Energetics by NMR: Site-specific binding in a positively cooperative system

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2002-02-19

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.012379199PMID 11854486PMCID PMC122282
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of the Bile Acid-binding Site of the Ileal Lipid-binding Protein by Photoaffinity Labeling, Matrix-assisted Laser Desorption Ionization-Mass Spectrometry, and NMR Structure*

  2001cited by this paper
• Identification of a Ligand-binding Site in the Na+/Bile Acid Cotransporting Protein from Rabbit Ileum*

  2001cited by this paper
• Confirmation of a unique intra‐dimer cooperativity in the human hemoglobin α1β1half‐oxygenated intermediate supports the symmetry rule model of allosteric regulation

  2000cited by this paper
• Solution structure of ileal lipid binding protein in complex with glycocholate.

  2000cited by this paper
• Confirmation of a unique intra-dimer cooperativity in the human hemoglobin alpha(1)beta(1)half-oxygenated intermediate supports the symmetry rule model of allosteric regulation.

  2000cited by this paper
• Deciphering the molecular code of hemoglobin allostery.

  1998cited by this paper
• Intestinal absorption of bile acids: paradoxical behaviour of the 14 kDa ileal lipid-binding protein in differential photoaffinity labelling.

  1998cited by this paper
• Thermodynamic Theory of Site-Specific Binding Processes in Biological Macromolecules

  1996influential reference
• Apoptosis and gastrointestinal pharmacology.

  1996cited by this paper
• Reduced bile acid-induced apoptosis in "normal" colorectal mucosa: a potential biological marker for cancer risk.

  1996cited by this paper
• Cellular fatty acid-binding proteins: their function and physiological significance.

  1996cited by this paper
• Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques

  1994cited by this paper
• Molecular code for cooperativity in hemoglobin.

  1992cited by this paper
• Three-dimensional triple-resonance NMR of 13C/15N-enriched proteins using constant-time evolution

  1991cited by this paper
• Developmental and structural studies of an intracellular lipid binding protein expressed in the ileal epithelium.

  1990cited by this paper
• Identification of cytosolic and microsomal bile acid-binding proteins in rat ileal enterocytes.

  1990cited by this paper
• Rapid measurement of binding constants and heats of binding using a new titration calorimeter.

  1989cited by this paper
• Free energy coupling within macromolecules. The chemical work of ligand binding at the individual sites in co-operative systems.

  1983cited by this paper
• An improved procedure for the synthesis of glycine and taurine conjugates of bile acids.

  1977cited by this paper
• Allosteric proteins and cellular control systems.

  1963cited by this paper

• Determinants of site-selectivity in human ileal bile acid-binding protein by NMR dynamic analysis of a functionally-impaired mutant.

  2025cites this paper
• Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures (NECEEM)-Enabled Mechanistic Analysis of Cooperative Binding: Application to C-Reactive Protein-SOMAmer Complexes.

  2025cites this paper
• Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein

  2022cites this paper
• Structural and Dynamic Determinants of Molecular Recognition in Bile Acid-Binding Proteins

  2022cites this paper
• Design and recognition of cucurbituril-secured platinum-bound oligopeptides†

  2021cites this paper
• Allostery: Methods and Protocols

  2021cites this paper
• Cooperativity and Allostery in RNA Systems.

  2020cites this paper
• Intestinal Absorption of Bile Acids in Health and Disease.

  2019cites this paper
• Thermodynamic versus Kinetic Discrimination of Cooperativity of Enzymatic Ligand Binding

  2019cites this paper
• Different modes of barrel opening suggest a complex pathway of ligand binding in human gastrotropin

  2019cites this paper
• Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation

  2019cites this paper
• Tritopic ion-pair receptors based on anion-π interactions for selective CaX2 binding.

  2018cites this paper
• Achieving Strong Positive Cooperativity through Activating Weak Non-Covalent Interactions.

  2018cites this paper
• The ligand-mediated affinity of escort proteins determines the directionality of lipophilic cargo transport

  2018cites this paper
• Structural ensembles based on NMR parameters suggest a complex pathway of ligand binding in human gastrotropin

  2018cites this paper
• Thermodynamics in Drug Discovery

  2017cites this paper
• Structural insight into a partially unfolded state preceding aggregation in an intracellular lipid‐binding protein

  2017cites this paper
• The long variant of human ileal bile acid-binding protein associated with colorectal cancer exhibits sub-cellular localization and lipid binding behaviour distinct from those of the common isoform.

