Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model

Highlights • Malaria remains one of the world's major killers.• Partially effective vaccines against malaria are in development.• We profiled global gene expression after two candidate vaccine regimens.• Key pathways of vaccine response include interferon induced genes and the proteasome.• Global immune profiling approaches are necessary to improve candidate malaria vaccines.

• Publication year

  2015

• Venue

  Vaccine

• Publication date

  2015-09-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.vaccine.2015.07.087PMID 26256523PMCID 4582771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

  2014cited by this paper
• Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites

  2014cited by this paper
• Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines

  2014cited by this paper
• Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data

  2013cited by this paper
• The Ratio of Monocytes to Lymphocytes in Peripheral Blood Correlates with Increased Susceptibility to Clinical Malaria in Kenyan Children

  2013cited by this paper
• Evidence for additive and interaction effects of host genotype and infection in malaria

  2012cited by this paper
• A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine

  2011cited by this paper
• AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

  2011cited by this paper
• World malaria report 2011

  2011cited by this paper
• Visual Representation of Scientific Information

  2011cited by this paper
• Introduction to Statistical Methods for Analyzing Large Data Sets: Gene-Set Enrichment Analysis

  2011cited by this paper
• T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children

  2011cited by this paper
• Systems Biology of Seasonal Influenza Vaccination in Humans

  2011cited by this paper
• Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine.

  2010cited by this paper
• MIG and the Regulatory Cytokines IL-10 and TGF-β1 Correlate with Malaria Vaccine Immunogenicity and Efficacy

  2010cited by this paper
• Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection.

  2009cited by this paper
• Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

  2009cited by this paper
• Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research.

  2008cited by this paper
• A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus.

  2008cited by this paper
• A systems biology approach for pathway level analysis.

  2007influential reference
• Distinct gene expression profiles in peripheral blood mononuclear cells from patients infected with vaccinia virus, yellow fever 17D virus, or upper respiratory infections.

  2007cited by this paper
• Antigen Presentation and the Ubiquitin‐Proteasome System in Host–Pathogen Interactions

  2006cited by this paper
• A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS.

  2006cited by this paper
• A DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccine Encoding Thrombospondin-Related Adhesion Protein but Not Circumsporozoite Protein Partially Protects Healthy Malaria-Naive Adults against Plasmodium falciparum Sporozoite Challenge

  2006cited by this paper
• Common and Divergent Immune Response Signaling Pathways Discovered in Peripheral Blood Mononuclear Cell Gene Expression Patterns in Presymptomatic and Clinically Apparent Malaria

  2006cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites.

  2005cited by this paper
• Genomewide analysis of the host response to malaria in Kenyan children.

  2005cited by this paper
• The global distribution of clinical episodes of Plasmodium falciparum malaria

  2005cited by this paper
• Transcriptional analysis of human peripheral blood mononuclear cells after influenza immunization.

  2004cited by this paper
• A CD4+ T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease

  2004cited by this paper
• A single-nucleotide substitution from C to T at position −1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand

  2003cited by this paper
• Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans

  2003cited by this paper
• Ex vivo interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of Plasmodium falciparum infection.

  2003cited by this paper
• Protective Immunity Induced with Malaria Vaccine, RTS,S, Is Linked to Plasmodium falciparum Circumsporozoite Protein-Specific CD4+ and CD8+ T Cells Producing IFN-γ1

  2003cited by this paper
• Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria.

  2002cited by this paper
• Induction of CD4+ T cell-dependent CD8+ type 1 responses in humans by a malaria DNA vaccine

  2001cited by this paper
• Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine.

  1999cited by this paper
• Frequency of cytokine-producing T cells in patients of different age groups with Plasmodium falciparum malaria.

  1999cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• Amplified RNA synthesized from limited quantities of heterogeneous cDNA.

  1990cited by this paper
• The Walter Reed Army Institute of Research.

  1961cited by this paper

• Lung transcriptomics of K18-hACE2 mice highlights mechanisms and genes involved in the MVA-S vaccine-mediated immune response and protection against SARS-CoV-2 infection.

  2023cites this paper
• Controlled Human Infection Models To Accelerate Vaccine Development

  2022cites this paper
• Correlates of malaria vaccine efficacy

  2021cites this paper
• Helicobacter pylori.

  2021cites this paper
• The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection

  2020cites this paper
• Decoding the complexities of human malaria through systems immunology

  2020cites this paper
• The Application of Single-Cell RNA Sequencing in Vaccinology

  2020cites this paper
• Current Challenges in Vaccinology

  2020cites this paper
• Human challenge models: tools to accelerate the development of malaria vaccines

  2019cites this paper
• Blood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks

  2019cites this paper
• Deciphering genetic regulation of CD14 by SP1 through characterization of peripheral blood mononuclear transcriptome of P. faiciparum and P. vivax infected malaria patients

  2018cites this paper
• Investigating zoonotic infection barriers to ape Plasmodium parasites using faecal DNA analysis.

  2018cites this paper
• Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions

  2018cites this paper
• Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent period

  2018cites this paper
• Vaccines Meet Big Data: State-of-the-Art and Future Prospects. From the Classical 3Is (“Isolate–Inactivate–Inject”) Vaccinology 1.0 to Vaccinology 3.0, Vaccinomics, and Beyond: A Historical Overview

  2018cites this paper
• Investigating calcium channel blockers as antimalarials

  2018cites this paper
• Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systems

  2017cites this paper
• Transcriptomics in Human Challenge Models

  2017cites this paper
• Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans

  2017cites this paper
• Accelerating tuberculosis vaccine trials with diagnostic and prognostic biomarkers

  2017cites this paper
• Controlled Human Malaria Infection: Applications, Advances, and Challenges

  2017cites this paper
• Progress and prospects for blood-stage malaria vaccines

  2016cites this paper
• Profiling the host response to malaria vaccination and malaria challenge

  2015cites this paper
• Big Data in Vaccinology: Introduction and section summaries.

  2015cites this paper