Cellular delivery of pyrenyl-arene ruthenium complexes by a water-soluble arene ruthenium metalla-cage.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Dalton Transactions

• Publication date

  2012-05-28

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/c2dt30193hPMID 22506276
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Delivery of floxuridine derivatives to cancer cells by water-soluble organometallic cages.

  2012cited by this paper
• Organometallic cages as vehicles for intracellular release of photosensitizers.

  2012cited by this paper
• Targeted and multifunctional arene ruthenium chemotherapeutics.

  2011cited by this paper
• Double targeting of tumours with pyrenyl-modified dendrimers encapsulated in an arene-ruthenium metallaprism.

  2011cited by this paper
• Encapsulation of pyrene-functionalized poly(benzyl ether) dendrons into a water-soluble organometallic cage.

  2011cited by this paper
• A ruthenium antimetastasis agent forms specific histone protein adducts in the nucleosome core.

  2011cited by this paper
• Use of perfluorinated phosphines to provide thermomorphic anticancer complexes for heat-based tumor targeting.

  2010cited by this paper
• Induced-fit binding of pi-electron-donor substrates to macrocyclic aromatic ether imide sulfones: a versatile approach to molecular assembly.

  2010cited by this paper
• Arene ruthenium complexes as anticancer agents.

  2010cited by this paper
• Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints.

  2010cited by this paper
• Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage.

  2010cited by this paper
• Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT.

  2010cited by this paper
• Permanent Encapsulation or Host–Guest Behavior of Aromatic Molecules in Hexanuclear Arene Ruthenium Prisms

  2010cited by this paper
• Evidence for drug release from a metalla-cage delivery vector following cellular internalisation.

  2010cited by this paper
• Guanidiniocarbonylpyrrole-aryl derivatives: structure tuning for spectrophotometric recognition of specific DNA and RNA sequences and for antiproliferative activity.

  2010cited by this paper
• Bioorganometallic chemistry--from teaching paradigms to medicinal applications.

  2009cited by this paper
• Rational design of an organometallic glutathione transferase inhibitor.

  2009cited by this paper
• Host–Guest Chemistry in the Hexanuclear (Arene)ruthenium Metalla‐Prismatic Cage [Ru6(p‐cymene)6(tpt)2(dhnq)3]6+

  2009cited by this paper
• Sawhorse-type diruthenium tetracarbonyl complexes containing porphyrin-derived ligands as highly selective photosensitizers for female reproductive cancer cells

  2009cited by this paper
• Vibrational and rotational structure and excited-state dynamics of pyrene.

  2009cited by this paper
• Modulation of the metastatic progression of breast cancer with an organometallic ruthenium compound.

  2008cited by this paper
• Encapsulation of Aromatic Molecules in Hexanuclear Arene Ruthenium Cages: A Strategy to Build Up Organometallic Carceplex Prisms with a Dangling Arm Standing Out

  2008cited by this paper
• Highly efficient quenching of excimer fluorescence by perylene diimide in DNA.

  2008cited by this paper
• Encapsulation of Triphenylene Derivatives in the Hexanuclear Arene Ruthenium Metallo-Prismatic Cage [Ru6(p-PriC6H4Me)6(tpt)2(dhbq)3]6+ (tpt = 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine, dhbq = 2,5-dihydroxy-1,4-benzoquinonato)

  2008cited by this paper
• Antitumour metal compounds: more than theme and variations.

  2008cited by this paper
• The design of organometallic ruthenium arene anticancer agents

  2007cited by this paper
• Organometallic Ruthenium Inhibitors of Glutathione‐S‐Transferase P1‐1 as Anticancer Drugs

  2007cited by this paper
• Development of ruthenium antitumor drugs that overcome multidrug resistance mechanisms.

  2007cited by this paper
• Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy.

  2007cited by this paper
• An efficient one-pot synthesis of unsymmetrical ethers: a directly reductive deoxygenation of esters using an InBr3/Et3SiH catalytic system.

