SCIENCE@home

Musanga cecropioides leaf extract exhibits anti-inflammatory and anti-nociceptive activities in animal models

A. Sowemimo,Eboji Okwuchuku,F. M. Samuel,O. Ayoola,Ibrahim Mutiat

Published 2015 in Revista Brasileira de Farmacognosia

ABSTRACT

Extract obtained from the leaves of Musanga cecropioides R. Br. ex Tedlie, Urticaceae, a tree growing in Africa, is used traditionally in the treatment of edema and rheumatism. The anti-inflammatory and antinociceptive properties of ethanol extract were studied using the carrageenan, histamine, serotonin and xylene-induced edema tests as well as the formalin, mouse writhing and tail clip tests. Significant dose dependent inhibition was observed in the carrageenan model with peak inhibition at 150 mg/kg (71.43%, 90 min, p < 0.001). In the histamine and serotonin models, the extract caused significant inhibition of 83.33% ( p < 0.05) and 45% ( p < 0.01) at 120 min respectively. For the xylene model, the extract showed maximum inhibition (59.25%) at 200 mg/kg. Also, M. cecropioides produced significant anti-nociceptive activity in the mouse writhing(55.12%, p < 0.01 ), formalin (81.88%, p < 0.01 ) and tail clip (11.78%, p < 0.001 ) tests at 200 mg/kg respectively. The results obtained in this study demonstrated that the ethanolic leaf extract of M. cecropioides possesses anti-inflammatory effect possibly mediated via histaminergic and serotonergic inhibition and anti-nociceptive effect mediated via peripheral mechanism with mild central involvement.

PUBLICATION RECORD

  • Publication year

    2015

  • Venue

    Revista Brasileira de Farmacognosia

  • Publication date

    2015-09-01

  • Fields of study

    Medicine, Chemistry, Environmental Science

  • Identifiers
    DOI 10.1016/J.BJP.2015.07.022
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-58 of 58 references · Page 1 of 1

CITED BY

Showing 1-22 of 22 citing papers · Page 1 of 1