Multilocus Family-Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African-Derived Semi-Isolated Brazilian Population

Background. It has been widely suggested that analyses considering multilocus effects would be crucial to characterize the relationship between gene variability and essential hypertension (EH). Objective. To test for the presence of multilocus effects between/among seven polymorphisms (six genes) on blood pressure-related traits in African-derived semi-isolated Brazilian populations (quilombos). Methods. Analyses were carried out using a family-based design in a sample of 652 participants (97 families). Seven variants were investigated: ACE (rs1799752), AGT (rs669), ADD2 (rs3755351), NOS3 (rs1799983), GNB3 (rs5441 and rs5443), and GRK4 (rs1801058). Sensitivity analyses were further performed under a case-control design with unrelated participants only. Results. None of the investigated variants were associated individually with both systolic and diastolic BP levels (SBP and DBP, respectively) or EH (as a binary outcome). Multifactor dimensionality reduction-based techniques revealed a marginal association of the combined effect of both GNB3 variants on DBP levels in a family-based design (P = 0.040), whereas a putative NOS3-GRK4 interaction also in relation to DBP levels was observed in the case-control design only (P = 0.004). Conclusion. Our results provide limited support for the hypothesis of multilocus effects between/among the studied variants on blood pressure in quilombos. Further larger studies are needed to validate our findings.

• Publication year

  2012

• Venue

  International Journal of Hypertension

• Publication date

  2012-09-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2012/859219PMID 23056922PMCID 3463917
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Abnormalities in renal dopamine signaling and hypertension: the role of GRK4

  2012cited by this paper
• I and J

  2012cited by this paper
• Promotion, prevention and arterial hypertension care in Brazil.

  2012cited by this paper
• Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults

  2012cited by this paper
• A Review of Genetics, Arterial Stiffness, and Blood Pressure in African Americans

  2012cited by this paper
• Afro-Derived Amazonian Populations: Inferring Continental Ancestry and Population Substructure

  2011cited by this paper
• [Nutrition and health in children from former slave communities (quilombos) in the state of Alagoas, Brazil].

  2011cited by this paper
• Who were the male founders of rural Brazilian Afro-derived communities? A proposal based on three populations

  2011cited by this paper
• Multilocus Analyses of Seven Candidate Genes Suggest Interacting Pathways for Obesity‐Related Traits in Brazilian Populations

  2011cited by this paper
• Association of α-Adducin and G-Protein β3 Genetic Polymorphisms with Hypertension: A Meta-Analysis of Chinese Populations

  2011cited by this paper
• Nutrição e saúde das crianças das comunidades remanescentes dos quilombos no Estado de Alagoas, Brasil

  2011cited by this paper
• Blood pressure loci identified with a gene-centric array.

  2011cited by this paper
• Association of Hypertension Drug Target Genes With Blood Pressure and Hypertension in 86 588 Individuals

  2011cited by this paper
• An NOS3 Haplotype is Protective against Hypertension in a Caucasian Population

  2010cited by this paper
• Variants in Genes Involved in Functional Pathways Associated with Hypertension in African Americans

  2010cited by this paper
• FAM-MDR: A Flexible Family-Based Multifactor Dimensionality Reduction Technique to Detect Epistasis Using Related Individuals

  2010cited by this paper
• Prevalência de diagnóstico auto-referido de osteoporose, Brasil, 2006

  2009cited by this paper
• Prevalence of self-reported diagnosis of osteoporosis in Brazil, 2006.

  2009cited by this paper
• Frequency of arterial hypertension and associated factors: Brazil, 2006.

  2009cited by this paper
• Discovery properties of genome-wide association signals from cumulatively combined data sets.

  2009cited by this paper
• Heritability of cardiovascular risk factors in a Brazilian population: Baependi Heart Study

  2008cited by this paper
• BMC Medical Genetics BioMed Central Research article

  2008cited by this paper
• Meta-Analysis of the Association of 4 Angiotensinogen Polymorphisms With Essential Hypertension: A Role Beyond M235T?

  2008cited by this paper
• Maximizing association statistics over genetic models

  2008cited by this paper
• Improving strategies for detecting genetic patterns of disease susceptibility in association studies

  2008cited by this paper
• Meta-Analysis of the Association of 4 Angiotensinogen Polymorphisms With Essential Hypertension A Role Beyond M 235 T ?

  2008cited by this paper
• The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14 094 cases and 17 760 controls

  2007cited by this paper
• A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies

  2007cited by this paper
• Frequency and Origins of Hemoglobin S Mutation in African-Derived Brazilian Populations

  2007cited by this paper
• Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias

  2007cited by this paper
• A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.