  2007cited by this paper
• Systematic Design of a Targeted Organometallic Antitumour Drug in Pre-clinical Development

  2007cited by this paper
• Classical and Non‐Classical Ruthenium‐Based Anticancer Drugs: Towards Targeted Chemotherapy

  2006cited by this paper
• From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A).

  2006cited by this paper
• Influence of Hydrogen-Bonding Substituents on the Cytotoxicity of RAPTA Compounds

  2006cited by this paper
• In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes.

  2005cited by this paper
• A new class of "tethered" ruthenium(II) catalyst for asymmetric transfer hydrogenation reactions.

  2004cited by this paper
• [Ru(η6-p-cymene)Cl2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

  2001cited by this paper
• Factors Contributing to Aromatic Stacking in Water: Evaluation in the Context of DNA.

  2000cited by this paper
• Diffusion Ordered Nuclear Magnetic Resonance Spectroscopy: Principles and Applications

  1999cited by this paper
• Ligand binding by butadiyne-linked porphyrin dimers, trimers and tetramers

  1995cited by this paper
• Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides.

  1989cited by this paper
• A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

  1986cited by this paper
• Benzene Complexes of Ruthenium(II)

  1972cited by this paper

• Review of the Most Important Research Trends in Potential Chemotherapeutics Based on Coordination Compounds of Ruthenium, Rhodium and Iridium

  2025cites this paper
• Recent Trends in the Design of Ruthenium Homometallic Polynuclear Complexes with Bioactive Ligands for Cancer Treatment

  2025cites this paper
• Photoinduced energy and electron transfer processes in a supramolecular system combining a tetrapyrenylporphyrin derivative and arene-ruthenium metalla-prisms.

  2025cites this paper
• Exploring the toxicity of mononuclear piano-stool Ru(II) anticancer agents: A comprehensive literature review

  2025cites this paper
• Coordination-driven self-assembly formation of Ru(II)-metallocycles based on 4-amino-1,8-naphthalimide Tröger's base supramolecular scaffold: Synthesis, characterization, and heparin-binding study

  2024cites this paper
• Biomedical applications of multinuclear Pt(II)/Ru(II)/Ir(III) metallo-supramolecular assemblies for intensive cancer therapy

  2023cites this paper
• Recognition and mechanistic investigation of anion sensing by ruthenium(II) arene complexes and bio-imaging application.

  2022cites this paper
• COMC IV: Organometallic Receptors for Charged and Neutral Guest Species

  2021cites this paper
• Ruthenium(ii)-arene complexes as anti-metastatic agents, and related techniques.

  2021cites this paper
• Unmasking Arene Ruthenium Building Blocks

  2020cites this paper
• Design and Applications of Water-Soluble Coordination Cages

  2020cites this paper
• Multinuclear biologically active Ru, Rh, Os and Ir arene complexes

  2020cites this paper
• Exploring the Anticancer Potential of Diiron Bis-cyclopentadienyl Complexes with Bridging Hydrocarbyl Ligands: Behavior in Aqueous Media and In Vitro Cytotoxicity

  2020cites this paper
• Biomedically Relevant Self-Assembled Metallacycles and Metallacages.

  2019cites this paper
• Recent advances in ruthenium and platinum based supramolecular coordination complexes for antitumor therapy.

  2019cites this paper
• Designing Ruthenium Anticancer Drugs: What Have We Learnt from the Key Drug Candidates?

  2019cites this paper
• University of Birmingham Designing ruthenium anticancer drugs

  2019cites this paper
• Recent Developments of Supramolecular Metal-based Structures for Applications in Cancer Therapy and Imaging

  2019cites this paper
• Self-assembly of supramolecular coordination complexes based on half-sandwich metal corner with tunable host cavities

  2019cites this paper
• Arene Ruthenium Metalla-Assemblies with Anthracene Moieties for PDT Applications

  2018cites this paper
• Self-Assembled PdII6 Molecular Spheroids and Their Proton Conduction Property.

  2018cites this paper
• Polynuclear ruthenium organometallic complexes containing a 1,3,5-triazine ligand: synthesis, DNA interaction, and biological activity

  2018cites this paper
• Self-Assembly of Discrete RuII8 Molecular Cages and Their in Vitro Anticancer Activity.

