Agonist Activity of the 3‐Hydroxy Metabolites of Tibolone Through the Oestrogen Receptor in the Mouse N20.1 Oligodendrocyte Cell Line and Normal Human Astrocytes

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of neuroendocrinology

• Publication date

  2007-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2826.2007.01611.xPMID 18001325
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Estrogen, cognition and female ageing.

  2007cited by this paper
• Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies.

  2006cited by this paper
• Estrogen receptor‐α is associated with the plasma membrane of astrocytes and coupled to the MAP/Src‐kinase pathway

  2005cited by this paper
• Transcriptional regulation of tyrosine hydroxylase by estrogen: opposite effects with estrogen receptors alpha and beta and interactions with cyclic AMP.

  2005cited by this paper
• Expression of P0 glycoprotein in CNS glia: Effects of overexpression in N20.1 cells

  2005cited by this paper
• Transcriptional regulation of tyrosine hydroxylase by estrogen: opposite effects with estrogen receptors α and β and interactions with cyclic AMP

  2005cited by this paper
• From the authors

  2005cited by this paper
• Activity of estradiol and selective estrogen receptor modulators in the mouse N20.1 oligodendrocyte/astrocytes cell line.

  2005cited by this paper
• From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens.

  2005cited by this paper
• Comparison of in vivo and in vitro subcellular localization of estrogen receptors alpha and beta in oligodendrocytes.

  2004cited by this paper
• Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death.

  2004cited by this paper
• Glia Mediates the Neuroprotective Action of Estradiol on β-Amyloid-Induced Neuronal Death

  2004cited by this paper
• Comparison of in vivo and in vitro subcellular localization of estrogen receptors α and β in oligodendrocytes

  2004cited by this paper
• Neuroprotective effects of estrogen and tamoxifen in vitro

  2003cited by this paper
• Estrogen receptor alpha-immunoreactive astrocytes are increased in the hippocampus in Alzheimer's disease.

  2003cited by this paper
• Estrogen receptor α-immunoreactive astrocytes are increased in the hippocampus in Alzheimer’s disease

  2003cited by this paper
• Differential Expression of Estrogen Receptors Alpha and Beta in the Spinal Cord during Postnatal Development: Localization in Glial Cells

  2003cited by this paper
• Tibolone is not converted by human aromatase to 7alpha-methyl-17alpha-ethynylestradiol (7alpha-MEE): analyses with sensitive bioassays for estrogens and androgens and with LC-MSMS.

  2003cited by this paper
• Tibolone for postmenopausal women: systematic review of randomized trials.

  2002cited by this paper
• Oestrogen as a neuroprotective hormone

  2002cited by this paper
• Estrogen-Astrocyte interactions: Implications for neuroprotection

  2002cited by this paper
• Pros and cons of existing treatment modalities in osteoporosis: a comparison between tibolone, SERMs and estrogen (+/-progestogen) treatments.

  2002cited by this paper
• Glial expression of estrogen and androgen receptors after rat brain injury

  2002cited by this paper
• The anti‐inflammatory activity of estrogen in glial cells is regulated by the PKC‐anchoring protein RACK‐1

  2002cited by this paper
• Estrogens: trophic and protective factors in the adult brain.

  2001cited by this paper
• Hippocampal estrogen beta-receptor immunoreactivity is increased in Alzheimer's disease.

  2001cited by this paper
• Neuroprotection by estradiol.

  2001cited by this paper
• Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain

  2001cited by this paper
• Role of estrogen receptor beta in estrogen action.

  2001cited by this paper
• Effects of Hormone Replacement Therapy on Cognitive and Brain Aging

  2001cited by this paper
• Hippocampal estrogen β-receptor immunoreactivity is increased in Alzheimer’s disease

  2001cited by this paper
• Reduced cerebrospinal fluid estradiol levels are associated with increased beta-amyloid levels in female patients with Alzheimer's disease.

