SCIENCE@home

Hematopoietic Stem Cells and Response to Interferon

A. Masumi

Published 2013 in Unknown venue

ABSTRACT

Homeostasis in the bone marrow is dependent on the ability of hematopoietic stem cells (HSCs) to self-renew faithfully, differentiate into various lineages of the hematopoietic system, and form blood cells of several types (Figure 1) [1,2]. Under homeostatic conditions, HSCs are thought to be quiescent, and they are referred to as long-term reconstituting HSCs (LT-HSC) or dormant HSCs (dHSCs) [3,4]. Blood and immune cells are produced by the more differen‐ tiated short-term reconstituting HSCs (ST-HSCs) or multipotent progenitors (MPPs). Genetic and molecular studies of HSC self-renewal have identified candidate regulatory factors, in‐ cluding cell-intrinsic regulators, such as transcription factors and cell surface receptors, and cell-extrinsic regulators, such as the bone marrow niche and cytokines. Under certain condi‐ tions, such as inflammatory stress, HSCs differentiate into progenitor cells with less ability to self-renew, and they can be stimulated to divide and/or differentiate into all cell types in the peripheral blood [5,6]. Under inflammatory conditions, such as during bacterial infection or sepsis, an apparent expansion of lineage-negative Sca-1+c-Kit+ bone marrow cells (KSL) has been observed [7–11]. HSCs and progenitor cells are involved in the expansion of KSL; and expansion of the KSL population in the bone marrow has been associated with a loss of dor‐ mant LT-HSCs, reduced engraftment, and a bias towards myeloid lineage differentiation within that population. The process of the transition of HSCs from dormancy to activity is mediated by type I interferon (IFN) and type II IFN.

PUBLICATION RECORD

  • Publication year

    2013

  • Venue

    Unknown venue

  • Publication date

    2013-05-08

  • Fields of study

    Biology, Medicine

  • Identifiers
    DOI 10.5772/54689
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-52 of 52 references · Page 1 of 1

CITED BY