Blood–spinal cord barrier breakdown and pericyte deficiency in peripheral neuropathy

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Annals of the New York Academy of Sciences

• Publication date

  2017-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/nyas.13436PMID 28753236
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain.

  2016cited by this paper
• Early alterations of Hedgehog signaling pathway in vascular endothelial cells after peripheral nerve injury elicit blood-nerve barrier disruption, nerve inflammation, and neuropathic pain development

  2016cited by this paper
• Barrier function in the peripheral and central nervous system—a review

  2016cited by this paper
• Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells*

  2016cited by this paper
• Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

  2016cited by this paper
• Spinal CXCL5 contributes to nerve injury-induced neuropathic pain via modulating GSK-3β phosphorylation and activity in rats.

  2016cited by this paper
• Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

  2016cited by this paper
• Pericytes of the neurovascular unit: key functions and signaling pathways

  2016cited by this paper
• Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury.

  2016cited by this paper
• Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier.

  2016cited by this paper
• Dynamics of spinal microglia repopulation following an acute depletion

  2016cited by this paper
• Differential Transcriptional Profiling of Damaged and Intact Adjacent Dorsal Root Ganglia Neurons in Neuropathic Pain

  2015cited by this paper
• The role of glia in the spinal cord in neuropathic and inflammatory pain.

  2015cited by this paper
• Expression of the ALS-Causing Variant hSOD1G93A Leads to an Impaired Integrity and Altered Regulation of Claudin-5 Expression in an in Vitro Blood–Spinal Cord Barrier Model

  2015cited by this paper
• Ischemia–Reperfusion Injury Induces Occludin Phosphorylation/Ubiquitination and Retinal Vascular Permeability in a VEGFR-2-Dependent Manner

  2014cited by this paper
• Molecular mechanisms of epithelial–mesenchymal transition

  2014cited by this paper
• Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2

  2014cited by this paper
• Safety, efficacy, and molecular mechanism of claudin-1-specific peptides to enhance blood-nerve-barrier permeability.

  2014cited by this paper
• Abnormal junctions and permeability of myelin in PMP22‐deficient nerves

  2014cited by this paper
• Quantifying blood-spinal cord barrier permeability after peripheral nerve injury in the living mouse

  2014cited by this paper
• Expressions of Tight Junction Proteins Occludin and Claudin-1 Are under the Circadian Control in the Mouse Large Intestine: Implications in Intestinal Permeability and Susceptibility to Colitis

  2014cited by this paper
• Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

  2014cited by this paper
• Blood‐nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief

  2014cited by this paper
• Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

  2013cited by this paper
• Interactions between Twist and other core epithelial–mesenchymal transition factors are controlled by GSK3-mediated phosphorylation

  2013cited by this paper
• Recruitment and retention: factors that affect pericyte migration

  2013cited by this paper
• CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity

  2013cited by this paper
• Nerve Injury-related Autoimmunity Activation Leads to Chronic Inflammation and Chronic Neuropathic Pain

  2013cited by this paper
• Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action.

  2012cited by this paper
• Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

  2012cited by this paper
• Modulation of Tight Junction Structure and Function by Kinases and Phosphatases Targeting Occludin

  2012cited by this paper
• Blood–spinal cord barrier pericyte reductions contribute to increased capillary permeability

  2012cited by this paper
• Transient opening of the perineurial barrier for analgesic drug delivery

  2012cited by this paper
• Peripheral Nerve Injury Alters Blood–Spinal Cord Barrier Functional and Molecular Integrity through a Selective Inflammatory Pathway

  2011cited by this paper
• AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane*♦

  2011cited by this paper
• Non‐proteolytic house dust mite allergen, Der p 2, upregulated expression of tight junction molecule claudin‐2 associated with Akt/GSK‐3β/β‐catenin signaling pathway

  2011cited by this paper
• Claudin-1 induced sealing of blood–brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

  2011cited by this paper
• The blood–spinal cord barrier: Morphology and Clinical Implications

  2011cited by this paper
• Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells.

  2011cited by this paper
• Tricellulin Is Expressed in Autotypic Tight Junctions of Peripheral Myelinating Schwann Cells

  2010cited by this paper
• Glycogen Synthase Kinase 3 (GSK-3) influences epithelial barrier function by regulating occludin, claudin-1 and E-cadherin expression.

  2010cited by this paper
• Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier

  2010cited by this paper
• Neuropathological differences between rats and mice after spinal cord injury

  2010cited by this paper
• Interactions between the immune and nervous systems in pain

  2010cited by this paper
• Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability.

