Human genetic variation is associated with Plasmodium falciparum drug resistance.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Infectious Diseases

• Publication date

  2011-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/infdis/jir629PMID 21998472
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.

  2013cited by this paper
• History and current status of Plasmodium falciparum antimalarial drug resistance in Madagascar

  2010cited by this paper
• Chloroquine Clinical Failures in P. falciparum Malaria Are Associated with Mutant Pfmdr-1, Not Pfcrt in Madagascar

  2010cited by this paper
• Genetic variation in human HBB is associated with Plasmodium falciparum transmission

  2010cited by this paper
• Pharmacogenetics of antimalarial drugs: effect on metabolism and transport.

  2009cited by this paper
• Application of pharmacogenomics to malaria: a holistic approach for successful chemotherapy.

  2009cited by this paper
• HLA-DRB1 and -DQB1 loci in three west African ethnic groups: genetic relationship with sub-Saharan African and European populations.

  2009cited by this paper
• Discordant Patterns of Genetic Variation at Two Chloroquine Resistance Loci in Worldwide Populations of the Malaria Parasite Plasmodium falciparum

  2008cited by this paper
• Clinically immune hosts as a refuge for drug-sensitive malaria parasites

  2008cited by this paper
• Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria

  2008cited by this paper
• Dispersal estimation: Demystifying Moran's I

  2008cited by this paper
• Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

  2008cited by this paper
• Amodiaquine Metabolism is Impaired by Common Polymorphisms in CYP2C8: Implications for Malaria Treatment in Africa

  2007cited by this paper
• Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.

  2007cited by this paper
• Pharmacogenetics of cytochromes P450 in tropical medicine.

  2006cited by this paper
• Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites.

  2006cited by this paper
• CYP2C8 polymorphism frequencies among malaria patients in Zanzibar

  2005cited by this paper
• Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles.

  2005influential reference
• Cytochrome P450 2C8: Substrates, Inhibitors, Pharmacogenetics, and Clinical Relevance

  2005influential reference
• pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.

  2005cited by this paper
• How malaria has affected the human genome and what human genetics can teach us about malaria.

  2005cited by this paper
• Short communication: High prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana

  2005cited by this paper
• Different antibody- and cytokine-mediated responses to Plasmodium falciparum parasite in two sympatric ethnic tribes living in Mali.

  2005cited by this paper
• Chloroquine blood concentrations and molecular markers of chloroquine-resistant Plasmodium falciparum in febrile children in northern Ghana.

  2003cited by this paper
• Identification of human cytochrome P450s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data

  2003cited by this paper
• In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

  2003influential reference
• Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria.

  2003cited by this paper
• Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes

  2003influential reference
• The evolution of drug-resistant malaria: the role of drug elimination half-life.

  2002cited by this paper
• Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

  2002cited by this paper
• HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations.

  2001cited by this paper
• Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

  2001cited by this paper
• A molecular marker for chloroquine-resistant falciparum malaria.

  2001cited by this paper
• Plasmodium falciparum: linkage disequilibrium between loci in chromosomes 7 and 5 and chloroquine selective pressure in Northern Nigeria

  2001influential reference
• The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (west Africa) is associated with low frequencies of classic malaria-resistance genes.

  2001cited by this paper
• A molecular marker for chloroquine-resistant falciparum malaria.

  2001cited by this paper
• Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

  2000cited by this paper
• The disposition of chloroquine and its main metabolite desethylchloroquine in volunteers with and without chloroquine‐induced pruritus: Evidence for decreased chloroquine metabolism in volunteers with pruritus

  2000cited by this paper
• More on 'the efficacy of antifolate antimalarial combinations in Africa'.

  1999cited by this paper
• Interethnic differences in the humoral response to non-repetitive regions of the Plasmodium falciparum circumsporozoite protein.

  1999cited by this paper
• Baseline immunity of the population and impact of insecticide-treated curtains on malaria infection.

  1998cited by this paper
• Pharmacokinetics of Quinine, Chloroquine and Amodiaquine

  1996cited by this paper
• Different response to Plasmodium falciparum malaria in west African sympatric ethnic groups.

  1996cited by this paper
• Plasmodium falciparum malaria in sympatric ethnic groups of Burkina Faso, west Africa.

  1995cited by this paper
• Antimalarial 4‐aminoquinolines: mode of action and pharmacokinetics

  1994cited by this paper
• Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

  1994cited by this paper
• Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: selective pressure for resistance is a function of long elimination half-life.

  1993cited by this paper
• A national survey of the prevalence of chloroquine resistant Plasmodium falciparum in Burkina Faso.

  1993influential reference
• Amplification of the multidrug resistance gene pfmdr1 in Plasmodium falciparum has arisen as multiple independent events

  1991cited by this paper
• Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

  1990cited by this paper
• Determination of chloroquine and its metabolites in urine: a field method based on ion-pair extraction.

