Chapter 9 Amplicon-Based Herpes Simplex Virus Vectors

Publisher Summary The wide host range of herpes simplex virus type 1 (HSV-I), both in vivo and in vitro , and the relative ease of its genetic manipulation have made it an attractive candidate as a tool for gene transfer. Two different types of HSV vectors have been developed. For the first type, the recombinant virus vector, the gene of interest is inserted into the backbone. The second type of HSV vector is amplicon-based and has been termed the defective virus vector. This chapter focuses on the components and construction of amplicon-based vectors. The development of amplicon-based vectors has capitalized on the natural occurrence of defective interfering viruses (DI particles) that arise during high-multiplicity propagation of viruses. DI particles are subgenomic viral particles that lack an essential portion of the genome, require the complementation of homologous “helper” virus for replication, and thus “interfere” with the replication of the helpers by replicating at their expense when infecting the same cell.

• Publication year

  1994

• Venue

  Methods in Cell Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0091-679X(08)60604-4
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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