Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2015-07-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1512081112PMID 26216992PMCID PMC4538633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus.

  2014cited by this paper
• An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

  2014cited by this paper
• Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.

  2014cited by this paper
• Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

  2014cited by this paper
• AIRE acetylation and deacetylation: effect on protein stability and transactivation activity

  2014cited by this paper
• Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

  2013cited by this paper
• Aire’s plant homeodomain(PHD)-2 is critical for induction of immunological tolerance

  2013cited by this paper
• Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

  2013cited by this paper
• Master transcription factors and mediator establish super-enhancers at key cell identity genes.

  2013cited by this paper
• Two faces of BRD4

  2013cited by this paper
• Selective inhibition of tumor oncogenes by disruption of super-enhancers.

  2013cited by this paper
• HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

  2013cited by this paper
• Super-enhancers in the control of cell identity and disease.

  2013cited by this paper
• Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting.

  2013cited by this paper
• SnapShot: Transcription regulation: pausing.

  2013cited by this paper
• Unmodified Histone H3K4 and DNA-Dependent Protein Kinase Recruit Autoimmune Regulator to Target Genes

  2012cited by this paper
• Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition*

  2012cited by this paper
• Fast gapped-read alignment with Bowtie 2

  2012cited by this paper
• Place your BETs: the therapeutic potential of bromodomains.

  2012cited by this paper
• Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection

  2012cited by this paper
• Identification of a Novel Series of BET Family Bromodomain Inhibitors: Binding Mode and Profile of I‐BET151 (GSK1210151A).

  2012cited by this paper
• Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).

  2012cited by this paper
• Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

  2012cited by this paper
• Autoimmune regulator is acetylated by transcription coactivator CBP/p300.

  2012influential reference
• Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

  2011cited by this paper
• Bromodomains as therapeutic targets

  2011cited by this paper
• Selective inhibition of BET bromodomains

  2010cited by this paper
• Distinct factors control histone variant H3.3 localization at specific genomic regions.

  2010cited by this paper
• c-Myc regulates transcriptional pause release.

  2010cited by this paper
• Aire's partners in the molecular control of immunological tolerance.

  2010cited by this paper
• Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

  2009cited by this paper
• Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution*

  2009cited by this paper
• Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

  2009cited by this paper
• The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

  2008cited by this paper
• Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

  2008cited by this paper
• The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression.

  2008cited by this paper
• Lysine acetylation: codified crosstalk with other posttranslational modifications.

  2008cited by this paper
• AIRE's CARD Revealed, a New Structure for Central Tolerance Provokes Transcriptional Plasticity*

  2008cited by this paper
• Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA

  2008influential reference
• DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity

  2008influential reference
• Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity

  2008cited by this paper
• Model-based Analysis of ChIP-Seq (MACS)

  2008cited by this paper
• AIRE Recruits P-TEFb for Transcriptional Elongation of Target Genes in Medullary Thymic Epithelial Cells

  2007cited by this paper
• Regulation of Transcript Elongation through Cooperative and Ordered Recruitment of Cofactors*

  2007cited by this paper
• An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

  2007cited by this paper
• The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation

  2006cited by this paper
• The cellular mechanism of Aire control of T cell tolerance.

  2005cited by this paper
• Chromosomal clustering of genes controlled by the aire transcription factor.

  2005cited by this paper
• APECED‐causing mutations in AIRE reveal the functional domains of the protein

  2004cited by this paper
• Aire regulates negative selection of organ-specific T cells

  2003cited by this paper
• Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

  2002cited by this paper
• The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein*

  2000cited by this paper
• Site-directed mutagenesis by overlap extension using the polymerase chain reaction.

  1989influential reference

• Systematic and proactive evaluation of AIRE missense variant effects

  2025cites this paper
• Thymic epithelial cells amplify epigenetic noise to promote immune tolerance

  2025cites this paper
• Thymic Interferons: A Little Goes a Long Way

  2025cites this paper
• Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus

  2025cites this paper
• Interplay between BET Proteins and the Pre-Replication Complex Unveils Therapeutic Vulnerabilities in Cancer

  2025cites this paper
• AT1, a small molecular degrader of BRD4 based on proteolysis targeting chimera technology alleviates renal fibrosis and inflammation in diabetic nephropathy.

