CHAPTER 5 – Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Protein: Signaling and Regulation

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• Publication year

  2001

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  Unknown venue

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  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/B978-012098651-4/50007-9
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  Open on Semantic Scholar

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  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Uncovering molecular mechanisms involved in activation of G protein-coupled receptors.

  2000cited by this paper
• Receptors for parathyroid hormone and parathyroid hormone-related peptide: exploration of their biological importance.

  1999cited by this paper
• A novel parathyroid hormone (PTH)/PTH-related peptide receptor mutation in Jansen's metaphyseal chondrodysplasia.

  1999cited by this paper
• The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm.

  1999cited by this paper
• Structural basis of G protein-coupled receptor function.

  1999cited by this paper
• Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy.

  1999cited by this paper
• Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases.

  1999cited by this paper
• G‐protein coupled receptor kinases as modulators of G‐protein signalling

  1999cited by this paper
• Clinical implications of genetic defects in G proteins: oncogenic mutations in G alpha s as the molecular basis for the McCune-Albright syndrome.

  1999cited by this paper
• Receptors for PTH and PTHrP: their biological importance and functional properties.

  1999cited by this paper
• A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia.

  1998cited by this paper
• Regulation of the transcription of parathyroid-hormone/parathyroid-hormone-related peptide receptor mRNA by dexamethasone in ROS 17/2.8 osteosarcoma cells.

  1998cited by this paper
• Agonist-dependent phosphorylation of the parathyroid hormone/parathyroid hormone-related peptide receptor.

  1998cited by this paper
• The G-Protein ? Complex

  1998cited by this paper
• Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia.

  1998cited by this paper
• The role of receptor kinases and arrestins in G protein-coupled receptor regulation.

  1998cited by this paper
• Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia.

  1998cited by this paper
• Evidence for interference of vitamin D with PTH/PTHrP receptor expression in opossum kidney cells

  1998cited by this paper
• G protein-coupled receptor kinases.

  1998cited by this paper
• Editorial: Parathyroid Hormone (PTH)/PTHrP Receptor Mutations in Human Chondrodysplasia.

  1998cited by this paper
• Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs*

  1998cited by this paper
• G Protein-coupled Receptors

  1998cited by this paper
• Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization.

  1998cited by this paper
• Mutations in the Second Cytoplasmic Loop of the Rat Parathyroid Hormone (PTH)/PTH-related Protein Receptor Result in Selective Loss of PTH-stimulated Phospholipase C Activity*

  1997cited by this paper
• Beta-adrenergic receptor kinase-1 acutely regulates PTH/PTHrP receptor signalling in human osteoblastlike cells.

  1997cited by this paper
• A new family of G-protein regulators - the RGS proteins.

  1997cited by this paper
• Visualizing signal transduction: receptors, G-proteins, and adenylate cyclases.

  1996cited by this paper
• Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia.

  1996cited by this paper
• β‐Adrenergic receptor kinase‐like activity and β‐arrestin are expressed in osteoblastic cells

  1996cited by this paper
• Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F

  1996cited by this paper
• β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

  1996cited by this paper
• The N-terminal Region of the Third Intracellular Loop of the Parathyroid Hormone (PTH)/PTH-related Peptide Receptor Is Critical for Coupling to cAMP and Inositol Phosphate/Ca2+ Signal Transduction Pathways*

  1996cited by this paper
• Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors.

  1996cited by this paper
• Receptors for VIP, PACAP, Secretin, GRF, Glucagon, GLP‐1, and Other Members of Their New Family of G Protein‐Linked Receptors: Structure‐Function Relationship with Special Reference to the Human VIP‐1 Receptor a

  1996cited by this paper
• Conformational characterization of a peptide mimetic of the third cytoplasmic loop of the G‐protein coupled parathyroid hormone/parathyroid hormone related protein receptor

  1996cited by this paper
• Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

  1996cited by this paper
• Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor.

  1996cited by this paper
• Transmembrane Residues of the Parathyroid Hormone (PTH)/PTH-related Peptide Receptor That Specifically Affect Binding and Signaling by Agonist Ligands*

  1996cited by this paper
• Down‐regulation of the receptor for parathyroid hormone (PTH) and PTH‐related peptide by PTH in primary fetal rat osteoblasts

  1996cited by this paper
• Phosphorylation of the cytoplasmic tail of the PTH/PTHrP receptor

  1996cited by this paper
• Coordinate regulation of PTH/PTHrP receptors by PTH and calcitriol in UMR 106-01 osteoblast-like cells.

  1996cited by this paper
• The family of G‐protein‐coupled receptors

  1995cited by this paper
• Parathyroidectomy does not prevent the renal PTH/PTHrP receptor down-regulation in uremic rats.

