Antioxidant Nanomedicine Protects against Ionizing Radiation-Induced Life-Shortening in C57BL/6J Mice.

This study examined a new redox nanoparticle (RNPN) for its ability to protect mice from the life-shortening effect of radiation. A single dose of RNPN was injected subcutaneously into mice 3 or 24 h before whole-body irradiation. Kaplan-Meier survival analysis showed that RNPN given 24 h before whole-body irradiation protected mice against radiation-induced mortality. Histological evaluation of the bone marrow showed that the probable cause of sporadic deaths was bone marrow aplasia. Furthermore, analysis of blood biomarkers revealed abnormalities in the irradiated control group. Such symptoms/indicators of poor health were reduced in RNPN-treated mice.

• Publication year

  2019

• Venue

  ACS Biomaterials Science & Engineering

• Publication date

  2019-01-16

• Fields of study

  Medicine, Materials Science, Environmental Science

• Identifiers
  DOI 10.1021/ACSBIOMATERIALS.8B01259PMID 33405693
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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