Functional characterisation of mycobacterial DNA gyrase: an efficient decatenase.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nucleic Acids Research

• Publication date

  2002-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/NAR/30.10.2144PMID 12000834PMCID PMC115291
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Topoisomerase IV, alone, unknots DNA in E. coli.

  2001cited by this paper
• Effect of different classes of inhibitors on DNA gyrase from Mycobacterium smegmatis.

  2001cited by this paper
• Monoclonal antibodies to mycobacterial DNA gyrase A inhibit DNA supercoiling activity.

  2001influential reference
• DNA topoisomerases: structure, function, and mechanism.

  2001cited by this paper
• A Mycobacterium smegmatis gyrase B specific monoclonal antibody reveals association of gyrase A and B subunits in the cell.

  2001influential reference
• Suppression of chromosome segregation defects of Escherichia coli muk mutants by mutations in topoisomerase I.

  2000cited by this paper
• Closing the ring: links between SMC proteins and chromosome partitioning, condensation, and supercoiling.

  2000cited by this paper
• The Additional 165 Amino Acids in the B Protein ofEscherichia coli DNA Gyrase Have an Important Role in DNA Binding*

  2000influential reference
• Structural heterogeneity in DNA gyrases from Gram-positive and Gram-negative bacteria.

  2000cited by this paper
• Intracellular targets of moxifloxacin: a comparison with other fluoroquinolones.

  2000cited by this paper
• Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays.

  2000cited by this paper
• Activity of moxifloxacin against mycobacteria.

  1999cited by this paper
• The DNA Gyrase-Quinolone Complex

  1998cited by this paper
• In vitro activity of BAY 12-8039, a new fluoroquinolone

  1997cited by this paper
• Probing the role of the ATP-operated clamp in the strand-passage reaction of DNA gyrase.

  1996cited by this paper
• Mutations in the B Subunit of Escherichia coli DNA Gyrase That Affect ATP-dependent Reactions (*)

  1996cited by this paper
• Contrasting Enzymatic Activities of Topoisomerase IV and DNA Gyrase from Escherichia coli*

  1996cited by this paper
• Mycobacterium smegmatis DNA gyrase: cloning and overexpression in Escherichia coli.

  1995cited by this paper
• Topoisomerase IV is a target of quinolones in Escherichia coli.

  1995cited by this paper
• Mycobacterial DNA gyrase: enzyme purification and characterization of supercoiling activity.

  1995cited by this paper
• Sequences of conserved region in the A subunit of DNA gyrase from nine species of the genus Mycobacterium: phylogenetic analysis and implication for intrinsic susceptibility to quinolones

  1995cited by this paper
• Appendix. II: Alignment of primary sequences of DNA topoisomerases.

  1994cited by this paper
• A simple modification of Blum's silver stain method allows for 30 minute detection of proteins in polyacrylamide gels.

  1994cited by this paper
• Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions.

  1993cited by this paper
• The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

  1993cited by this paper
• DNA gyrase: structure and function.

  1991cited by this paper
• Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

  1990cited by this paper
• Peptide sequencing and site‐directed mutagenesis identify tyrosine‐319 as the active site tyrosine of Escherichia coli DNA topoisomerase I

  1989cited by this paper
• DNA gyrase-catalyzed decatenation of multiply linked DNA dimers.

  1987cited by this paper
• Deoxyribonucleic acid replication time in Mycobacterium tuberculosis H37 Rv

  1986cited by this paper
• Manipulation of intracellular magnesium content in polymyxin B nonapeptide-sensitized Escherichia coli by ionophore A23187

  1985cited by this paper
• The DNA dependence of the ATPase activity of DNA gyrase.

  1984cited by this paper
• Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase.

  1984cited by this paper
• The binding of gyrase to DNA: analysis by retention by nitrocellulose filters.

  1982influential reference
• Site-specific interaction of DNA gyrase with DNA.

  1981influential reference
• DNA gyrase: affinity chromatography on novobiocin-Sepharose and catalytic properties.