  2009cited by this paper
• DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

  2009cited by this paper
• Immune cell-derived opioids protect against neuropathic pain in mice.

  2009cited by this paper
• Mycobacteria Attenuate Nociceptive Responses by Formyl Peptide Receptor Triggered Opioid Peptide Release from Neutrophils

  2009cited by this paper
• Structure and function of claudins.

  2008cited by this paper
• Loss of occludin affects tricellular localization of tricellulin.

  2008cited by this paper
• Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.

  2008cited by this paper
• ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

  2008cited by this paper
• mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting

  2007cited by this paper
• Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve.

  2007cited by this paper
• Spinal nerve lesion alters blood–spinal cord barrier function and activates astrocytes in the rat

  2006cited by this paper
• P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin.

  2006cited by this paper
• The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells.

  2006cited by this paper
• Mouse syngenic in vitro blood–brain barrier model: a new tool to examine inflammatory events in cerebral endothelium

  2005cited by this paper
• Role of the Immune system in chronic pain

  2005cited by this paper
• Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts

  2004cited by this paper
• The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation

  2004cited by this paper
• The Cytoplasmic Tails of Claudins Can Influence Tight Junction Barrier Properties through Effects on Protein Stability

  2004cited by this paper
• Loss and recovery of the blood-nerve barrier in the rat sciatic nerve after crush injury are associated with expression of intercellular junctional proteins.

  2003cited by this paper
• Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme

  2003cited by this paper
• Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells

  2002cited by this paper
• Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers.

  2001cited by this paper
• Complex phenotype of mice lacking occludin, a component of tight junction strands.

  2000cited by this paper
• Spared nerve injury: an animal model of persistent peripheral neuropathic pain

  2000cited by this paper
• Ethical guidelines for investigations of experimental pain in conscious animals.

  1983cited by this paper

• When Barriers Break: Tight Junction Regulation and Dynamic Alterations of Barrier Integrity in Neurological Injury

  2026influential citation
• Single-cell RNA sequencing analysis of bone cancer pain model induced by Lewis lung cancer cells in male mice.

  2026cites this paper
• The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice.

  2025cites this paper
• Restoring brain barriers: an innovative approach for treating neurological disorders

  2025cites this paper
• Neurovascular dynamics in the spinal cord from development to pathophysiology.

  2025cites this paper
• Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

  2025cites this paper
• Pericytes and Diabetic Microangiopathies: Tissue Resident Mesenchymal Stem Cells with High Plasticity and Regenerative Capacity

  2025influential citation
• Blocking the p38 MAPK Signaling Pathway in the Rat Hippocampus Alleviates the Depressive-like Behavior Induced by Spinal Cord Injury.

  2025cites this paper
• Transcranial magnetic stimulation through attenuating blood-spinal cord barrier disruption and reducing inflammatory response to improve motor function in rats with spinal cord injury.

  2025cites this paper
• The role of neuroinflammation and impairment of the blood-spinal cord barrier in pathogenesis of amyotrophic lateral sclerosis

  2025cites this paper
• Blocking brown adipocyte β3-adrenoceptor attenuates blood-spinal cord barrier impairment and chronic postsurgical pain in a rat model of preoperative stress.

  2024cites this paper
• Mechanistic insights into “Three Methods and Three Acupoints” Tuina therapy for improving spinal microcirculation and motor function in sciatic nerve injury model rats

  2024cites this paper
• Irisflorentin improves functional recovery after spinal cord injury by protecting the blood-spinal cord barrier and promoting axonal growth.

  2024cites this paper
• Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway.

  2024cites this paper
• Serum Zonulin, Claudin-5, junction Adhesion Molecule-A, Occludin and Tricellulin levels in children with autism spectrum disorder

  2024cites this paper
• 3, 3'-diindolylmethane enhances macrophage efferocytosis and subsequently relieves visceral pain via the AhR/Nrf2/Arg-1-mediated arginine metabolism pathway.

  2023cites this paper
• Lumbosacral spinal proteomic changes during PAR4-induced persistent bladder pain.

  2023cites this paper
• Treg cells-derived exosomes promote blood-spinal cord barrier repair and motor function recovery after spinal cord injury by delivering miR-2861

  2023cites this paper
• Asiaticoside Attenuates Blood–Spinal Cord Barrier Disruption by Inhibiting Endoplasmic Reticulum Stress in Pericytes After Spinal Cord Injury

  2023cites this paper
• M2 macrophage polarization: a potential target in pain relief

  2023influential citation
• Inhibition of autophagy and RIP1/RIP3/MLKL-mediated necroptosis by edaravone attenuates blood spinal cord barrier disruption following spinal cord injury.