  2007cited by this paper
• Influence of cultivation temperature on the ligninolytic activity of selected fungal strains

  2006cited by this paper
• Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure

  2005cited by this paper
• G Protein β3 Subunit Gene Variants and Essential Hypertension in the Northern Chinese Han Population

  2005cited by this paper
• Polymorphic Alu insertions in six Brazilian African‐derived populations

  2004cited by this paper
• Multilocus Analysis of Hypertension: A Hierarchical Approach

  2004cited by this paper
• Distribution of CGG repeats and FRAXAC1/DXS548 alleles in South American populations.

  2002cited by this paper
• Implementing a unified approach to family‐based tests of association

  2000cited by this paper
• Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci.

  1999cited by this paper
• Review of Genetics

  1970cited by this paper
• A and V

  1962cited by this paper

• Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations

  2025cites this paper
• Genomic Exploration of Essential Hypertension in African‐Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family‐Based Association Studies

  2025cites this paper
• G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets

  2024cites this paper
• Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach with Pedigree Analysis and Family-Based Association Studies

  2024cites this paper
• Malezya'daki Malaylar Arasında İrritabl Bağırsak Sendromu (IBS) ile ilişkili Tek Nükleotid Polimorfizmlerinin Genotip ve Alel Frekansları

  2023cites this paper
• Dopamine Receptor D1R and D3R and GRK4 Interaction in Hypertension

  2023cites this paper
• A review of ancestrality and admixture in Latin America and the caribbean focusing on native American and African descendant populations

  2023cites this paper
• Ancestry, diversity, and genetics of health-related traits in African-derived communities (quilombos) from Brazil

  2023cites this paper
• Panorama da hipertensão arterial nos quilombos do Brasil: uma revisão narrativa

  2023cites this paper
• Overview of Arterial Hypertension in Quilombos in Brazil: A Narrative Review

  2023cites this paper
• Variante da Subunidade Beta 3 da Proteína G ( GNB3 ) Está Associada a Alterações Bioquímicas em Pacientes Brasileiros com Hipertensão

  2023cites this paper
• Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.

  2022cites this paper
• Cardiovascular risk factors across different levels of urbanization in Brazilian Afro‐derived communities (quilombos)

  2022cites this paper
• Hypertension is associated with a variant in the RARRES2 gene in populations of Ouro Preto, Minas Gerais, Brazil: a cross-sectional study.

  2021cites this paper
• Comparação dos efeitos anti-hipertensivos da S-nitrosoglutationa livre e nanoencapsulada em modelo animal de hipertensão

  2020cites this paper
• Lipid Rafts and Dopamine Receptor Signaling

  2020cites this paper
• High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil

  2020cites this paper
• Short Editorial: Hypertension in Special Populations: An Epidemiological Challenge

  2019cites this paper
• Prevalence of Systemic Arterial Hypertension in Quilombola Communities, State of Sergipe, Brazil

  2019cites this paper
• [Arterial prehypertension in slave-descendant communities in southeast Bahia State, Brazil].

  2017cites this paper
• DIFFERENT ANGIOTENSIN RECEPTOR BLOCKERS IN EXPERIMENTALLY INDUCED HYPERTENSIVE ADULT MALE ALBINO RATS

  2017influential citation
• Inbreeding studies in a quilombo isolate from the state of São Paulo

  2017cites this paper
• Influence of fat intake and BMI on the association of rs1799983 NOS3 polymorphism with blood pressure levels in an Iberian population

  2017cites this paper
• Pré-hipertensão arterial em comunidades quilombolas do sudoeste da Bahia, Brasil.

  2017cites this paper
• Detecting multi-way epistasis in family-based association studies

  2016cites this paper
• Gastrorenal Axis

  2016cites this paper
• Population variation of HLA genes in rural communities in Brazil, the Quilombos from the Vale do Ribeira, São Paulo - Brazil.

  2016cites this paper
• 7th Brazilian Guideline of Arterial Hypertension: Chapter 1 - Concept, Epidemiology and Primary Prevention

  2016cites this paper
• G Protein–Coupled Receptor Kinases: Crucial Regulators of Blood Pressure

  2016cites this paper
• Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

  2015cites this paper
• Estimation of Inbreeding and Substructure Levels in African-Derived Brazilian Quilombo Populations

  2015cites this paper
• Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

  2015cites this paper
• Association study of NOS3 gene polymorphisms and hypertension in the Han Chinese population.

  2015cites this paper
• G Protein-Coupled Receptor Kinase 4: Role in Hypertension

  2015cites this paper
• Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade

  2015cites this paper
• Elevated blood pressure: Our family's fault? The genetics of essential hypertension.

  2014cites this paper
• Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

  2014cites this paper
• Overweight in Goiás'quilombola students and food insecurity in their families

  2014cites this paper
• Genetics and genomics in Brazil: a promising future

  2014cites this paper
• Estimativa de parâmetros genético-populacionais de interesse em isolados populacionais do Vale do Ribeira (remanescentes de quilombos)

  2013cites this paper
• Clinical Interventions in Aging Dovepress

  year unknowncites this paper