  1981influential reference
• The intrinsic ATPase of DNA gyrase.

  1980cited by this paper
• Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers.

  1980cited by this paper
• Requirement for calcium ions in mycobacteriophage I3 DNA injection and propagation

  1980influential reference
• Formation and resolution of DNA catenanes by DNA gyrase.

  1980cited by this paper
• DNA gyrase: subunit structure and ATPase activity of the purified enzyme.

  1978cited by this paper
• Purification of subunits of Escherichia coli DNA gyrase and reconstitution of enzymatic activity.

  1978cited by this paper
• Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.

  1977cited by this paper
• DNA gyrase: an enzyme that introduces superhelical turns into DNA.

  1976cited by this paper

• Enzyme–DNA Interactions Affect the Catalytic Inhibition of Mycobacterial Gyrases by Antibacterial Drugs

  2026cites this paper
• Succinylation of GyrB Is a Mechanism Conferring Fluoroquinolone Resistance.

  2025cites this paper
• Multifunctional Mycobacterial Topoisomerases with Distinctive Features.

  2025cites this paper
• Different propensities for gate opening in gyrases and topoisomerase IV

  2025cites this paper
• Type VII secretion system deploys an active iron uptake pathway to enhance bacterial fitness and counteract host nutritional immunity

  2025cites this paper
• Indole-containing inhibitors with improved efficacy targeting the gyrase of Mycobacterium tuberculosis

  2024cites this paper
• Single-molecule dynamics of DNA gyrase in evolutionarily distant bacteria Mycobacterium tuberculosis and Escherichia coli

  2023cites this paper
• Elucidating specific interactions for designing novel pyrrolamide derivatives as potential GyrB inhibitors based on ab initio fragment molecular orbital calculations

  2023cites this paper
• Distinct subunit architecture and assembly pattern of DNA gyrase from mycobacteria

  2023cites this paper
• An in silico evaluation of anthraquinone derivatives as potential inhibitors of DNA gyrase B of Mycobacterium tuberculosis

  2022cites this paper
• An In-Silico Evaluation of Anthraquinones as Potential Inhibitors of DNA Gyrase B of Mycobacterium tuberculosis

  2022cites this paper
• Topoisomerase VI is a chirally-selective, preferential DNA decatenase

  2021cites this paper
• Identification of Gip as a novel phage-encoded gyrase inhibitor protein featuring a broad activity profile

  2021cites this paper
• What makes a type IIA topoisomerase a gyrase or a Topo IV?

  2021cites this paper
• The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic

  2021influential citation
• Diversity and Functions of Type II Topoisomerases

  2021cites this paper
• Identification of Gip as a novel phage‐encoded gyrase inhibitor protein of Corynebacterium glutamicum

  2021cites this paper
• Nano-enabled strategies to combat methicillin-resistant Staphylococcus aureus.

  2021cites this paper
• Role of unique loops in oligomerization and ATPase function of Plasmodium falciparum gyrase B

  2021cites this paper
• Mapping DNA Topoisomerase Binding and Cleavage Genome Wide Using Next-Generation Sequencing Techniques

  2020cites this paper
• Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase

  2020cites this paper
• ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis

  2020cites this paper
• Functional interactions between gyrase subunits are optimized in a species-specific manner

  2020cites this paper
• Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole.

  2018cites this paper
• Recent progress in the discovery and development of DNA gyrase B inhibitors.

  2018cites this paper
• Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis

  2018cites this paper
• The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.

  2018cites this paper
• Rewired Downregulation of DNA Gyrase Impacts Cell Division, Expression of Topology Modulators, and Transcription in Mycobacterium smegmatis.

  2018cites this paper
• Studies on DNA gyrase of quinolone-resistant Mycobacterium leprae [an abstract of dissertation and a summary of dissertation review]. 論文内容の要旨

  2018cites this paper
• Genome-wide mapping of Topoisomerase I activity sites reveal its role in chromosome segregation

  2018cites this paper
• DNA topoisomerase I and DNA gyrase as targets for TB therapy.

