Insulin regulates Presenilin 1 localization via PI3K/Akt signaling.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neuroscience Letters

• Publication date

  2010-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neulet.2010.07.055PMID 20696212
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid.

  2009cited by this paper
• N‐cadherin‐based adhesion enhances Aβ release and decreases Aβ42/40 ratio

  2009cited by this paper
• Amyloid beta oligomers induce impairment of neuronal insulin receptors

  2008cited by this paper
• Metabolic syndrome and the role of dietary lifestyles in Alzheimer’s disease

  2008cited by this paper
• Intranasal insulin improves cognition and modulates β-amyloid in early AD

  2008cited by this paper
• Soluble Aβ Inhibits Specific Signal Transduction Cascades Common to the Insulin Receptor Pathway*

  2007cited by this paper
• GSK3β Activity Modifies the Localization and Function of Presenilin 1*

  2007influential reference
• Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.

  2006cited by this paper
• Presenilin‐1 is an unprimed glycogen synthase kinase‐3β substrate

  2006cited by this paper
• Risk of dementia in diabetes mellitus: a systematic review.

  2006influential reference
• Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

  2006cited by this paper
• IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A

  2005cited by this paper
• Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study.

  2005cited by this paper
• Glycogen synthase kinase 3: a drug target for CNS therapies

  2004cited by this paper
• Role for neuronal insulin resistance in neurodegenerative diseases.

  2004influential reference
• Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

  2004influential reference
• Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

  2003cited by this paper
• Presenilin 1 mediates retinoic acid‐induced differentiation of SH‐SY5Y cells through facilitation of Wnt signaling

  2003cited by this paper
• The insulin signalling pathway.

  2002cited by this paper
• APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

  2002cited by this paper
• aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

  2002cited by this paper
• aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

  2002cited by this paper
• Substitution of a Glycogen Synthase Kinase-3β Phosphorylation Site in Presenilin 1 Separates Presenilin Function from β-Catenin Signaling*

  2001cited by this paper
• Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.

  2001cited by this paper
• Insulin signalling.

  2001influential reference
• Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

  2000cited by this paper
• The Insulin Signaling Pathway

  1999cited by this paper
• Diabetes mellitus and the risk of dementia

  1999cited by this paper
• Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

  1998cited by this paper
• Risk of dementia: The Rotterdam Study

  1997cited by this paper
• beta-catenin is a target for the ubiquitin-proteasome pathway.

  1997cited by this paper
• Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons*

  1997cited by this paper
• β‐catenin is a target for the ubiquitin–proteasome pathway

  1997cited by this paper
• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

  1995cited by this paper
• Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

  1992cited by this paper
• Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

  1986influential reference
• Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells.

  1985cited by this paper

• Cerebrospinal fluid soluble insulin receptor levels in Alzheimer's disease

  2024cites this paper
• kinase 3 β-mediated

  2023cites this paper
• Effect of GSK3-mediatedPS1 phosphorylation on A production is negatively regulated by IR cleavage

  2022cites this paper
• Title Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

  2020cites this paper
• Cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer's disease: studies in animal models

  2015cites this paper
• Copper enhances APP dimerization and promotes Aβ production.

  2013cites this paper
• The effect of Chinese Jinzhida recipe on the hippocampus in a rat model of diabetes-associated cognitive decline

  2013cites this paper
• The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins.

  2013cites this paper
• Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice*♦

  2012cites this paper
• Gain of function by phosphorylation in Presenilin 1‐mediated regulation of insulin signaling

  2012cites this paper
• Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice.

  2012cites this paper
• Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage.

  2011cites this paper
• Presenilin Regulates Insulin Signaling via a γ-Secretase-independent Mechanism*

  2011cites this paper
• The Phosphatidylinositol 3-Kinase/mTor Pathway as a Therapeutic Target for Brain Aging and Neurodegeneration

  2011cites this paper