Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  American Journal of Physiology - Lung cellular and Molecular Physiology

• Publication date

  2014-04-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1152/ajplung.00243.2013PMID 24508728PMCID PMC3989723
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Roles of Rho/Rock signaling pathway in silica-induced epithelial-mesenchymal transition in human bronchial epithelial cells.

  2013cited by this paper
• Noncovalenly PEGylated CTGF siRNA/PDMAEMA complex for pulmonary treatment of bleomycin-induced lung fibrosis.

  2013cited by this paper
• Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis‐associated epithelial‐to‐mesenchymal transitions

  2013cited by this paper
• Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro

  2013cited by this paper
• Surfactant protein-C chromatin-bound green fluorescence protein reporter mice reveal heterogeneity of surfactant protein C-expressing lung cells.

  2013cited by this paper
• Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis.

  2013cited by this paper
• Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins.

  2013influential reference
• Foxm1 transcription factor is required for lung fibrosis and epithelial‐to‐mesenchymal transition

  2013cited by this paper
• PKCδ as a regulator for TGF-β-stimulated connective tissue growth factor production in human hepatocarcinoma (HepG2) cells.

  2013cited by this paper
• CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis

  2012cited by this paper
• Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues.

  2012cited by this paper
• Ligand‐independent transforming growth factor‐β type I receptor signalling mediates type I collagen‐induced epithelial–mesenchymal transition

  2012cited by this paper
• Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis.

  2011cited by this paper
• Pulmonary microvascular endothelial cells from bleomycin‐induced rats promote the transformation and collagen synthesis of fibroblasts

  2011cited by this paper
• Epithelial progenitor cells in lung development, maintenance, repair, and disease.

  2011cited by this paper
• Epithelial-mesenchymal interactions in pulmonary fibrosis.

  2011cited by this paper
• Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

  2011cited by this paper
• Hepatocyte-Derived Snail1 Propagates Liver Fibrosis Progression

  2011cited by this paper
• Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice.

  2010cited by this paper
• Hepatocytes do not undergo epithelial‐mesenchymal transition in liver fibrosis in mice

  2010cited by this paper
• Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.

  2010cited by this paper
• Guiding Epithelial Cell Phenotypes with Engineered Integrin-Specific Recombinant Fibronectin Fragments

  2010cited by this paper
• Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis.

  2010cited by this paper
• Linking cell structure to gene regulation: signaling events and expression controls on the model genes PAI-1 and CTGF.

  2010cited by this paper
• The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice.

  2010cited by this paper
• Resolved: EMT produces fibroblasts in the kidney.

  2010cited by this paper
• Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis.

  2009cited by this paper
• Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

  2009cited by this paper
• Transforming Growth Factor-β1 (TGFβ1) Stimulates Connective Tissue Growth Factor (CCN2/CTGF) Expression in Human Gingival Fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent Mechanism

  2008cited by this paper
• Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis.

  2008cited by this paper
• Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

  2008cited by this paper
• Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

  2008cited by this paper
• Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.

  2008cited by this paper
• Connective tissue growth factor promoter activity in normal and wounded skin

  2008cited by this paper
• Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.

  2008cited by this paper
• Enhanced myofibroblastic differentiation and survival in Thy-1(-) lung fibroblasts.

  2007cited by this paper
• Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition*

  2007cited by this paper
• Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

  2007cited by this paper
• Actin-dependent regulation of connective tissue growth factor.

  2007cited by this paper
• Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

  2006cited by this paper
• Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers.

  2006cited by this paper
• Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

  2006influential reference
• Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

  2006cited by this paper
• RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation.

  2005cited by this paper
• Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

  2005cited by this paper
• Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.

  2004cited by this paper
• Impact of Basic Research on Tomorrow's MedicineThe Role of Transforming Growth Factor β in Lung Development and Disease

  2004cited by this paper
• Mechanisms of pulmonary fibrosis.

  2004cited by this paper
• Bone marrow-derived progenitor cells in pulmonary fibrosis.

  2004cited by this paper
• Identification of Circulating Fibrocytes as Precursors of Bronchial Myofibroblasts in Asthma1

  2003cited by this paper
• The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology.

  2003cited by this paper
• Smad-dependent and Smad-independent pathways in TGF-beta family signalling.

  2003influential reference
• Smad-dependent and Smad-independent pathways in TGF-β family signalling

  2003cited by this paper
• American thoracic society/European respiratory society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias

  2002cited by this paper
• ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias

  2002cited by this paper
• Evidence that fibroblasts derive from epithelium during tissue fibrosis.

  2002cited by this paper
• Maintenance of the mouse type II cell phenotype in vitro.