  2017cites this paper
• Ruthenium Anticancer Agents—From Cisplatin Analogues to Rational Drug Design

  2017cites this paper
• Ruthenium Anticancer Agents En Route to the Tumor

  2017cites this paper
• Arene Ruthenium(II) Complexes with Phosphorous Ligands as Possible Anticancer Agents.

  2017cites this paper
• Ruthenium‐Based Anticancer Compounds: Insights into Their Cellular Targeting and Mechanism of Action

  2017cites this paper
• Versatility of Two Diimidazole Building Blocks in Coordination-Driven Self-Assembly.

  2017cites this paper
• M2L4 coordination capsules with tunable anticancer activity upon guest encapsulation.

  2016cites this paper
• Exploring the Ruthenium-Ligands Bond and Their Relative Properties at Different Computational Methods

  2016cites this paper
• Anticancer activity of large metalla-assemblies built from half-sandwich complexes

  2016cites this paper
• The development of RAPTA compounds for the treatment of tumors

  2016cites this paper
• Tunable Arene Ruthenium Metallaprisms to Transport, Shield, and Release Porphin in Cancer Cells

  2015cites this paper
• Metal-organic molecular cages: applications of biochemical implications.

  2015cites this paper
• Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery.

  2015cites this paper
• Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes.

  2015cites this paper
• Biologically relevant arene ruthenium metalla-assemblies

  2015cites this paper
• Development of ruthenium-based complexes as anticancer agents: toward a rational design of alternative receptor targets

  2015cites this paper
• Biologically active [Pd2L4](4+) quadruply-stranded helicates: stability and cytotoxicity.

  2015cites this paper
• A Pd8 Tetrafacial Molecular Barrel as Carrier for Water Insoluble Fluorophore.

  2015cites this paper
• ANTICANCER ACTIVITY OF VARIOUS TRANSITION METAL COMPLEXES: A REVIEW

  2015cites this paper
• Metallophilicity-assisted assembly of phosphine-based cage molecules.

  2014cites this paper
• Organometallic Complexes as Enzyme Inhibitors: A Conceptual Overview

  2014cites this paper
• In vivo anticancer activity of rhomboidal Pt(II) metallacycles

  2014cites this paper
• Recent advances in supramolecular and biological aspects of arene ruthenium(II) complexes

  2014cites this paper
• Multifaceted half-sandwich arene–ruthenium complexes: interactions with biomolecules, photoactivation, and multinuclearity approach

  2014cites this paper
• ‘Click’ to functionalise: synthesis, characterisation and enhancement of the physical properties of a series of exo- and endo-functionalised Pd2L4 nanocages

  2014cites this paper
• Enhanced delivery of the RAPTA-C macromolecular chemotherapeutic by conjugation to degradable polymeric micelles.

  2013cites this paper
• Discrete Metalla‐Assemblies as Drug Delivery Vectors

  2013cites this paper
• Ruthenium Compounds as Antitumor Agents: New Developments

  2013cites this paper
• Transporting and shielding photosensitisers by using water-soluble organometallic cages: a new strategy in drug delivery and photodynamic therapy.

  2013cites this paper
• Synthesis, characterisation and in vitro anticancer activity of hexanuclear thiolato-bridged arene ruthenium metalla-prisms.

  2013cites this paper
• BODIPY-phosphane as a versatile tool for easy access to new metal-based theranostics.

  2013cites this paper
• Synthesis, characterisation and biological activities of [(p-cym)RuX(pz4lut)]n+ and [{(p-cym)RuX}2(μ-pz4lut)]n+ (X = Cl, H2O and pz4lut = α,α,α',α'-tetra(pyrazol-1-yl)-2,6-lutidine).

  2013cites this paper
• A cyclometallated platinum complex as a selective optical switch for quadruplex DNA.

  2012cites this paper
• Macromolecular ruthenium complexes as anti-cancer agents

  2012cites this paper