The maternal HLA-G 1597ΔC null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular human reproduction

• Publication date

  2013-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/molehr/gas041PMID 23002110PMCID PMC3579410
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012cited by this paper
• The role of genetics in pre-eclampsia and potential pharmacogenomic interventions

  2012cited by this paper
• Maternal ethnicity and pre-eclampsia in New York City, 1995-2003.

  2012cited by this paper
• Pre-eclampsia

  2010cited by this paper
• Overview of Maternal Morbidity During Hospitalization for Labor and Delivery in the United States: 1993 to 1997 and 2001 to 2005

  2010cited by this paper
• The 3'-untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited.

  2010cited by this paper
• Soluble human leukocyte antigen-G isoforms in maternal plasma in early and late pregnancy.

  2009cited by this paper
• Overview of Maternal Morbidity During Hospitalization for Labor and Delivery in the United States: 1993–1997 and 2001–2005

  2009cited by this paper
• Possible Gene-Gene Interaction of KIR2DL4 With its Cognate Ligand HLA-G in Modulating Risk for Preeclampsia

  2009cited by this paper
• The 14 bp deletion polymorphisms in HLA-G gene play an important role in the expression of soluble HLA-G in plasma.

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• Empirical data about women's attitudes towards a hypothetical pediatric biobank

  2008cited by this paper
• Implementing a Class of Permutation Tests: The coin Package

  2008cited by this paper
• Secular trends in the rates of preeclampsia, eclampsia, and gestational hypertension, United States, 1987-2004.

  2008cited by this paper
• Paternal contribution of HLA-G*0106 significantly increases risk for pre-eclampsia in multigravid pregnancies.

  2008cited by this paper
• The HLA-G 14bp gene polymorphism and decidual HLA-G 14bp gene expression in pre-eclamptic and normal pregnancies.

  2008cited by this paper
• A single base-pair mutation in the 3'-untranslated region of HLA-G mRNA is associated with pre-eclampsia.

  2008cited by this paper
• Genes and the preeclampsia syndrome

  2008cited by this paper
• Allele-specific targeting of microRNAs to HLA-G and risk of asthma.

  2007cited by this paper
• Early Detection of Decreased Soluble HLA‐G Levels in the Maternal Circulation Predicts the Occurrence of Preeclampsia and Intrauterine Growth Retardation During Further Course of Pregnancy

  2007cited by this paper
• HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.

  2007cited by this paper
• Reduced third-trimester levels of soluble human leukocyte antigen G protein in severe preeclampsia.

  2007cited by this paper
• Racial disparity in hypertensive disorders of pregnancy in New York State: a 10-year longitudinal population-based study.

  2007cited by this paper
• Maternal antigen presenting cells are a source of plasmatic HLA-G during pregnancy: longitudinal study during pregnancy.

  2007cited by this paper
• Immunogenetics of pregnancy: role of a 14-bp deletion in the maternal HLA-G gene in primiparous pre-eclamptic Brazilian women.

  2007cited by this paper
• Maternal human leukocyte antigen-G polymorphism is not associated with pre-eclampsia in a Chinese Han population.

  2006cited by this paper
• The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells.

  2006cited by this paper
• Preeclampsia: recent insights.

  2005cited by this paper
• Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia later in pregnancy.

  2005cited by this paper
• Maternal Ethnicity, Paternal Ethnicity, and Parental Ethnic Discordance: Predictors of Preeclampsia

  2005cited by this paper
• Evidence of balancing selection at the HLA-G promoter region.

  2005influential reference
• Latest Advances in Understanding Preeclampsia

  2005cited by this paper
• Combining probability from independent tests: the weighted Z‐method is superior to Fisher's approach

  2005cited by this paper
• Pre-eclampsia

  2005cited by this paper
• Association between HLA-G genotype and risk of pre-eclampsia: a case-control study using family triads.

  2004cited by this paper
• HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms

  2004cited by this paper
• Diagnosis and management of gestational hypertension and preeclampsia.

  2003cited by this paper
• Variation in the HLA-G promoter region influences miscarriage rates.

  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
• Point: population stratification: a problem for case-control studies of candidate-gene associations?

  2002cited by this paper
• Counterpoint: bias from population stratification is not a major threat to the validity of conclusions from epidemiological studies of common polymorphisms and cancer.

  2002cited by this paper
• Hypertension in pregnancy.

  2002cited by this paper
• The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion.

  2001cited by this paper
• Paternal and maternal components of the predisposition to preeclampsia.

  2001cited by this paper
• Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease

  2001cited by this paper
• HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage.

  2001cited by this paper
• Soluble HLA levels in early pregnancy after in vitro fertilization.

  2000cited by this paper
• Soluble HLA-G circulates in maternal blood during pregnancy.

  2000cited by this paper
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  2000influential reference
• HLA-G and HLA-E polymorphisms in an indigenous African population. The ZVITAMBO Study Group.

  2000cited by this paper
• Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy.

  2000cited by this paper
• Pre-eclampsia

  2000cited by this paper
• Re-examination of HLA-G polymorphism in African Americans

  1999cited by this paper
• Fetal and maternal contributions to risk of pre-eclampsia: population based study

  1998cited by this paper
• HLA-G1 protein expression is not essential for fetal survival.

  1998influential reference
• Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group.

  1997cited by this paper
• Maternal Hypertension and Associated Pregnancy Complications Among African‐American and Other Women in the united States

  1996cited by this paper
• A United States National Reference for Fetal Growth

  1996cited by this paper
• A class I antigen, HLA-G, expressed in human trophoblasts.

  1990cited by this paper
• The Familial Factor in Toxemia of Pregnancy

  1968cited by this paper

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  2025cites this paper
• Blood Pressure Thresholds for Hypertension in Pregnancy and Future Cardiovascular Risk.

  2025cites this paper
• Kidney health outcomes of hypertensive disorders of pregnancy

  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Analysis of HLA-G gene polymorphisms in Slovak women with pre-eclampsia.

  2017cites this paper
• The maternal 14 bp Ins/Del polymorphism in HLA‐G is not associated with preeclampsia risk

  2017influential citation
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015influential citation
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2011cites this paper