Effects of the Soybean Flour Diet on Insulin Secretion and Action

Publisher Summary Soybean is an important plant for human and animal nutrition due to its large amounts of protein, lipid, carbohydrates, minerals, vitamins, and fiber. Because of its reduced cost and elevated nutritional value, soybean flour has been used as alternative feed in the recovery of nutritional status. Part of the beneficial effects of soybean and by-products has been associated with their effects on insulin secretion and action. Insulin is an anabolic, polypeptide hormone synthesized by pancreatic β-cells, whose synthesis is activated by an increase of nutrients, especially glucose. Insulin acts on several periphery tissues, including liver, muscle, and adipose tissue. In rats, soybean flour diet activates the β-cell cAMP/PKA pathway, increasing insulin secretion in response to glucose, and decreases relative weight of fat deposits and even reduces the energetic expenditure without alterations in food intake. Soybean diet interferes in various steps of the insulin signaling pathway. Muscle insulin-reduced phosphorylation of GSK-3 is improved by soy proteins and isoflavones, partially preventing deleterious effects of fat feeding.

• Publication year

  2019

• Venue

  Flour and Breads and their Fortification in Health and Disease Prevention

• Publication date

  Unknown publication date

• Fields of study

  Agricultural and Food Sciences, Medicine, Biology

• Identifiers
  DOI 10.1016/B978-0-12-380886-8.10045-5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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