  2017cites this paper
• Probing subunit communication via a singly ligated state of dimeric thymidylate synthase

  2017cites this paper
• Molecular differences between human liver fatty acid binding protein and its T94A variant in their unbound and lipid-bound states.

  2017cites this paper
• Bile Acid Recognition by Mouse Ileal Bile Acid Binding Protein.

  2017cites this paper
• Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR

  2016cites this paper
• Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6).

  2016cites this paper
• Synaptotagmin I's Intrinsically Disordered Region Interacts with Synaptic Vesicle Lipids and Exerts Allosteric Control over C2A.

  2016cites this paper
• Global ITC fitting methods in studies of protein allostery.

  2015cites this paper
• The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90

  2015cites this paper
• Bile salt recognition by human liver fatty acid binding protein

  2015cites this paper
• All-Purpose Containers? Lipid-Binding Protein – Drug Interactions

  2015cites this paper
• Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity.

  2015cites this paper
• The unique ligand binding features of subfamily-II iLBPs with respect to bile salts and related drugs.

  2015cites this paper
• Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS

  2015cites this paper
• Sequential inclusion of two berberine cations in cucurbit[8]uril cavity: kinetic and thermodynamic studies.

  2014cites this paper
• Characterization of the covalent binding of allyl isothiocyanate to β-lactoglobulin by fluorescence quenching, equilibrium measurement, and mass spectrometry

  2014cites this paper
• Temperature dependence of backbone dynamics in human ileal bile acid-binding protein: implications for the mechanism of ligand binding.

  2014cites this paper
• Analyzing protein-ligand interactions by dynamic NMR spectroscopy.

  2013cites this paper
• Measuring Positive Cooperativity Using the Direct ESI-MS Assay. Cholera Toxin B Subunit Homopentamer Binding to GM1 Pentasaccharide

  2013cites this paper
• Ligand Binding Promiscuity of Human Liver Fatty Acid Binding Protein: Structural and Dynamic Insights from an Interaction Study with Glycocholate and Oleate

  2013cites this paper
• Bile acid binding protein: a versatile host of small hydrophobic ligands for applications in the fields of MRI contrast agents and bio-nanomaterials

  2013cites this paper
• Recombinant proteins incorporating short non-native extensions may display increased aggregation propensity as detected by high resolution NMR spectroscopy.

  2012cites this paper
• Van't Hoff global analyses of variable temperature isothermal titration calorimetry data.

  2012cites this paper
• NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism

  2012cites this paper
• A disulfide bridge allows for site-selective binding in liver bile acid binding protein thereby stabilising the orientation of key amino acid side chains.

  2012cites this paper
• Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα[S]

  2012cites this paper
• Characterization of the 1st and 2nd EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism

  2012cites this paper
• Internal motions and exchange processes in human ileal bile acid binding protein as studied by backbone (15)N nuclear magnetic resonance spectroscopy.

  2012cites this paper
• Structural Requirements for Cooperativity in Ileal Bile Acid-binding Proteins*

  2011cites this paper
• Site‐Specific Free Energy Changes in Proteins upon Ligand Binding by Nuclear Magnetic Resonance: Ca2+‐Displacement by Ln3+ in a Ca2+‐Binding Protein from Entamoeba histolytica

  2011cites this paper
• ANuclearMagnetic Resonance-Based Structural Rationale for Contrasting Stoichiometry and Ligand Binding Site ( s ) in Fatty Acid-Binding Proteins †

  2011cites this paper
• Thermodynamics of Ligand-Protein Interactions: Implications for Molecular Design

  2011cites this paper
• A nuclear magnetic resonance-based structural rationale for contrasting stoichiometry and ligand binding site(s) in fatty acid-binding proteins.

  2011cites this paper
• Liver bile acid intracellular transporter: NMR studies of unfolding, cooperative binding and interaction with membrane mimetic.

  2010cites this paper
• Inhibiting the Initiation of Clostridium difficile Spore Germination using Analogs of Chenodeoxycholic Acid, a Bile Acid

  2010cites this paper
• Deconstructing thermodynamic parameters of a coupled system from site-specific observables

  2010cites this paper
• Site-specific investigation of the steady-state kinetics and dynamics of the multistep binding of bile acid molecules to a lipid carrier protein.

  2010cites this paper
• Chicken ileal bile-acid-binding protein: a promising target of investigation to understand binding co-operativity across the protein family.

  2010cites this paper
• Coarse-grained models of biomolecule dynamics and allostery

  2010cites this paper
• Isothermal titration calorimetry: general formalism using binding polynomials.