  2002cited by this paper
• Early restriction of peripheral and proximal cell lineages during formation of the lung

  2002cited by this paper
• American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors

  2002cited by this paper
• Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

  2001cited by this paper
• The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts

  2001cited by this paper
• Contribution of small GTPase Rho and its target protein rock in a murine model of lung fibrosis.

  2001cited by this paper
• Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF.

  2001cited by this paper
• Differential expression, surface binding, and response to connective tissue growth factor in lung fibroblast subpopulations.

  2001cited by this paper
• Transforming growth factor-&bgr; and connective tissue growth factor: key cytokines in scleroderma pathogenesis

  2001cited by this paper
• Idiopathic pulmonary fibrosis: Diagnosis and treatment: International Consensus Statement

  2000cited by this paper
• American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS).

  2000cited by this paper
• Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair

  1994cited by this paper

• Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets

  2025cites this paper
• PI3K/Akt in IPF: untangling fibrosis and charting therapies

  2025cites this paper
• Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures

  2024cites this paper
• Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis

  2024cites this paper
• Antifibrotic Drugs against Idiopathic Pulmonary Fibrosis and Pulmonary Fibrosis Induced by COVID-19: Therapeutic Approaches and Potential Diagnostic Biomarkers

  2024cites this paper
• Circulating MicroRNAs in Idiopathic Pulmonary Fibrosis: A Narrative Review

  2024cites this paper
• Nitazoxanide alleviates experimental pulmonary fibrosis by inhibiting the development of cellular senescence.

  2024cites this paper
• TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2

  2023cites this paper
• Therapeutic strategies to target connective tissue growth factor in fibrotic lung diseases.

  2023cites this paper
• CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid

  2023cites this paper
• Inhibition of Discoidin Domain Receptor 2 Reveals Kinase Dependent and Kinase Independent Functions in Regulating Fibroblast Activity.

  2023cites this paper
• Nrf2 Is Involved in Hyperglycemia-Induced Abnormal Lung Development Through Both Antioxidation-Dependent and Antioxidation-Independent Activation.

  2023cites this paper
• A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung

  2023cites this paper
• Mesenchymal Cells in The Lung: Evolving Concepts and Their Role in Fibrosis.

  2023cites this paper
• THE TRANSLATIONAL POSSIBILITY OF TARGETING LncRNAs AS A THERAPEUTIC STRATEGY FOR IDIOPATHIC PULMONARY FIBROSIS

  2022cites this paper
• Molecular pathways and role of epigenetics in the idiopathic pulmonary fibrosis.

  2022cites this paper
• The matricellular protein CCN3 supports lung endothelial homeostasis and function.

  2022cites this paper
• Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge

  2022cites this paper
• Targeting Histone Deacetylases in Idiopathic Pulmonary Fibrosis: A Future Therapeutic Option

  2022cites this paper
• Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury

  2022cites this paper
• Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications

  2021cites this paper
• Role of various imbalances centered on alveolar epithelial cell/fibroblast apoptosis imbalance in the pathogenesis of idiopathic pulmonary fibrosis

  2021cites this paper
• Precision medicine in idiopathic pulmonary fibrosis therapy: From translational research to patient-centered care.

  2021cites this paper
• Type I Collagen Signaling Regulates Opposing Fibrotic Pathways through Alpha2Beta1 Integrin.

  2020cites this paper
• Lung tissue extracellular matrix‐derived hydrogels protect against radiation‐induced lung injury by suppressing epithelial–mesenchymal transition

  2020cites this paper
• Diverse Injury Pathways Induce Alveolar Epithelial Cell CCL2/12 Which Promotes Lung Fibrosis.

  2020cites this paper
• Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model

  2020cites this paper
• Bleomycin induced apical-basal polarity loss in alveolar epithelial cell contributes to experimental pulmonary fibrosis.

  2020cites this paper
• The extracellular matrix and mechanotransduction in pulmonary fibrosis.

  2020cites this paper
• You Say You Want a Resolution (of Fibrosis).

  2020cites this paper
• Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts

  2020cites this paper
• Inhibitory effects of msFGFR2c on the epithelial-to-mesenchymal transition of AE2 cells in pulmonary fibrosis

  2020cites this paper
• Pulmonary fibrosis: a disease of alveolar collapse and collagen deposition

  2019cites this paper
• HDAC8 inhibition ameliorates pulmonary fibrosis.

  2019influential citation
• Mechanisms for the Resolution of Organ Fibrosis.

  2019cites this paper
• Pharmacotherapy and adjunctive treatment for idiopathic pulmonary fibrosis (IPF).