  1995cited by this paper
• Truncation of the Carboxyl-terminal Region of the Rat Parathyroid Hormone (PTH)/PTH-related Peptide Receptor Enhances PTH Stimulation of Adenylyl Cyclase but Not Phospholipase C (*)

  1995cited by this paper
• Down-regulation of the receptor for parathyroid hormone (PTH) and PTH-related peptide by transforming growth factor-beta in primary fetal rat osteoblasts.

  1995cited by this paper
• A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia.

  1995cited by this paper
• Interaction of tyrosine-based sorting signals with clathrin-associated proteins.

  1995cited by this paper
• The Cytoplasmic Tail of the G-protein-coupled Receptor for Parathyroid Hormone and Parathyroid Hormone-related Protein Contains Positive and Negative Signals for Endocytosis (*)

  1995cited by this paper
• Parathyroid hormone (PTH)/PTH-related protein receptor messenger ribonucleic acid expression and PTH response in a rat model of secondary hyperparathyroidism associated with vitamin D deficiency.

  1995cited by this paper
• Agonist-stimulated phosphorylation of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein.

  1995cited by this paper
• Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling.

  1995cited by this paper
• Transforming growth factor-beta1 regulates steady-state PTH/PTHrP receptor mRNA levels and PTHrP binding in ROS 17/2.8 osteosarcoma cells.

  1994cited by this paper
• Transforming growth factor-beta: a down-regulator of the parathyroid hormone-related protein receptor in renal epithelial cells.

  1994cited by this paper
• A C‐terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins

  1994cited by this paper
• Studies on the mechanism of desensitization of the parathyroid hormone‐stimulated calcium signal in UMR‐106 cells: Reversal of desensitization by alkaline phosphatase but not by protein kinase C downregulation

  1994cited by this paper
• Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells.

  1994cited by this paper
• Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2).

  1994cited by this paper
• Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family.

  1993cited by this paper
• Rhodopsin and phototransduction: a model system for G protein‐linked receptors

  1992cited by this paper
• Mechanisms of desensitization to parathyroid hormone in human osteoblast-like SaOS-2 cells.

  1992cited by this paper
• A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.

  1991cited by this paper
• Thrombin and parathyroid hormone mobilize intracellular calcium in rat osteosarcoma cells by distinct pathways.

  1991cited by this paper
• Turning off the signal: desensitization of β‐adrenergic receptor function

  1990cited by this paper
• beta-Arrestin: a protein that regulates beta-adrenergic receptor function.

  1990cited by this paper
• Mechanisms of homologous and heterologous regulation of parathyroid hormone receptors in the rat osteosarcoma cell line UMR-106.

  1990cited by this paper
• Desensitization of parathyroid hormone receptors on cultured bone cells

  1990cited by this paper
• Beta-adrenergic receptor kinase: primary structure delineates a multigene family.

  1989cited by this paper
• Characterization and agonist-induced down-regulation of parathyroid hormone receptors in clonal rat osteosarcoma cells.

  1988cited by this paper
• Down-regulation of parathyroid hormone (PTH) receptors in cultured bone cells is associated with agonist-specific intracellular processing of PTH-receptor complexes.

  1986cited by this paper
• The Jansen type of metaphyseal chondrodysplasia: confirmation of dominant inheritance and review of radiographic manifestations in the newborn and adult.

  1984cited by this paper
• Canine renal receptors for parathyroid hormone. Down-regulation in vivo by exogenous parathyroid hormone.

  1983cited by this paper
• Binding of radioiodinated bovine parathyroid hormone-(1-84) to canine renal cortical membranes.

  1983cited by this paper
• Homologous desensitization of cultured chick kidney cells to parathyroid hormone.

  1983cited by this paper
• Reversible resistance to the renal action of parathyroid hormone in human vitamin D deficiency.

  1982cited by this paper
• Parathyroid hormone receptor in intact embryonic chicken bone: characterization and cellular localization

  1982cited by this paper
• Coupling of the canine renal parathyroid hormone receptor to adenylate cyclase: modulation by guanyl nucleotides and N-ethylmaleimide.

  1982cited by this paper
• Rat kidney cells in primary culture: hormone-mediated desensitization of the adenosine 3',5'-monophosphate response to parathyroid hormone and calcitonin.

  1982cited by this paper
• Regulation of the PTH-receptor-cyclase system of canine kidney: effects of calcium, magnesium, and guanine nucleotides.

  1981cited by this paper
• Endogenous biologically active human parathyroid hormone: measurement by a guanyl nucleotide-amplified renal adenylate cyclase assay.

