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Recombinant Human Thyrotropin as an Adjuvant to Radioiodine Therapy for Nontoxic, Nodulal Goiter.

W. Nieuwlaat

Published 2005 in Unknown venue

ABSTRACT

Radioiodine (131I) is increasingly used as treatment for volume reduction of nontoxic, nodular goiter. A high dose of 131I is often needed because of low thyroid radioiodide uptake (RAIU). We investigated whether pretreatment with a single, low dose of recombinant human TSH (rhTSH; Thyrogen, Genzyme Transgenics Corp.) enhances RAIU in 15 patients with nontoxic, nodular goiter (14 women and 1 man; aged 61 ± 11 yr). Four patients were studied twice, and 1 patient was studied 3 times. RAIU was measured both under basal conditions and after pretreatment (im) with rhTSH, given either 2 h (0.01 mg; n = 7) or 24 h [0.01 mg (n = 7) or 0.03 mg (n = 7)] before 131I administration (20–40 μCi). Serum levels of TSH, free T4 (FT4), and total T3 were measured at 2, 5, 8, 24, 48, 72, 96, and 192 h after rhTSH administration. After administration of 0.01 mg rhTSH, serum TSH rose from 0.7 ± 0.5 to a peak level of 4.4 ± 1.1 mU/L (P 20% in 10 and by >30% in 6). In conclusion, pretreatment with a single, low dose of rhTSH in patients with nontoxic, nodular goiter increased RAIU considerably. Our observations hold promise that administration of rhTSH before 131I therapy for nontoxic, nodular goiter will allow treatment with lower doses of 131I in these patients. 2 .1 2.1 72 A dm iniration of a Sngle ow D se of Rcom bant H um an Thytropin Sigficantly Enances Tyroid Radiodide U pake in N otoxic N oular G oiter Proefschrift WA Nieuwlaat H2 23-03-2005 15:13 Pagina 72

PUBLICATION RECORD

  • Publication year

    2005

  • Venue

    Unknown venue

  • Publication date

    Unknown publication date

  • Fields of study

    Medicine

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    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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