Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in Mice

Trachyspermum ammi (T. ammi ) has been used in folk medicine as anti-inflammatory, antipyretic, antibacterial, antifungal agent. The present study was conducted to investigate the protective effect of Tra hyspermum ammi (T. ammi ) essential oil against CC1 4induced nephrotoxicity in mice. Thirty-five mice were divided into five groups as follows; positive control received olive oil 1 mL/ kg/ip, negative control received CC1 4 1 mg/kg/ip + 0.5 mL distilled water orally and tree treatment groups which received CC1 4 similar to the negative control and 200, 800 and 1600 μg/kg of T. ammi essential oil, respectively. All treatments were done twice a week (Saturday and Wednesday) for 45 days. On the last day, blood was sampled for urea and creatinine assessment and the left kidney was remov d for stereological estimations. Essential oil of T. ammi at high dose significantly (p ≤ 0.05) decreased serum levels of creatinine and urea in comparison with CC1 4 -treated group. Total volume of the kidney, cortex, proximal convoluted tubules (PC), glomerulus, vessels and interstitial tissue as well as total length of PC and vessel were significantly (p ≤ 0.05) increased following CC1 4 administration and were restored toward normal levels at high dose of T. ammi . Also, high dose of T. ammi improved glomerular loss significantly (p ≤ 0.05) as compared with CC1 4 -treated group. Due to the chemical composition of T. ammi essential oil such as tymol, p-cymene, γ-terpinene which are antioxidant, it can be concluded that the essential oil of T. ammi can ameliorated renal injury induced following CC1 4 toxicity via its antioxidant components.

• Publication year

  2018

• Venue

  International Journal of Morphology

• Publication date

  2018-01-06

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.4067/S0717-95022018000200750
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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