Role of the proteasome complex in degradation of human CYP2E1 in transfected HepG2 cells.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  1996-09-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1006/BBRC.1996.1418PMID 8831679
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ethanol Induces CYP2E1 by Protein Stabilization

  1995cited by this paper
• Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells.

  1995cited by this paper
• Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line.

  1995cited by this paper
• Rabbit P450 2E1 expressed in CHO-K1 cells has a short half-life.

  1995cited by this paper
• Ethanol increases content and activity of human cytochrome P4502E1 in a transduced HepG2 cell line.

  1994cited by this paper
• Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates.

  1993cited by this paper
• Changes in microsomal phospholipases and arachidonic acid in experimental alcoholic liver injury: relationship to cytochrome P-450 2E1 induction and conjugated diene formation.

  1993cited by this paper
• Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis.

  1993cited by this paper
• Degradation of cytochrome P450 2E1: selective loss after labilization of the enzyme.

  1992cited by this paper
• Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes.

  1992cited by this paper
• Oxidative and reductive metabolism by cytochrome P450 2E1

  1992cited by this paper
• Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells.

  1992cited by this paper
• Implication of free radical mechanisms in ethanol-induced cellular injury.

  1992cited by this paper
• Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.

  1991cited by this paper
• Post-translational reduction of cytochrome P450IIE by CCl4, its substrate.

  1991cited by this paper
• Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes.

  1991cited by this paper
• Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation.

  1990cited by this paper
• The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

  1990cited by this paper
• Multiple mechanisms in the regulation of ethanol‐inducible cytochrome P450IIE1

  1990cited by this paper
• Substrate-, hormone-, and cAMP-regulated cytochrome P450 degradation.

  1990cited by this paper
• Rapid decrease of cytochrome P‐450IIE1 in primary hepatocyte culture and its maintenance by added 4‐methylpyrazole

  1990cited by this paper
• Induction of rat hepatic P450IIE1 (CYP 2E1) by pyridine: evidence for a role of protein synthesis in the absence of transcriptional activation.

  1990cited by this paper
• Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1).

  1989cited by this paper
• Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization.

  1989cited by this paper
• ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

  1989cited by this paper
• Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures.

  1988cited by this paper
• Organization and differential expression of two highly similar genes in the rabbit alcohol-inducible cytochrome P-450 subfamily.

  1988cited by this paper
• Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat.

  1987cited by this paper
• Purification of two high molecular weight proteases from rabbit reticulocyte lysate.

  1987cited by this paper
• Ubiquitin-mediated pathways for intracellular proteolysis.

  1987cited by this paper
• Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

  1986cited by this paper
• Ethanol oxidation and toxicity: role of alcohol P-450 oxygenase.

  1986cited by this paper

• Microsomal Ethanol‐Oxidizing System: Success Over 50 Years and an Encouraging Future

  2019cites this paper
• The importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome.

  2013cites this paper
• Cellular proteolytic systems in P450 degradation: evolutionary conservation from Saccharomyces cerevisiae to mammalian liver

  2007cites this paper
• Enhancement by pyrazole of lipopolysaccharide‐induced liver injury in mice: Role of cytochrome P450 2E1 and 2A5

  2006cites this paper
• Cytochrome P450 ubiquitination: branding for the proteolytic slaughter?

  2005cites this paper
• Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for the Degradation of Mammalian Endoplasmic Reticulum P450 Proteins

  2005cites this paper
• Proteolytic Degradation of Nitric Oxide Synthase: Effect of Inhibitors and Role of hsp90-Based Chaperones

  2003cites this paper
• Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells

  2003cites this paper
• Induction of CYP3A by ethanol in multiple in vitro and in vivo models.

  2003cites this paper
• Hepatic Cytochrome P450 Degradation: Mechanistic Diversity of the Cellular Sanitation Brigade

  2003influential citation
• Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341.

  2002cites this paper
• The paradoxical effect of acetaminophen on CYP3A4 activity and content in transfected HepG2 cells.

  2002cites this paper
• Differential effects of oltipraz on CYP1A and CYP2B in rat lung.

  2001cites this paper
• CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90.

  2000cites this paper
• Stabilization of cytochrome P4502E1 protein by ethanol in primary hamster hepatocyte cultures.

  2000cites this paper
• Effects of chronic ethanol administration on rat liver proteasome activities: Relationship with oxidative stress

  1999cites this paper
• NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species.

  1999cites this paper
• Cytochrome P450 3A degradation in isolated rat hepatocytes: 26S proteasome inhibitors as probes.

  1999cites this paper
• Peptidase activities of the multicatalytic protease in rat liver after voluntary and intragastric ethanol administration

  1998cites this paper
• Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1.

  1997cites this paper
• Protein phosphorylation changes ligand-binding efficiency of cytochrome P450c17 (CYP17) and accelerates its proteolytic degradation: putative relevance for hormonal regulation of CYP17 activity.

  1997cites this paper
• Selective fast degradation of cytochrome P-450 2E1 in serum-deprived hepatoma cells by a mechanism sensitive to inhibitors of vesicular transport.

  1997cites this paper