  2019cites this paper
• Joint Transcriptomic Analysis of Lung Cancer and Other Lung Diseases

  2019cites this paper
• RESEARCH ARTICLE Biomarkers in Lung Diseases: From Pathogenesis to Prediction to New Therapies TGF- (cid:2) 1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a c-Jun NH 2 -terminal kinase-1-dependent manner

  2018cites this paper
• Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells

  2018cites this paper
• Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling

  2018cites this paper
• IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells

  2018cites this paper
• Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model

  2018cites this paper
• Negative impact of hyperglycaemia on mouse alveolar development

  2018cites this paper
• The A2B Adenosine Receptor Modulates the Epithelial– Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells

  2018cites this paper
• Investigating the role of CCN2 in a bleomycin model of Idiopathic Pulmonary Fibrosis

  2018cites this paper
• Therapeutic targets and early stage clinical trials for pulmonary fibrosis

  2018cites this paper
• SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice.

  2018cites this paper
• Caractérisation et généralisation de l’implication de la voie NOTCH cytoplasmique au cours des processus de transition épithélio-mésenchymateuse chez l’embryon de poulet

  2018cites this paper
• TGF-β1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a c-Jun NH2-terminal kinase-1-dependent manner.

  2018cites this paper
• New therapeutics based on emerging concepts in pulmonary fibrosis

  2018cites this paper
• Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis

  2018cites this paper
• Causes of Pulmonary Fibrosis in the Elderly

  2018cites this paper
• Discoidin Domain Receptor 2 Signaling Regulates Fibroblast Apoptosis through PDK1/Akt

  2018cites this paper
• Fibrotic Signaling in the Lung

  2018cites this paper
• Fibroblast growth factors and pulmonary fibrosis: it's more complex than it sounds

  2017cites this paper
• The Function of Epithelial Cells in Pulmonary Fibrosis

  2017cites this paper
• The Role of Epithelial Cell Quality Control in Health and Disease of the Distal Lung

  2017cites this paper
• Plasma membrane wounding and repair in pulmonary diseases.

  2017cites this paper
• Therapeutic targets in idiopathic pulmonary fibrosis.

  2017cites this paper
• Tissue remodelling in pulmonary fibrosis

  2017cites this paper
• The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis

  2017cites this paper
• Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis

  2017cites this paper
• CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis

  2016cites this paper
• Increased Epithelial Expression of CTGF and S100A7 with Elevated Subepithelial Expression of IL-1β in Trachomatous Trichiasis

  2016cites this paper
• Regulatory mechanisms of TGF‐β1‐induced fibrogenesis of human alveolar epithelial cells

  2016cites this paper
• Transcriptional and posttranscriptional regulation of CXCL8/IL-8 gene expression induced by connective tissue growth factor

  2016cites this paper
• Biomarkers in Lung Diseases : from Pathogenesis to Prediction to New Therapies Epithelial disruption of Gab 1 perturbs surfactant homeostasis and predisposes mice to lung injuries

  2016cites this paper
• Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis

  2016cites this paper
• Sunitinib, a Small-Molecule Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice.

  2016cites this paper
• Fibroblast Growth Factors and Pulmonary Fibrosis : It ’ s more complex than it sounds † Running Title : Pleiotropic actions of FGFs in lung fibrosis

  2016cites this paper
• Epithelium‐dependent profibrotic milieu in the pathogenesis of idiopathic pulmonary fibrosis: current status and future directions

  2016cites this paper
• Les cellules endothéliales peuvent acquérir un phénotype mésenchymateux associé avec l’expression de la protéine nestine dans un modèle d’hypertrophie cardiaque et de fibrose réactive

  2016cites this paper
• Transcriptional and posttranscriptional regulation of CXCL8/IL-8 gene expression induced by connective tissue growth factor

  2015cites this paper
• The role of endothelial adhesins in leukocyte adhesion in response to pharmaceutical agents that induce pulmonary fibrosis

  2015cites this paper
• Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.

  2015cites this paper
• Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.

  2015cites this paper
• The cytokines of pulmonary fibrosis: Much learned, much more to learn.

  2015cites this paper
• Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition.

  2015cites this paper
• Overexpression of inhibitor of DNA-binding 2 attenuates pulmonary fibrosis through regulation of c-Abl and Twist.

  2015influential citation
• Fibrocytes Are Not an Essential Source of Type I Collagen during Lung Fibrosis

  2014influential citation
• Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage.

  2014cites this paper
• N-acetylcysteine: A promising drug against formaldehyde-induced damage in lung epithelial cells.

  2014cites this paper
• Type I Collagen during Lung Fibrosis Fibrocytes Are Not an Essential Source Of

  year unknowncites this paper