  1985cited by this paper

• Decoding Allosteric Effects of Missense Variations in Drug Metabolism: Afrocentric CYP3A4 Alleles Explored.

  2025cites this paper
• Investigating Pfk13 mutations in Plasmodium falciparum natural populations from two malaria-endemic areas of Cameroon.

  2025cites this paper
• Pediatric pharmacogenetics: profiling CYP2C8 polymorphisms at King Abdulaziz University Dental Clinic

  2024cites this paper
• Genetic polymorphisms of CYP2B6*6, CYP2C8*3 and CYP2D6*4 in vivax malaria patients from Brazilian Amazon

  2023cites this paper
• Pharmacogenetics of Breast Cancer Treatments: A Sub-Saharan Africa Perspective

  2022cites this paper
• Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.

  2022cites this paper
• PGPM_A_308531 613..652

  2022cites this paper
• An update on pharmacogenetic factors influencing the metabolism and toxicity of artemisinin-based combination therapy in the treatment of malaria

  2022cites this paper
• Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment

  2021cites this paper
• Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana

  2021cites this paper
• Profiling of warfarin pharmacokinetics‐associated genetic variants: Black Africans portray unique genetic markers important for an African specific warfarin pharmacogenetics‐dosing algorithm

  2021cites this paper
• Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria.

  2020cites this paper
• Oral Manifestations of Nutritional Deficiencies: Single Centre Analysis.

  2020cites this paper
• Influence of CYP2C8, CYP3A4, and CYP3A5 Host Genotypes on Early Recurrence of Plasmodium vivax

  2020cites this paper
• Distribution of the cytochrome P450 CYP2C8*2 allele in Brazzaville, Republic of Congo.

  2019cites this paper
• Characterization of drug resistance and genetic diversity of Plasmodium falciparum parasites from Tripura, Northeast India

  2019cites this paper
• Exploring Human Genetic Variation – Scientific and Ethical Challenges

  2018cites this paper
• Molecular detection of human papillomavirus (HPV) in highly fragmented DNA from cervical cancer biopsies using double-nested PCR

  2018cites this paper
• Human genetic susceptibility to Chagas disease

  2017cites this paper
• Current Progress in the Pharmacogenetics of Infectious Disease Therapy

  2017cites this paper
• Polymorphisms in CYP2C8 and CYP3A5 genes in the Nigerian population.

  2017cites this paper
• Disease burden and the role of pharmacogenomics in African populations

  2017cites this paper
• Pharmacogenomics for infectious diseases in sub-Saharan Africa: Successes and opportunities

  2016cites this paper
• Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses

  2016cites this paper
• Cytochrome P450 2C8*2 allele in Botswana: Human genetic diversity and public health implications.

  2016cites this paper
• Drug-resistant tuberculosis viewed from bacterial and host genomes.

  2016cites this paper
• Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

  2016influential citation
• Prevalence of the genetic mutation Cyp2c8*5 in selected ethnic groups in Southern Ghana

  2016cites this paper
• Implications of Pharmacogenetics for Antimicrobial Prescribing

  2016cites this paper
• Impact of genetic variations in C-C chemokine receptors and ligands on infectious diseases.

  2016cites this paper
• Chemokine genetic polymorphism in human health and disease.

  2016cites this paper
• Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition

  2015cites this paper
• Priority pharmacogenetics for the African continent : Focus on Cytochrome P 450

  2015cites this paper
• Mario Coluzzi (1938–2012)

  2014cites this paper
• Absence of the human CYP2C8*3 allele in Ugandan children exposed to Plasmodium falciparum malaria.

  2014cites this paper
• Priority pharmacogenetics for the African continent: focus on CYP450.

  2014cites this paper
• Absence of the human CYP 2 C 8 * 3 allele in Ugandan children exposed to Plasmodium falciparum malaria

  2014cites this paper
• Host genetics and parasitic infections.

  2014cites this paper
• Pharmacogenomics of antimicrobial agents.

  2014cites this paper
• Influence of CYP2C8*2 on the Pharmacokinetics of Pioglitazone in Healthy African‐American Volunteers

  2013cites this paper
• CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 alleles after amodiaquine-artesunate treatment.

  2013influential citation
• Cytochrome P450 pharmacogenetics in African populations

  2013cites this paper
• Prevalence of CYP2C8 polymorphisms in a North Indian population.

  2013cites this paper
• Reply to Cavaco et al.

  2013cites this paper
• Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria

  2013cites this paper
• Prevalence of CYP 2 C 8 polymorphisms in a North Indian population

  2013cites this paper
• Stem cell-derived cell cultures and organoids for protozoan parasite propagation and studying host-parasite interaction.

  2012cites this paper
• PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 8

  2012cites this paper
• The role of molecular markers in emerging artemether-lumefantrine resistant Plasmodium falciparum

  2012cites this paper
• Distribution of human CYP2C8*2 allele in three different African populations

  2012influential citation
• Can we teach an old drug new tricks?

  2012cites this paper