  2001cited by this paper
• Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease.

  2000cited by this paper
• Estrogen-Astrocyte-Luteinizing Hormone-Releasing Hormone Signaling: A Rolefor Transforming Growth Factor-β11

  2000cited by this paper
• Histochemical and electrophysiological evidence for estrogen receptors on cultured astrocytes: colocalization with cholinergic receptors

  2000cited by this paper
• Effect of estradiol on neuronal Swedish-mutated beta-amyloid precursor protein metabolism: reversal by astrocytic cells.

  2000cited by this paper
• Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory

  2000cited by this paper
• Gonadal Steroids Promote Glial Differentiation and Alter Neuronal Morphology in the Developing Hypothalamus in a Regionally Specific Manner

  1999cited by this paper
• Increased intracellular calcium alters myelin gene expression in the N20.1 oligodendroglial cell line

  1999cited by this paper
• Localization of estrogen receptor β‐immunoreactivity in astrocytes of the adult rat brain

  1999cited by this paper
• The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions.

  1999cited by this paper
• Role of astroglia in estrogen regulation of synaptic plasticity and brain repair.

  1999cited by this paper
• Estrogen and the developing mammalian brain

  1999cited by this paper
• Livial: a review of clinical studies.

  1999cited by this paper
• Estrogen actions in the central nervous system.

  1999cited by this paper
• Effects of Cyclic AMP on Expression of Myelin Genes in the N20.1 Oligodendroglial Cell Line

  1998cited by this paper
• The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro.

  1998cited by this paper
• Bidirectional transcription regulation of glial fibrillary acidic protein by estradiol in vivo and in vitro.

  1998cited by this paper
• Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites.

  1997cited by this paper
• Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

  1996cited by this paper
• Estrogen replacement therapy and risk of Alzheimer disease.

  1996cited by this paper
• Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.

  1995cited by this paper
• Gonadal hormone regulation of insulin-like growth factor-I-like immunoreactivity in hypothalamic astroglia of developing and adult rats.

  1994cited by this paper
• The US economic and social costs of Alzheimer's disease revisited.

  1994cited by this paper
• Expression of Myelin Protein Genes and Other Myelin Components in an Oligodendrocytic Cell Line Conditionally Immortalized with a Temperature‐Sensitive Retrovirus

  1993cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• A Plea for Exploration in Suspected Malignant Disease of the Ovary, with Illustrative Cases.

  1904cited by this paper

• Tibolone Improves Motor Recovery and Regulates Neuroinflammation and Gliosis in a Model of Traumatic Spinal Cord Injury

  2025cites this paper
• Network pharmacology and topological analysis on tibolone metabolites and their molecular mechanisms in traumatic brain injury.

  2023cites this paper
• Network pharmacology identifies IL6 as an important hub and target of tibolone for drug repurposing in traumatic brain injury.

  2021cites this paper
• The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge

  2020cites this paper
• Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions

  2020cites this paper
• Hormones and Steroids as Neurotransmitters

  2020cites this paper
• Tibolone as Hormonal Therapy and Neuroprotective Agent.

  2020cites this paper
• Effects of estrogens and androgens on mitochondria under normal and pathological conditions

  2019influential citation
• Neuroactive steroids, neurosteroidogenesis and sex

  2019cites this paper
• Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells.

  2019cites this paper
• TERT inhibition leads to reduction of IL‐6 expression induced by palmitic acid and interferes with the protective effects of tibolone in an astrocytic cell model

  2019cites this paper
• The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury

  2018cites this paper
• Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta

  2017cites this paper
• Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches

  2017cites this paper
• Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid

  2017cites this paper
• Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system.

  2016cites this paper
• Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions.

  2016cites this paper
• Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression.

  2016cites this paper
• Neuroprotection by Exogenous Estrogenic Compounds Following Traumatic Brain Injury

  2015cites this paper
• Tibolone protects T98G cells from glucose deprivation.

  2014cites this paper