Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  European Neuropsychopharmacology

• Publication date

  2013-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.euroneuro.2012.08.003PMID 22910528
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diagnostic and Statistical Manual of Mental Disorders

  2013cited by this paper
• Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression.

  2011cited by this paper
• Review of major measuring instruments in comorbid depression and coronary heart disease.

  2011cited by this paper
• The effect of low-dose omega 3 fatty acids on the treatment of mild to moderate depression in the elderly: a double-blind, randomized, placebo-controlled study

  2011influential reference
• Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: a randomized, double-blind placebo-controlled study.

  2010influential reference
• Epidemiology of Major Depressive Disorder in Iran: a Systematic Review and Meta-Analysis

  2010influential reference
• Effect of Omega-3 Fatty Acids Supplementation on Depressive Symptoms and on Health-Related Quality of Life in the Treatment of Elderly Women with Depression: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

  2010cited by this paper
• A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder.

  2009cited by this paper
• Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: a randomized controlled trial.

  2009cited by this paper
• Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial.

  2009cited by this paper
• EPA but Not DHA Appears To Be Responsible for the Efficacy of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation in Depression: Evidence from a Meta-Analysis of Randomized Controlled Trials

  2009cited by this paper
• A double-blind dose-finding pilot study of docosahexaenoic acid (DHA) for major depressive disorder.

  2008influential reference
• Comparison of Therapeutic Effects of Omega-3 Fatty Acid Eicosapentaenoic Acid and Fluoxetine, Separately and in Combination, in Major Depressive Disorder

  2008cited by this paper
• No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial

  2008influential reference
• The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study.

  2008cited by this paper
• Depression in Parkinson's disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation.

  2008cited by this paper
• Docosahexaenoic acid supplementation induces dose and time dependent oxidative changes in C6 glioma cells

  2007cited by this paper
• Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus.

  2007cited by this paper
• Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial.

  2007cited by this paper
• Modulation of amyloid‐β‐induced and age‐associated changes in rat hippocampus by eicosapentaenoic acid

  2007cited by this paper
• Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats.

  2007cited by this paper
• Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique.

  2006cited by this paper
• Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: Randomised double-blind placebo-controlled study

  2006influential reference
• WITHDRAWN: Treatment discontinuation with selective serotonin reuptake inhibitors (SSRIs) versus tricyclic antidepressants (TCAs).

  2006cited by this paper
• Treatment discontinuation with selective serotonin reuptake inhibitors (SSRIs) versus tricyclic antidepressants (TCAs) (Withdrawn Paper. 2006, art no. CD002791)

  2006cited by this paper
• Effect of arachidonic, eicosapentaenoic and docosahexaenoic acids on the oxidative status of C6 glioma cells

  2005cited by this paper
• Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression.

  2005cited by this paper
• Update on the Biology of Seasonal Affective Disorder

  2005cited by this paper
• Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide‐induced dysfunction in rat hippocampus

  2004cited by this paper
• Subthreshold depression as a risk indicator for major depressive disorder: a systematic review of prospective studies

  2004influential reference
• A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression.

  2003cited by this paper
• Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial.

  2003cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)

  2003cited by this paper
• The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).

  2003cited by this paper
• Is treatment-resistant depression a unique subtype of depression?

  2003cited by this paper
• The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) surveys

  2003cited by this paper
• Randomisation in clinical trials

  2002cited by this paper
• The prevalence, clinical relevance, and public health significance of subthreshold depressions.

  2002cited by this paper
• Excess mortality in depression: a meta-analysis of community studies.

  2002cited by this paper
• Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases

  2002cited by this paper
• Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder.

  2002cited by this paper
• Depression as a predictor for coronary heart disease. a review and meta-analysis.

  2002cited by this paper
• A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs.

  2002influential reference
• Meta-analysis of randomised controlled trials of fluoxetine v. placebo and tricyclic antidepressants in the short-term treatment of major depression

  2000cited by this paper
• Pathophysiology of seasonal affective disorder: a review.