  2023cites this paper
• Stabilizing the neural barrier - A novel approach in pain therapy.

  2023cites this paper
• An inhibitor of claudin-5 interactions, M01, alleviates neuroinflammation and vasogenic edema after blood–spinal cord barrier dysfunction

  2023cites this paper
• Role of the blood-spinal cord barrier: An adheren junction regulation mechanism that promotes chronic postsurgical pain.

  2023cites this paper
• Unbiased analysis of the dorsal root ganglion after peripheral nerve injury: no neuronal loss, no gliosis, but satellite glial cell plasticity

  2022cites this paper
• Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction

  2022cites this paper
• The consequence of endothelial remodelling on the blood spinal cord barrier and nociception

  2022cites this paper
• Progression in translational research on spinal cord injury based on microenvironment imbalance

  2022cites this paper
• Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway.

  2022cites this paper
• Domino reaction of neurovascular unit in neuropathic pain after spinal cord injury.

  2022cites this paper
• Changes in blood–spinal cord barrier permeability and neuroimmune interactions in the underlying mechanisms of chronic pain

  2021cites this paper
• Blood-Spinal Cord Barrier: Its Role in Spinal Disorders and Emerging Therapeutic Strategies

  2021influential citation
• The ROCK inhibitor Y-27632 ameliorates blood-spinal cord barrier disruption by reducing tight junction protein degradation via the MYPT1-MLC2 pathway after spinal cord injury in rats.

  2021cites this paper
• Netrin-1 as a Multitarget Barrier Stabilizer in the Peripheral Nerve after Injury

  2021cites this paper
• Neuroimmunological complications arising from chemotherapy‐induced gut toxicity and opioid exposure in female dark agouti rats

  2021cites this paper
• Patchouli Alcohol Improves the Integrity of the Blood-Spinal Cord Barrier by Inhibiting Endoplasmic Reticulum Stress Through the Akt/CHOP/Caspase-3 Pathway Following Spinal Cord Injury

  2021cites this paper
• Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy

  2021cites this paper
• FDA-approved 5-HT1F receptor agonist lasmiditan induces mitochondrial biogenesis and enhances locomotor and blood-spinal cord barrier recovery after spinal cord injury.

  2021cites this paper
• Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination

  2020cites this paper
• Sodium Tanshinone IIA Silate Exerts Microcirculation Protective Effects against Spinal Cord Injury In Vitro and In Vivo

  2020cites this paper
• Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders.

  2020cites this paper
• Antinociceptive modulation by the adhesion-GPCR CIRL promotes mechanosensory signal discrimination

  2020influential citation
• Pericytes Act as Key Players in Spinal Cord Injury.

  2019cites this paper
• Effect of mirabegron on tight junction molecules in primary cultured rat Sertoli cells

  2019cites this paper
• Regional Differences in Tight Junction Protein Expression in the Blood–DRG Barrier and Their Alterations after Nerve Traumatic Injury in Rats

  2019cites this paper
• Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury

  2019cites this paper
• Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target

  2019cites this paper
• Claudin-12 deficiency causes nerve barrier breakdown, mechanical hypersensitivity and painfulness in polyneuropathy

  2019cites this paper
• Central VEGF-A pathway plays a key role in the development of trigeminal neuropathic pain in rats

  2019cites this paper
• Engaging pain fibers after a spinal cord injury fosters hemorrhage and expands the area of secondary injury

  2019cites this paper
• What is normal trauma healing and what is complex regional pain syndrome I? An analysis of clinical and experimental biomarkers.

  2019cites this paper
• Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of microRNA-155-5p in male rats.

  2019cites this paper
• Adenovirus-delivered GFP-HO-1C[INCREMENT]23 attenuates blood–spinal cord barrier permeability after rat spinal cord contusion

  2018cites this paper
• A role for pericytes in chronic pain?

  2018cites this paper
• Quantitative and Microstructural Changes of the Blood-Nerve Barrier in Peripheral Neuropathy

  2018cites this paper
• The physiological functions of central nervous system pericytes and a potential role in pain

  2018cites this paper
• REVIEW Pericytes Act as Key Players in Spinal Cord Injury

  year unknowncites this paper
• Fluids and Barriers of the CNS

  year unknowncites this paper
• Роль нейровоспаления и нарушения гематоспинального барьера в патогенезе бокового амиотрофического склероза

  year unknowncites this paper