  2017cites this paper
• LCMS-based proteomic analysis of susceptible Musa-Meloidogyne incognita interaction and characterisation of partial NBS-LRR resistance gene in Musa acuminata spp. / Mohamad Taufiq Ahmad

  2017cites this paper
• DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens

  2017cites this paper
• Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase

  2017cites this paper
• DNA Gyrase of Deinococcus radiodurans is characterized as Type II bacterial topoisomerase and its activity is differentially regulated by PprA in vitro

  2016cites this paper
• PprA Protein Is Involved in Chromosome Segregation via Its Physical and Functional Interaction with DNA Gyrase in Irradiated Deinococcus radiodurans Bacteria

  2016cites this paper
• Functional Analyses of the Toxoplasma gondii DNA Gyrase Holoenzyme: A Janus Topoisomerase with Supercoiling and Decatenation Abilities

  2015cites this paper
• E. coli Gyrase Fails to Negatively Supercoil Diaminopurine-Substituted DNA.

  2015cites this paper
• Assays, Surrogates, and Alternative Technologies for a TB Lead Identification Program Targeting DNA Gyrase ATPase

  2015cites this paper
• Quinolone resistance acquisition and impact on virulence in Salmonella enterica: a cost-benefit matter

  2015cites this paper
• Targeting Mycobacterium tuberculosis Topoisomerase I by Small-Molecule Inhibitors

  2014cites this paper
• Direct regulation of topoisomerase activity by a nucleoid-associated protein

  2014cites this paper
• Molecular Basis for the Differential Quinolone Susceptibility of Mycobacterial DNA Gyrase

  2014cites this paper
• Unique features of apicoplast DNA gyrases from Toxoplasma gondii and Plasmodium falciparum

  2014influential citation
• HupB, a Nucleoid-Associated Protein of Mycobacterium tuberculosis, Is Modified by Serine/Threonine Protein Kinases In Vivo

  2014cites this paper
• Nagaraja Protein of Mycobacterium tuberculosis Membrane-Anchored Nucleoid-Associated Motility , and Biofilm Formation by a Regulation of Lipid Biosynthesis , Sliding

  2013cites this paper
• Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes.

  2013cites this paper
• BACTERIAL DNA GYRASE IS NOT THE TARGET OF QUINOLINE - BASED ANTI - TUBERCU LOSIS COMPOUNDS

  2013cites this paper
• Regulation of Lipid Biosynthesis, Sliding Motility, and Biofilm Formation by a Membrane-Anchored Nucleoid-Associated Protein of Mycobacterium tuberculosis

  2013cites this paper
• Topoisomerase IV is required for partitioning of circular chromosomes but not linear chromosomes in Streptomyces

  2013cites this paper
• Exploration of fluoroquinolone resistance in Streptococcus pyogenes: comparative structure analysis of wild‐type and mutant DNA gyrase

  2013cites this paper
• Xer Recombinase and Genome Integrity in Helicobacter pylori, a Pathogen without Topoisomerase IV

  2012cites this paper
• The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action

  2012cites this paper
• Chemistry and biology of DNA-binding small molecules

  2012cites this paper
• Correction: Xer Recombinase and Genome Integrity in Helicobacter pylori, a Pathogen without Topoisomerase IV

  2012cites this paper
• Understanding Substrate Selection and Functional Output of Bacterial Type IIA Topoisomerase Orthologs and Paralogs

  2012cites this paper
• Binding of two DNA molecules by type II topoisomerases for decatenation

  2012influential citation
• The role of Ca2+ in the activity of Mycobacterium tuberculosis DNA gyrase

  2012cites this paper
• In front of and behind the replication fork: bacterial type IIA topoisomerases

  2010cites this paper
• A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs

  2010cites this paper
• Antimycobacterial activities of novel fluoroquinolones.