  2000cited by this paper
• Selective serotonin reuptake inhibitors versus tricyclic and heterocyclic antidepressants: comparison of drug adherence.

  2000cited by this paper
• Randomisation in clinical trials

  1999cited by this paper
• Fish consumption and major depression.

  1998cited by this paper
• Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy.

  1995cited by this paper
• High Plasma Concentrations of Cortisol and Thromboxane B2 in Patients With Depression

  1994cited by this paper
• Purification and characterisation of phospholipase A2 from human epidermis.

  1991cited by this paper
• Increased level of salivary prostaglandins in patients with major depression.

  1988cited by this paper
• An inventory for measuring depression.

  1961cited by this paper
• A RATING SCALE FOR DEPRESSION

  1960cited by this paper

• Scientific Opinion on the tolerable upper intake level for supplemental docosahexaenoic acid

  2026cites this paper
• Sex differences in nutritional psychiatry: Are omega-3 fatty acids more effective in women with MDD?

  2025cites this paper
• Association between dietary fat quality indices and mental health across age and sex groups: a cross-sectional study

  2025cites this paper
• Nutraceuticals in the Treatment of Major Depressive Disorder

  2025cites this paper
• Understanding the research landscape of over-the-counter herbal products, dietary supplements, and medications evaluated for depressive symptoms in adults: a scoping review

  2025cites this paper
• Nutraceutical Eicosapentaenoic Acid in Treatment-Resistant Depression: The Psychoneuroimmunity and Clinical Implications.

  2025cites this paper
• Association Between Oral Health-Related Quality of Life and Mental Health Among University Students in Riyadh, Saudi Arabia

  2025cites this paper
• Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta‐Analysis

  2025cites this paper
• The Utility of Prolonged Chronic Unpredictable Stress to Study the Effects of Chronic Fluoxetine, Eicosapentaenoic Acid, and Lipopolysaccharide on Anxiety‐Like Behavior and Hippocampal Transcriptomic Responses in Male Rats

  2025cites this paper
• Incredible Use of Omega-3 Fatty Acids: A Review on Current Use and Future Prospective

  2024cites this paper
• Efficacy and acceptability of anti-inflammatory agents in major depressive disorder: a systematic review and meta-analysis

  2024cites this paper
• The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk

  2023cites this paper
• Impact of Nutrition on Depression: A Review of Some Dietary Components with Antidepressant Effects and Their Mechanism of Action

  2023cites this paper
• Omega-3 supplementation improves depressive symptoms, cognitive function and niacin skin flushing response in adolescent depression: A randomized controlled clinical trial.

  2023cites this paper
• Plasma Phospholipid Polyunsaturated Fatty Acid Associations with Neurocognition

  2023cites this paper
• Prospective study on Maresin-1 and cytokine levels in medication-naïve adolescents with first-episode major depressive disorder

  2023cites this paper
• Current Insights into the Use of Probiotics and Fatty Acids in Alleviating Depression

  2023cites this paper
• Efficacy and safety of n-3 fatty acids supplementation on depression: a systematic review and dose–response meta-analysis of randomised controlled trials

  2023cites this paper
• Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications.

  2023cites this paper
• Dietary Fats and Depressive Symptoms in Italian Adults

  2023cites this paper
• Anti-Inflammatory Treatment Efficacy in Major Depressive Disorder: A Systematic Review of Meta-Analyses

  2023cites this paper
• Dietary fish oil improves autistic behaviors and gut homeostasis by altering the gut microbial composition in a mouse model of fragile X syndrome.

  2023cites this paper
• BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

  2022cites this paper
• Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota

  2022cites this paper
• The Effects of Omega-3 Supplementation on Depression in Adults with Cardiometabolic Disease: A Systematic Review of Randomised Control Trials

  2022cites this paper
• n-3 PUFAs for depression: treatment effect or absence-of-placebo effect?

