Catalytic activity of certain antibodies as a potential tool for drug synthesis and for directed prodrug therapies.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Current Medicinal Chemistry

• Publication date

  2008-06-30

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2174/092986708784911533PMID 18673227
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation

  2007cited by this paper
• Antibody-catalyzed anaerobic destruction of methamphetamine

  2007cited by this paper
• Identification and characterization of single chain anti-cocaine catalytic antibodies.

  2007cited by this paper
• Positional linker effects in haptens for cocaine immunopharmacotherapy.

  2007cited by this paper
• Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol.

  2007cited by this paper
• Naturally occurring catalytic antibodies: evidence for preferred development of the catalytic function in IgA class antibodies

  2007cited by this paper
• Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs.

  2007cited by this paper
• Complete reaction cycle of a cocaine catalytic antibody at atomic resolution.

  2006cited by this paper
• Cannabis use and other illicit drug use: testing the cannabis gateway hypothesis.

  2006cited by this paper
• Human milk antibodies with polysaccharide kinase activity.

  2006cited by this paper
• Catalytic IgG from Patients with Hemophilia A Inactivate Therapeutic Factor VIII1

  2006cited by this paper
• Immunoglobulins can utilize riboflavin (Vitamin B2) to activate the antibody-catalyzed water oxidation pathway.

  2006cited by this paper
• Unexpected acetylcholinesterase activity of cocaine esterases.

  2006cited by this paper
• Physiopathology of catalytic antibodies: the case for factor VIII-hydrolyzing immunoglobulin G

  2006cited by this paper
• Catalytic autoantibodies in clinical autoimmunity and modern medicine.

  2006cited by this paper
• Catalytic activity of autoantibodies toward myelin basic protein correlates with the scores on the multiple sclerosis expanded disability status scale.

  2006cited by this paper
• Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol.

  2005cited by this paper
• Catalytic autoantibodies in multiple sclerosis: Pathogenetic and clinical aspects

  2005cited by this paper
• High levels of catalytic antibodies correlate with favorable outcome in sepsis.

  2005cited by this paper
• Antibody-catalyzed oxidative degradation of nicotine using riboflavin.

  2004cited by this paper
• Catalytic antibodies: hapten design strategies and screening methods.

  2004cited by this paper
• Investigations using immunization to attenuate the psychoactive effects of nicotine.

  2004cited by this paper
• Naturally Occurring Proteolytic Antibodies

  2004cited by this paper
• Enzyme/abzyme prodrug activation systems: potential use in clinical oncology.

  2003cited by this paper
• VIPase autoantibodies in Fas‐defective mice and patients with autoimmune disease

  2003cited by this paper
• Investigating antibody-catalyzed ozone generation by human neutrophils

  2003cited by this paper
• Does marijuana use cause the use of other drugs?

  2003cited by this paper
• Structural basis for antibody catalysis of a cationic cyclization reaction.

  2003cited by this paper
• Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens

  2003cited by this paper
• Roles of Vasoactive Intestinal Peptide (VIP) in the Expression of Different Immune Phenotypes by Wild-Type Mice and T Cell-Targeted Type II VIP Receptor Transgenic Mice1

  2003cited by this paper
• Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation

  2002cited by this paper
• New evidence for transmitter role of VIP in the airways: impaired relaxation by a catalytic antibody.

  2002cited by this paper
• Detection strategies for catalytic antibodies.

  2002cited by this paper
• Selective chemotherapeutic strategies using catalytic antibodies: a common pro-moiety for antibody-directed abzyme prodrug therapy.

  2002cited by this paper
• The role of CCR5 chemokine ligands and antibodies to CCR5 coreceptors in preventing HIV infection.

  2002cited by this paper
• Catalytic diversity of polyclonal RNA-hydrolyzing IgG antibodies from the sera of patients with systemic lupus erythematosus.

  2002cited by this paper
• First example of an antibody-catalyzed aza Diels-Alder reaction.

  2002cited by this paper
• Cocaine catalytic antibodies: the primary importance of linker effects.

  2001cited by this paper
• Antibody Catalysis of the Oxidation of Water

  2001cited by this paper
• gp120: Biologic aspects of structural features.

  2001cited by this paper
• A comparative analysis of the immunological evolution of antibody 28B4.

  2001cited by this paper
• In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy

  2001cited by this paper
• Autoantibodies to thyroglobulin in health and disease

  2000cited by this paper
• Antibodies have the intrinsic capacity to destroy antigens.

  2000cited by this paper
• Highly sensitive and rapid detection of antibody catalysis by luminescent bacteria.