  2009cites this paper
• Synthesis and in‐vitro Antimycobacterial Evaluation of 1‐(Cyclopropyl/2,4‐difluorophenyl/tert‐butyl)‐1,4‐dihydro‐ 8‐methyl‐6‐nitro‐4‐oxo‐7‐(substituted secondary amino)quinoline‐3‐carboxylic acids

  2009cites this paper
• Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids.

  2009cites this paper
• Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme.

  2008cites this paper
• Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids.

  2008cites this paper
• The Pentapeptide Repeat Proteins MfpAMt and QnrB4 Exhibit Opposite Effects on DNA Gyrase Catalytic Reactions and on the Ternary Gyrase-DNA-Quinolone Complex

  2008cites this paper
• Mechanism of action of and resistance to quinolones

  2008cites this paper
• Antimycobacterial and phototoxic evaluation of novel 6-fluoro/nitro-4-oxo-7-(sub)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid.

  2008cites this paper
• Novel ofloxacin derivatives: synthesis, antimycobacterial and toxicological evaluation.

  2008cites this paper
• Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid.

  2008cites this paper
• Synthesis, antimycobacterial activities and phototoxic evaluation of 5H-thiazolo[3,2-a]quinoline-4-carboxylic acid derivatives.

  2008cites this paper
• Epidemiology and evolution of quinolone resistance.

  2008cites this paper
• Inhibition of DNA gyrase activity by Mycobacterium smegmatis MurI.

  2008cites this paper
• Inhibition of DNA gyrase activity by Mycobacteriumsmegmatis

  2007cites this paper
• Molecular Cloning of Apicoplast-Targeted Plasmodium falciparum DNA Gyrase Genes: Unique Intrinsic ATPase Activity and ATP-Independent Dimerization of PfGyrB Subunit

  2007cites this paper
• Dissection of the nucleotide cycle of B. subtilis DNA gyrase and its modulation by DNA.

  2007cites this paper
• Streptococcus pneumononiae gyrase ATPase: development and validation of an assay for inhibitor discovery and characterization.

  2007cites this paper
• Antimycobacterial activities of novel 1-(cyclopropyl/tert-butyl/4-fluorophenyl)-1,4-dihydro- 6-nitro-4-oxo-7-(substituted secondary amino)-1,8-naphthyridine-3-carboxylic acid.

  2007cites this paper
• A complex of DNA gyrase and RNA polymerase fosters transcription in Mycobacterium smegmatis.

  2006cites this paper
• In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class

  2006cites this paper
• Glutamate racemase from Mycobacterium tuberculosis inhibits DNA gyrase by affecting its DNA-binding

  2006cites this paper
• The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA)

  2006influential citation
• First functional characterization of a singly expressed bacterial type II topoisomerase: the enzyme from Mycobacterium tuberculosis.

  2006cites this paper
• Characterization of the DNA-binding domain and identification of the active site residue in the ‘Gyr A’ half of Leishmania donovani topoisomerase II

  2005cites this paper
• The structural basis for substrate specificity in DNA topoisomerase IV.

  2005cites this paper
• Synthesis and antimycobacterial evaluation of various 7-substituted ciprofloxacin derivatives.

  2005cites this paper
• An atypical type II topoisomerase from Mycobacterium smegmatis with positive supercoiling activity

  2005cites this paper
• A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism

  2005influential citation
• A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates.

  2005cites this paper
• Regulation of DNA topology in mycobacteria

  2004cites this paper
• Mu-Like Prophage Strong Gyrase Site Sequences: Analysis of Properties Required for Promoting Efficient Mu DNA Replication

  2004cites this paper
• Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489.

  2004influential citation
• Molekularbiologische und biochemische Untersuchungen zu Resistenzmechanismen der Aminocoumarinantibiotika-Produzenten und zur Amidsynthetase CouL aus Streptomyces rishiriensis DSM 40489

  2003cites this paper
• Resistance Genes of Aminocoumarin Producers: Two Type II Topoisomerase Genes Confer Resistance against Coumermycin A1 and Clorobiocin

  2003cites this paper
• An orphangyrB in theMycobacterium smegmatis genome uncovered by comparative genomics

  2002cites this paper