  2022cites this paper
• Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials

  2022influential citation
• Nutritional support for the body under stress in the era of global challenges to humanity

  2022cites this paper
• Modulation of behavioral and neurochemical responses of adult zebrafish by fluoxetine, eicosapentaenoic acid and lipopolysaccharide in the prolonged chronic unpredictable stress model

  2021cites this paper
• Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid: A Comprehensive Review of the Literature

  2021cites this paper
• Effects of chronic exposure to fluoxetine, eicosapentaenoic acid, and lipopolysaccharide on behavior and hippocampal transcriptome in the rat model of prolonged chronic unpredictable stress

  2021cites this paper
• Effects of chronic exposure to fluoxetine, eicosapentaenoic acid, and lipopolysaccharide on behavior and hippocampal transcriptome in the rat model of prolonged chronic unpredictable stress

  2021cites this paper
• Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression

  2021cites this paper
• Bipolar disorder and eating disorders in sport: a case of comorbidity and review of treatment principles in an elite athlete

  2021cites this paper
• Omega-3 fatty acids for depression in adults.

  2021cites this paper
• ω-3 DPA Protected Neurons from Neuroinflammation by Balancing Microglia M1/M2 Polarizations through Inhibiting NF-κB/MAPK p38 Signaling and Activating Neuron-BDNF-PI3K/AKT Pathways

  2021cites this paper
• Role of dietary factors in the prevention and treatment for depression: an umbrella review of meta-analyses of prospective studies

  2021cites this paper
• Effect of gibberellin, methyl jasmonate and myoinositol on biomass and eicosapentaenoic acid productivities in the eustigmatophyte Monodopsis subterranea CCALA 830

  2020cites this paper
• High-dose omega-3 polyunsaturated fatty acid supplementation might be more superior than low-dose for major depressive disorder in early therapy period: a network meta-analysis

  2020cites this paper
• Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology

  2020cites this paper
• The stress–Wnt-signaling axis: a hypothesis for attention-deficit hyperactivity disorder and therapy approaches

  2020cites this paper
• Evaluation of the effect of insulin sensitivity-enhancing lifestyle- and dietary-related adjuncts on antidepressant treatment response: A systematic review and meta-analysis

  2020cites this paper
• Effect of gibberellin, methyl jasmonate and myoinositol on biomass and eicosapentaenoic acid productivities in the eustigmatophyte Monodopsis subterranea CCALA 830

  2020cites this paper
• Beyond cardiovascular medicine: potential future uses of icosapent ethyl

  2020cites this paper
• Optical analysis of nanoencapsulated food ingredients by color measurement

  2020cites this paper
• International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder

  2019cites this paper
• Omega-3 fatty acids for the treatment of depressive disorders in children and adolescents: a meta-analysis of randomized placebo-controlled trials

  2019cites this paper
• Polyunsaturated Fatty Acids: What is Their Role in Treatment of Psychiatric Disorders?

  2019cites this paper
• DETAILED STUDY PROTOCOL TITLE: Omega-3 Fatty Acids for MDD with High Inflammation: A Personalized Approach

  2019cites this paper
• The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders

  2019cites this paper
• Efficacy of omega-3 PUFAs in depression: A meta-analysis

  2019cites this paper
• Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study.

  2018cites this paper
• Targeting mTORs by omega‐3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?

  2018cites this paper
• Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells

  2018cites this paper
• Popular Herbal and Natural Remedies Used in Psychiatry.

  2018cites this paper
• Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.

  2018influential citation
• Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits.

  2018cites this paper
• Omega-3 polyunsaturated fatty acid supplementation in prevention and treatment of maternal depression: Putative mechanism and recommendation.

  2018cites this paper
• Lipid correlates of antidepressant response to omega-3 polyunsaturated fatty acid supplementation: A pilot study.

