Chapter 6. Perspectives on Amyloid and Alzheimer's Disease: A Critical Review

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Annual Reports in Medicinal Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0065-7743(08)60876-3
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

  1993cited by this paper
• Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

  1993cited by this paper
• Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

  1993cited by this paper
• Neurotoxicity of β-amyloid

  1993cited by this paper
• Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

  1993cited by this paper
• Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

  1992cited by this paper
• Secretory pathway of beta/A4 amyloid protein precursor in familial Alzheimer's disease with Val717 to Ile mutation.

  1992cited by this paper
• Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity.

  1992cited by this paper
• Amyloid β-peptide is produced by cultured cells during normal metabolism

  1992cited by this paper
• Beta-amyloid precursor protein cleavage by a membrane-bound protease.

  1992cited by this paper
• Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

  1992cited by this paper
• An Alternative Secretase Cleavage Produces Soluble Alzheimer Amyloid Precursor Protein Containing a Potentially Amyloidogenic Sequence

  1992cited by this paper
• Progressive dementia, without cerebral hemorrhage, in a patient with hereditary cerebral amyloid angiopathy.

  1992cited by this paper
• beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology.

  1992cited by this paper
• In vivo effects of β-amyloid implants in rodents: lack of potentiation of damage associated with transient global forebrain ischemia

  1992cited by this paper
• Commentary and perspective on studies of beta amyloid neurotoxicity.

  1992cited by this paper
• Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.

  1992cited by this paper
• Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

  1992cited by this paper
• Failure of beta-amyloid protein fragment 25-35 to cause hippocampal damage in the rat.

  1992cited by this paper
• Vitamin E protects nerve cells from amyloid βprotein toxicity

  1992cited by this paper
• Inability of β‐amyloid (25–35) to bind to central nervous system neurokinin 1 receptors

  1992cited by this paper
• Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

  1992cited by this paper
• beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

  1992cited by this paper
• Solvent effects on beta protein toxicity in vivo.

  1992cited by this paper
• Effect of beta amyloid peptides on neurons in hippocampal slice cultures.

  1992cited by this paper
• The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected beta-amyloid in the rat brain.

  1992cited by this paper
• In vivo neurotoxicity of beta-amyloid [β(1–40)] and the β(25–35) fragment

  1992cited by this paper
• A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene

  1992cited by this paper
• Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

  1992cited by this paper
• Lack of alzheimer pathology after β-amyloid protein injections in rat brain

  1992cited by this paper
• Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

  1992cited by this paper
• Synthetic amyloid β-protein fails to produce specific neurotoxicity in monkey cerebral cortex

  1992cited by this paper
• Implants containing beta-amyloid protein are not neurotoxic to young and old rat brain.

  1992cited by this paper
• Intracerebral /sB-amyloid(25–35) produces tissue damage: Is it neurotoxic?

  1992cited by this paper
• β-Amyloid precursor protein and alzheimer's disease: The peptide plot thickens

  1992cited by this paper
• Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.

  1992cited by this paper
• β-amyloid peptide in vitro toxicity: Lot-to-lot variability

  1992cited by this paper
• The neurotoxic carboxy-terminal fragment of the Alzheimer amyloid precursor binds specifically to a neuronal cell surface molecule: pH dependence of the neurotoxicity and the binding

  1992cited by this paper
• A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

  1992cited by this paper
• Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

  1992cited by this paper
• Amyloid beta-protein fragment 25-35 causes activation of cytoplasmic calcium in neurons.

  1992cited by this paper
• Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.

  1992cited by this paper
• Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

  1992cited by this paper
• Complement activation by beta-amyloid in Alzheimer disease.

  1992cited by this paper
• Age-associated inclusions in normal and transgenic mouse brain

  1992cited by this paper
• Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor

  1992cited by this paper
• Alzheimer's retraction

  1992cited by this paper
• Expression of a carboxy-terminal region of the beta-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity.

  1992cited by this paper
• Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.

  1991cited by this paper
• Formation of β-amyloid protein deposits in brains of transgenic mice

  1991cited by this paper
• Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

  1991cited by this paper
• Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

  1991cited by this paper
• Amyloid beta protein substituent peptides do not interact with the substance P receptor expressed in cultured cells.

  1991cited by this paper
• APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease.

  1991cited by this paper
• "Secretase," Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific.

  1991cited by this paper
• Effects of injected Alzheimer beta-amyloid cores in rat brain.

  1991cited by this paper
• Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.

  1991cited by this paper
• Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.

  1991cited by this paper
• Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.

  1991cited by this paper
• An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

  1991cited by this paper
• Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.

  1991cited by this paper
• A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.

  1991cited by this paper
• The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.

  1991cited by this paper
• Deposits of amyloid beta protein in the central nervous system of transgenic mice.

  1991cited by this paper
• A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

  1991cited by this paper
• Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory

  1991cited by this paper
• Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation.

  1991cited by this paper
• Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures.

  1991cited by this paper
• Coca chewing and cholera.

  1991cited by this paper
• In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity ☆

  1991cited by this paper
• Genomic organization of the human-amyloid beta-protein precursor gene.

  1990cited by this paper
• Cleavage of amyloid beta peptide during constitutive processing of its precursor.

  1990cited by this paper
• Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.

  1990cited by this paper
• β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

  1990cited by this paper
• Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons.

  1990cited by this paper
• Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

  1990cited by this paper
• Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.

  1990cited by this paper
• Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.

  1989cited by this paper
• Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

  1989cited by this paper
• The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

  1989cited by this paper
• Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

  1989cited by this paper
• Amyloid beta protein enhances the survival of hippocampal neurons in vitro.

  1989cited by this paper
• A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

  1988cited by this paper
• Soviet-Based Global Foundation Takes Shape: Sakharov is a key player in a group that aims to fund a broad range of peace and environment projects.

  1988cited by this paper
• Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

  1987cited by this paper
• The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

  1987cited by this paper
• A neuronal antigen in the brains of Alzheimer patients.

  1986cited by this paper
• Amyloid plaque core protein in Alzheimer disease and Down syndrome.

  1985cited by this paper
• Diagnosis of Alzheimer's disease.

  1985cited by this paper
• Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

  1985cited by this paper
• Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

  1984cited by this paper

• Molecular Simulation of Solution Conformations of the Amyloid β-Peptide Aβ(1–42) by a Backpropagation Neural Network Model

  2001cites this paper
• Molecular Simulation of the Amyloid β-Peptide Aβ-(1-40) of Alzheimer's Disease

  1998cites this paper
• Molecular simulation of the primary and secondary structures of the Aβ(1‐42)‐peptide of Alzheimer's disease

  1998cites this paper
• DRUG DESIGN : THE PRESENT AND THE FUTURE

  1995cites this paper
• Synthesis and formulation for biological study of the β-amyloid(1–42) polypeptide

  1995cites this paper
• A chemical approach to elucidate tin mechanism of transthyretin and β-protein amyloid fibril formation

  1994cites this paper
• The Decade of the Brain Initiative and Health Care Reform: Irreconcilable Differences?

  1994cites this paper