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Autoantibodies to the β 1-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction

M. Segovia,S. Reina,E. Borda,L. Sterin‐Borda

Published 2011 in ISRN Dentistry

ABSTRACT

The presence of serum autoantibodies in periodontitis (P) patients against β 1-adrenoceptor (β 1-AR), using cardiac membranes or a synthetic β 1-AR peptide corresponding to the second extracellular loop of human β 1-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-β 1-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-β 1-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the β 1-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-β 1-AR autoantibodies in alteration of myocardial contractility.

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