  2017cites this paper
• Effect of Fish Oil vs. Resolvin D1, E1, Methyl Esters of Resolvins D1 or D2 on Diabetic Peripheral Neuropathy

  2017cites this paper
• Gender, negative life events and coping on different stages of depression severity: A cross-sectional study among Chinese university students.

  2017cites this paper
• Therapeutic Strategies for Treatment of Inflammation-related Depression

  2017cites this paper
• Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants

  2017cites this paper
• The role of n-3 polyunsaturated fatty acids (n-3PUFAs) in affective disorders.

  2017cites this paper
• Clinical use of nutraceuticals in the adjunctive treatment of depression in mood disorders

  2017cites this paper
• Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review

  2017cites this paper
• Nutritional supplements in depressive disorders.

  2017cites this paper
• DHA, EPA and their combination at various ratios differently modulated Aβ25-35-induced neurotoxicity in SH-SY5Y cells.

  2017cites this paper
• Adjunctive low-dose docosahexaenoic acid (DHA) for major depression: An open-label pilot trial

  2017cites this paper
• Evidence for Inflammation-Associated Depression.

  2016cites this paper
• Role of n-3 ( Omega - 3 ) Polyunsaturated Fatty Acids in Postpartum Depression: Mechanisms and Implications for Prevention and Treatment

  2016cites this paper
• Acupuncture for Ischemic Stroke, Music for Anxiety in Mechanical Ventilation, Essential Fatty Acids for Depression, Mindfulness Meditation for Sleep in Older Adults, Tripterygium wilfordii for Rheumatoid Arthritis.

  2016cites this paper
• Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder

  2016cites this paper
• Are over-the-counter fish oil supplements effective and safe for treating mood disorders? Studies on the top 10 fish oil supplements available in New Zealand

  2016cites this paper
• Comments on Bozzatello et al. Supplementation with Omega-3 Fatty Acids in Psychiatric Disorders: A Review of Literature Data. J. Clin. Med. 2016, 5, 67

  2016cites this paper
• Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.

  2016cites this paper
• The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting separately or synergistically?

  2016cites this paper
• Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression

  2016cites this paper
• A double-blind, randomized controlled clinical trial comparing eicosapentaenoic acid versus docosahexaenoic acid for depression.

  2015cites this paper
• Omega-3 fatty acids and the treatment of depression: a review of scientific evidence

  2015cites this paper
• 25. Omeg a-3 polyunsaturated fatty acid potential for post-traumatic stress and depression

  2015cites this paper
• Important bioactive properties of omega-3 fatty acids

  2015cites this paper
• Omega-3 Fatty Acids for Major Depressive Disorder

  2015cites this paper
• IMPORTANT BIOACTIVE PROPERTIES OF OMEGA-3 FATTY ACIDS

  2015cites this paper
• A narrative review of the efficacy of DHA for treatment of major depressive disorder and treatment and prevention of postnatal depression

  2015cites this paper
• Polyunsaturated Fatty Acids in Adult Psychiatric Disorders: A Comprehensive Overview

  2015cites this paper
• Immunology and Psychiatry

  2015cites this paper
• Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats

  2015cites this paper
• Associations of the Ratios of n-3 to n-6 Dietary Fatty Acids With Longitudinal Changes in Depressive Symptoms Among US Women.

  2015cites this paper
• Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses.

  2014cites this paper
• Quantification of intracellular and extracellular eicosapentaenoic acid-derived 3-series prostanoids by liquid chromatography/electrospray ionization tandem mass spectrometry.

  2014cites this paper
• Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials

  2014cites this paper
• Low plasma eicosapentaenoic acid levels are associated with elevated trait aggression and impulsivity in major depressive disorder with a history of comorbid substance use disorder.

  2014cites this paper
• Omega-3 fatty acids: physiology, biological sources and potential applications in supportive cancer care

  2013cites this paper
• The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial.

  2013cites this paper
• Improvement of Major Depression is Associated with Increased Erythrocyte DHA

  2013cites this paper