Central Hyperthermia Treated with Baclofen in a Patient with Epidural Hematoma

Central hyperthermia is characterized by a rapid-onset elevated temperature, marked temperature fluctuation, and poor response to antipyretics and antibiotics. It is caused by impairment of the central thermoregulatory pathways and is associated with high morbidity and mortality. We report on a case of 31-year old male who sustained fall injury with massive epidural hematoma and a high-grade fever of 40°C on presentation. Following cranio to my and evacuation of hematoma, antipyretics and antibiotics were used for high-grade fever but were not effective. Baclofen was orally administered which effectively controlled the fever. Here, we also discuss the possible central mechanisms for this effect of baclofen and show that baclofen may be an effective treatment in central hyperthermia. Nepal Journal of Neuroscience. Vol. 13, No. 2, 2016, Page: 102-104

• Publication year

  2016

• Venue

  Unknown venue

• Publication date

  2016-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.3126/NJN.V13I2.20488
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

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• No concepts are published for this paper.

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