Analysis of the trk NGF receptor tyrosine kinase using recombinant fusion proteins

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Cell Science

• Publication date

  1993-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.1993.Supplement_17.31PMID 8144701
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.

  1993cited by this paper
• The nerve growth factor family of receptors.

  1992cited by this paper
• Membrane depolarization induces p140trk and NGF responsiveness, but not p75LNGFR, in MAH cells.

  1992cited by this paper
• K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses.

  1992cited by this paper
• Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons.

  1992cited by this paper
• Growth factor signaling: where is the specificity?

  1992cited by this paper
• Neurotrophin receptors: a window into neuronal differentiation.

  1992cited by this paper
• Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: responses to injury and infusion of NGF

  1992cited by this paper
• Binding of neurotrophin‐3 to its neuronal receptors and interactions with nerve growth factor and brain‐derived neurotrophic factor.

  1992cited by this paper
• K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.

  1992cited by this paper
• p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF.

  1992cited by this paper
• K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.

  1992cited by this paper
• The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.

  1991cited by this paper
• Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

  1991cited by this paper
• High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

  1991cited by this paper
• The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.

  1991cited by this paper
• The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines.

  1991cited by this paper
• Molecular investigations on the high-affinity nerve growth factor receptor.

  1991cited by this paper
• trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3.

  1991influential reference
• The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3.

  1991influential reference
• trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor.

  1991influential reference
• The trk proto-oncogene encodes a receptor for nerve growth factor.

  1991cited by this paper
• A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors.

  1991cited by this paper
• Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: inhibition by antibodies to NGF.

  1991cited by this paper
• The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.

  1991influential reference
• Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.

  1991cited by this paper
• Tissue localization of nerve growth factor and nerve growth factor receptors.

  1991cited by this paper
• Binding of brain-derived neurotrophic factor to the nerve growth factor receptor.

  1990cited by this paper
• Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

  1990cited by this paper
• Trophic factors and neuronal survival.

  1989cited by this paper
• Molecular and biochemical characterization of the human trk proto-oncogene

  1989influential reference
• trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

  1989cited by this paper
• Molecular cloning and expression of brain-derived neurotrophic factor

  1989cited by this paper
• Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

  1988cited by this paper
• K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

  1988influential reference
• Molecular analysis of the nerve growth factor receptor.

  1988cited by this paper
• The physiological function of nerve growth factor in the central nervous system: comparison with the periphery.

  1987cited by this paper
• The nerve growth factor 35 years later.

  1987cited by this paper
• Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain.

  1987cited by this paper
• Nerve growth factor selectively increases cholinergic markers but not neuropeptides in rat basal forebrain in culture.

  1987cited by this paper
• A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

  1986cited by this paper
• A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor.

  1986cited by this paper
• Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor.

  1985cited by this paper
• Affinity labeling and partial purification of nerve growth factor receptors from rat pheochromocytoma and human melanoma cells.

  1983cited by this paper

• Nerve growth factor signaling, neuroprotection, and neural repair.

  2001cites this paper
• Expression of NGF and NT3 mRNAs in Hippocampal Interneurons Innervated by the GABAergic Septohippocampal Pathway

  1996cites this paper
• Expression of trk receptors in the developing and adult human central and peripheral nervous system

  1995cites this paper
• Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury.

  1995cites this paper
• Identification of the neurotrophin receptors p75 and trk in a series of Wilms' tumors.

  1994cites this paper
• Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors.

  1993cites this paper