  2025cites this paper
• AIRE's Complex Role Beyond Promiscuous Gene Expression

  2025cites this paper
• The Autoimmune Regulator (AIRE) Gene, The Master Activator of Self-Antigen Expression in the Thymus.

  2025cites this paper
• FEZF2 and AIRE1: An Evolutionary Trade-off in the Elimination of Auto-reactive T Cells in the Thymus

  2024cites this paper
• Where AIRE we now? Where AIRE we going?

  2024cites this paper
• A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

  2024cites this paper
• Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity

  2024cites this paper
• BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma

  2024cites this paper
• Thymic Mimetic Cells: Ontogeny as Immunology.

  2024cites this paper
• Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasis

  2024cites this paper
• Novel Insights into the Autoimmunity from the Genetic Approach of the Human Disease.

  2024cites this paper
• Aire in Autoimmunity

  2024influential citation
• Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

  2023cites this paper
• Revisiting Aire and tissue-restricted antigens at single-cell resolution

  2023cites this paper
• The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance

  2022influential citation
• Thymic self-antigen expression for immune tolerance and surveillance

  2022cites this paper
• Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells.

  2022cites this paper
• Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance *

  2022cites this paper
• Fezf2 and Aire1 evolutionary trade-off in negative selection of T cells in the thymus

  2022cites this paper
• Phylogeny, Structure, Functions, and Role of AIRE in the Formation of T-Cell Subsets

  2022cites this paper
• Structure-guided discovery of novel potent and efficacious proteolysis targeting chimera (PROTAC) degrader of BRD4.

  2021cites this paper
• The BET family in immunity and disease

  2021cites this paper
• Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

  2021cites this paper
• miR-155 exerts posttranscriptional control of autoimmune regulator (Aire) and tissue-restricted antigen genes in medullary thymic epithelial cells

  2021cites this paper
• Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers

  2021influential citation
• AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression *

  2021cites this paper
• BRD4 in physiology and pathology: ‘‘BET’’ on its partners

  2021cites this paper
• Genetics of Autoimmune Regulator (AIRE) and Clinical Implications in Childhood

  2021cites this paper
• Transcriptional and epigenetic regulation in thymic epithelial cells *

  2021cites this paper
• BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

  2020cites this paper
• Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

  2020cites this paper
• Chd4 choreographs self-antigen expression for central immune tolerance

  2020cites this paper
• Aire Gene Influences the Length of the 3′ UTR of mRNAs in Medullary Thymic Epithelial Cells

  2020cites this paper
• Brd/BET Proteins Influence the Genome-Wide Localization of the Kaposi’s Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus Major Latency Proteins

  2020cites this paper
• Regulation of Pol II transcriptional response to DNA damage by RBM7 and P-TEFb

  2020cites this paper
• Genetics of Autoimmune Regulator (AIRE) and Clinical Implications in Childhood

  2019cites this paper
• BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells

  2019cites this paper
• Bromodomain-containing protein 4–independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB

  2018cites this paper
• mTECs Aire on the side of caution

  2018cites this paper
• Update on Aire and thymic negative selection

  2018cites this paper
• [P-TEFb and Brd4: actors of the transcription pause release as therapeutical targets].

  2018cites this paper
• SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

  2018cites this paper
• Twenty Years of AIRE

  2018cites this paper
• Rapid chromatin repression by Aire provides precise control of immune tolerance

  2018cites this paper
• The transcriptional regulator Aire binds to and activates super-enhancers

  2017cites this paper
• Thymic Epithelial Cells.

  2017cites this paper
• Chemical probes targeting epigenetic proteins: Applications beyond oncology

  2017cites this paper
• DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes

  2017cites this paper
• AIRE: From promiscuous molecular partnerships to promiscuous gene expression

  2016cites this paper
• Erythropoiesis provides a BRD's eye view of BET protein function.

  2016cites this paper
• AIRE expands: new roles in immune tolerance and beyond

  2016cites this paper
• Bromodomain 4: a cellular Swiss army knife

  2016cites this paper
• Autoimmune regulator and self‐tolerance – molecular and clinical aspects

  2016influential citation
• FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator)*

  2016influential citation