  1981cited by this paper
• Factors regulating the response of cells cultured from human giant cell tumors of bone to parathyroid hormone.

  1981cited by this paper
• Nephrogenous cyclic AMP as a parathyroid function test.

  1979cited by this paper
• Parathyroid hormone-mediated refractoriness of rat kidney cyclic AMP system.

  1979cited by this paper
• Induction of metabolic changes and down regulation of bovine parathyroid hormone-responsive adenylate cyclase are dissociable in isolated osteoclastic and osteoblastic bone cells.

  1979cited by this paper
• States of activation of chick kidney adenylate cyclase induced by parathyroid hormone and guanyl nucleotides.

  1977cited by this paper
• Human fat cell adenylate cyclase

  1977cited by this paper
• Skeletal resistance to the calcemic action of parathyroid hormone in uremia: role of 1,25 (OH)2 D3.

  1976cited by this paper
• Renal adenylate cyclase and the interrelationship between parathyroid hormone and vitamin D in the regulation of urinary phosphate and adenosine cyclic 3',5'-monophosphate excretion.

  1976cited by this paper
• Metaphyseal dysostosis of Jansen.

  1969cited by this paper

• Genetic regulation of parathyroid gland development

  2020cites this paper
• The Parathyroid and Disorders of Calcium and Bone Metabolism

  2019cites this paper
• Early parathyroid hormone laboratory abnormalities related to therapeutic radiation of neck: an Egyptian experience

  2015cites this paper
• Physiology of Calcium, Phosphate, Magnesium and Vitamin D.

  2015cites this paper
• A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.

  2014cites this paper
• Chapter 16. The Parathyroid and Disorders of Calcium and Bone Metabolism

  2010cites this paper
• Parathyroid hormone stimulates endothelial expression of atherosclerotic parameters through protein kinase pathways.

  2007cites this paper
• Parathyroid hormone‐related protein (PTHrP) inhibits mitochondrial‐dependent apoptosis through CK2

  2007cites this paper
• Parathyroid hormone related protein (PTHrP) inhibits TNFα‐induced apoptosis by blocking the extrinsic and intrinsic pathways

  2007cites this paper
• Parathyroid hormone stimulates the endothelial nitric oxide synthase through protein kinase A and C pathways.

  2007cites this paper
• Response to continuous and pulsatile PTH dosing: a mathematical model for parathyroid hormone receptor kinetics.

  2005cites this paper
• The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit.

  2005cites this paper
• Continuous PTH and PTHrP Infusion Causes Suppression of Bone Formation and Discordant Effects on 1,25(OH)2Vitamin D

  2005cites this paper
• Parathyroid responsiveness to hypocalcemic and hypercalcemic stimuli in adult growth hormone deficiency after growth hormone replacement.

  2004cites this paper
• Targeting the Osteoblast for Prevention and Treatment of Bone Diseases

  2004cites this paper
• Systemic and Local Regulators of Bone Remodeling

  2004cites this paper
• Parathyroid hormone-related protein and lung biology.

  2004cites this paper
• Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis.

  2003cites this paper
• Hedgehog promotes primary osteoblast differentiation and increases PTHrP mRNA expression and iPTHrP secretion.

  2003cites this paper
• Monoclonal antibody to parathyroid hormone-related protein induces differentiation and apoptosis of chondrosarcoma cells.

  2003cites this paper
• Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor.

  2003cites this paper
• FGF-2 increases colony formation, PTH receptor, and IGF-1 mRNA in mouse marrow stromal cells.

  2002cites this paper
• Parathyroid hormone-related protein in lower vertebrates.

  2002cites this paper
• Na+/H+ exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling

  2002cites this paper
• Molecular Basis of PTH Underexpression

  2002cites this paper
• Chapter 26 – Parathyroid Hormone-Receptor Interactions

  2002cites this paper
• Dexamethasone and retinoic acid differentially regulate growth and differentiation in an immortalised human clonal bone marrow stromal cell line with osteoblastic characteristics.

  2002cites this paper
• Hyperparathyroidism, Humoral Hypercalcemia of Malignancy, and the Anabolic Actions of Parathyroid Hormone and Parathyroid Hormone‐Related Protein on the Skeleton

  2002cites this paper
• Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol.

  2002cites this paper
• CHAPTER 9 – Immunoassays for PTH and PTHrP: Clinical Applications

  2001cites this paper
• CHAPTER 49 – The Molecular Genetics of Hypoparathyroidism

  2001cites this paper
• Biological activities of two porcine growth hormone-releasing hormone receptor isoforms.

  2001cites this paper