  2009cites this paper
• Comparison of the folding mechanism of highly homologous proteins in the lipid‐binding protein family

  2009cites this paper
• The X-ray structure of zebrafish (Danio rerio) ileal bile acid-binding protein reveals the presence of binding sites on the surface of the protein molecule.

  2009cites this paper
• Mechanism of ligand-induced folding of a natively unfolded helixless variant of rabbit I-BABP.

  2009cites this paper
• NMR studies reveal the role of biomembranes in modulating ligand binding and release by intracellular bile acid binding proteins.

  2009cites this paper
• Analysis of Cooperativity by Isothermal Titration Calorimetry

  2009influential citation
• Towards the elucidation of molecular determinants of cooperativity in the liver bile acid binding protein

  2009cites this paper
• Effects of the number and placement of positive charges on viologen–cucurbit[n]uril interactions

  2008cites this paper
• The second transmembrane domain of the large conductance, voltage‐ and calcium‐gated potassium channel β 1 subunit is a lithocholate sensor

  2008cites this paper
• Design, synthesis, and evaluation of an isotopic labeling strategy for studying fatty acid-protein binding by NMR.

  2008cites this paper
• A Single Amino Acid Mutation in Zebrafish (Danio rerio) Liver Bile Acid-binding Protein Can Change the Stoichiometry of Ligand Binding*

  2007cites this paper
• NMR structural studies of the supramolecular adducts between a liver cytosolic bile acid binding protein and gadolinium(III)-chelates bearing bile acids residues: molecular determinants of the binding of a hepatospecific magnetic resonance imaging contrast agent.

  2007cites this paper
• Bile acid interactions with rabbit ileal lipid binding protein and an engineered helixless variant reveal novel ligand binding properties of a versatile beta-clam shell protein scaffold.

  2007cites this paper
• Kinetic mechanism of ligand binding in human ileal bile acid binding protein as determined by stopped-flow fluorescence analysis.

  2007cites this paper
• Identification and functional characterization of the bile acid transport proteins in non‐mammalian ileum and mammalian liver

  2007cites this paper
• Survey of the year 2005: literature on applications of isothermal titration calorimetry

  2007cites this paper
• Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications

  2007cites this paper
• NMR‐based modeling and binding studies of a ternary complex between chicken liver bile acid binding protein and bile acids

  2007cites this paper
• Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: Application to adaptor protein complexes in cell signaling

  2007cites this paper
• Dynamic allostery in the ring protein TRAP.

  2007cites this paper
• Advances in the analysis of isothermal titration calorimetry data for ligand-DNA interactions.

  2007cites this paper
• Structural and dynamic determinants of ligand binding in the ternary complex of chicken liver bile acid binding protein with two bile salts revealed by NMR.

  2007cites this paper
• NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

  2006cites this paper
• Sequence-specific recognition and cooperative dimerization of N-terminal aromatic peptides in aqueous solution by a synthetic host.

  2006cites this paper
• Coupling ligand recognition to protein folding in an engineered variant of rabbit ileal lipid binding protein.

  2006cites this paper
• Molecular Mechanism of Membrane Docking by the Vam7p PX Domain*

  2006cites this paper
• Intrinsic Inhibition of the Hsp90 ATPase Activity*

  2006cites this paper
• Crystal structure of axolotl (Ambystoma mexicanum) liver bile acid‐binding protein bound to cholic and oleic acid

  2006cites this paper
• NMR Dynamic Studies Suggest that Allosteric Activation Regulates Ligand Binding in Chicken Liver Bile Acid-binding Protein*

  2006cites this paper
• Determinants of cooperativity and site selectivity in human ileal bile acid binding protein.

  2006cites this paper
• Crystal structure of chicken liver basic fatty acid-binding protein complexed with cholic acid.

  2004cites this paper
• Tracing kinetic intermediates during ligand binding.

  2004cites this paper
• Multivalent Mechanism of Membrane Insertion by the FYVE Domain*

  2004cites this paper
• A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein.

  2004cites this paper
• A survey of the year 2002 literature on applications of isothermal titration calorimetry.

  2003cites this paper
• Fluorescent dyes as probes to study lipid‐binding proteins

  2003influential citation
• Water dynamics in the large cavity of three lipid-binding proteins monitored by (17)O magnetic relaxation dispersion.

  2003cites this paper
• Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein.

  2003cites this paper
• New insights into intracellular lipid binding proteins: The role of buried water

  2002cites this paper