Pharmacokinetic and Pharmacodynamic Considerations in Elderly Population

  2016cited by this paper
• Aging and liver disease.

  2015cited by this paper
• Prevalence, Determinants and Patterns of Multimorbidity in Primary Care: A Systematic Review of Observational Studies

  2014cited by this paper
• Geroscience: linking aging to chronic disease.

  2014cited by this paper
• Drug-disease interaction in elderly patients in family practice.

  2014cited by this paper
• Medication prescribing in frail older people

  2013cited by this paper
• Multimorbidity in older adults.

  2013cited by this paper
• Normal cognitive aging.

  2013cited by this paper
• Drug metabolism in older people--a key consideration in achieving optimal outcomes with medicines.

  2012cited by this paper
• Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study.

  2012cited by this paper
• Pharmacokinetics and pharmacodynamic changes associated with aging and implications for drug therapy.

  2012cited by this paper
• Patterns of Multimorbidity in Elderly Veterans

  2012cited by this paper
• Age-related changes in pharmacokinetics.

  2011cited by this paper
• Liver Regeneration and Aging: A Current Perspective

  2011cited by this paper
• How important are drug-drug interactions to the health of older adults?

  2011cited by this paper
• Theories and mechanisms of aging.

  2011cited by this paper
• Aging and Physiological Changes of the Kidneys Including Changes in Glomerular Filtration Rate

  2011cited by this paper
• Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions.

  2010cited by this paper
• The Blood–Brain Barrier: Geriatric Relevance of a Critical Brain–Body Interface

  2010cited by this paper
• Incident use and outcomes associated with potentially inappropriate medication use in older adults.

  2010cited by this paper
• Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration.

  2009cited by this paper
• Cognitive impairments in chronic heart failure: a case controlled study.

  2009cited by this paper
• Predictors of Medication Errors Among Elderly Hospitalized Patients

  2008cited by this paper
• ADME-tox issues for the elderly

  2008cited by this paper
• Changes in Pharmacokinetics and Pharmacodynamics in the Elderly Patient

  2007cited by this paper
• Pharmacodynamics in older adults: a review.

  2007cited by this paper
• National surveillance of emergency department visits for outpatient adverse drug events.

  2006cited by this paper
• Drug metabolism and ageing

  2005cited by this paper
• Drug metabolism and ageing.

  2004cited by this paper
• Aging Biology and Geriatric Clinical Pharmacology

  2004cited by this paper
• Neuroendocrine mechanisms and cardiovascular homeostasis in the elderly

  2004cited by this paper
• When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly.

  2003cited by this paper
• Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications.

  2003cited by this paper
• Side effects of opioids during short‐term administration: Effect of age, gender, and race

  2003cited by this paper
• Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey.

  2002cited by this paper
• Adverse Drug Reactions as Cause of Hospital Admissions: Results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA)

  2002cited by this paper
• Liver Function and Phase I Drug Metabolism in the Elderly

  2001cited by this paper
• Age-Dependent Changes of the Kidneys: Pharmacological Implications

  1999cited by this paper
• The efficacy, safety, and tolerability of antipsychotics in the elderly.

  1999cited by this paper
• Sonographic measurement of absolute and relative renal length in adults

  1998cited by this paper
• The Aging Liver

  1998cited by this paper
• Drug Dosage in the Elderly

  1998cited by this paper
• Drug Prescribing for Elderly Patients

  1995cited by this paper
• Drug Actions Interactions & Reactions

  1977cited by this paper
• Adult lean body mass declines with age: some longitudinal observations.

  1970cited by this paper

• No citing papers are available for this paper.