  2000cited by this paper
• Shape Complementarity, Binding‐Site Dynamics, and Transition State Stabilization: A Theoretical Study of Diels–Alder Catalysis by Antibody 1E9

  2000cited by this paper
• Enzyme mimicry by the antiidiotypic antibody approach.

  2000cited by this paper
• Multiple event activation of a generic prodrug trigger by antibody catalysis.

  1999cited by this paper
• Catalytic activity of antibodies against factor VIII in patients with hemophilia A

  1999cited by this paper
• Novel functional activities of anti-dna autoantibodies from sera of patients with lymphoproliferative and autoimmune diseases

  1998cited by this paper
• Polyclonal antibodies from blood and cerebrospinal fluid of patients with multiple sclerosis effectively hydrolyze DNA and RNA.

  1998cited by this paper
• Functional mimicry: elicitation of a monoclonal antiidiotypic antibody hydrolizing β‐lactams

  1998cited by this paper
• Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis.

  1998cited by this paper
• Immune versus natural selection: antibody aldolases with enzymic rates but broader scope.

  1997cited by this paper
• DNA‐hydrolyzing activity of the light chain of IgG antibodies from milk of healthy human mothers

  1997cited by this paper
• Characterization of thyroglobulin-directed and polyreactive catalytic antibodies in autoimmune disease.

  1997cited by this paper
• Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution.

  1996cited by this paper
• Antibody-enzyme conjugates for cancer therapy.

  1996cited by this paper
• Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing.

  1996cited by this paper
• A general assay for antibody catalysis using acridone as a fluorescent tag.

  1996cited by this paper
• Catalytic cleavage of vasopressin by human Bence Jones proteins at the arginylglycinamide bond.

  1996cited by this paper
• Catalytic Activity of Anti‐Thyroglobulin Antibodies a

  1995cited by this paper
• Anti‐idiotypic antibodies: biological function and structural studies

  1995cited by this paper
• Encoded reaction cassette for the highly sensitive detection of the making and breaking of chemical bonds.

  1995cited by this paper
• Natural Catalytic Antibodies: Peptide-hydrolyzing Activities of Bence Jones Proteins and VL Fragment (*)

  1995cited by this paper
• Amidase activity of human Bence Jones proteins.

  1994cited by this paper
• Antibody catalyzed cationic cyclization.

  1994cited by this paper
• Site-specific conjugation of an enzyme and an antibody fragment.

  1994cited by this paper
• Prodrug activation via catalytic antibodies.

  1993cited by this paper
• Antibody-catalyzed degradation of cocaine.

  1993cited by this paper
• Monoclonal anti-idiotypic antibodies as functional internal images of enzyme active sites: production of a catalytic antibody with a cholinesterase activity.

  1993cited by this paper
• Controlling chemical reactivity with antibodies

  1993cited by this paper
• Polyclonal catalytic antibodies.

  1993cited by this paper
• catELISA: a facile general route to catalytic antibodies.

  1993cited by this paper
• DNA hydrolyzing autoantibodies.

  1992cited by this paper
• Cleavage of vasoactive intestinal peptide at multiple sites by autoantibodies.

  1991cited by this paper
• At the crossroads of chemistry and immunology: catalytic antibodies.

  1991cited by this paper
• Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody.

  1989cited by this paper
• Antibody-antigen complexes.

  1988cited by this paper
• Towards a network theory of the immune system.

  1973cited by this paper
• Nonsteroidal antiinflammatory agents. I. 6-substituted 2-naphthylacetic acids.

  1970cited by this paper

• A Brief View on the Role of Enzymes in the Diagnosis, Monitoring and Treatment of Diseases and their Application in Medical, Genetics and Proteomics Laboratory Methods

  2024cites this paper
• Catalytic Antibodies: Design, Expression, and Their Applications in Medicine

  2022cites this paper
• Fusion Proteins with Toxic Activity

  2013cites this paper
• Computational enzyme design.

  2013cites this paper
• Autoantibodies and Natural Catalytic Antibodies in Health, Multiple Sclerosis, and Some Other Diseases

  2012cites this paper
• Natural Catalytic Antibodies in Norm and in HIV-Infected Patients

  2011cites this paper
• Antibody-enzyme fusion proteins for cancer therapy.

  2011cites this paper
• Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases

  2010cites this paper
• De novo enzymes: from computational design to mRNA display.

  2010cites this paper
• Generation of transgenic plants expressing antibodies to the environmental pollutant microcystin‐LR

  2010cites this paper
• Studies toward the duocarmycin prodrugs for the antibody prodrug therapy approach.

  2009cites this paper