Inhibition of lipid accumulation by the ethyl acetate fraction of Distylium racemosum in vitro and in vivo

Hye-Ran Kim,Bo-Kyoung Jung,Min-Ho Yeo,W. Yoon,Kyung-Soo Chang

Published 2019 in Toxicology Reports

ABSTRACT

Highlights • Lipid accumulation in the 3T3-L1 cells were inhibited by treatment with DRE.• The expression levels of SREBP1c, PPARγ, C/EBPα, and FAS were decreased by DRE.• HFD induced fat mice showed lower rate of weight gain and serum TG level through DRE administration.

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