Establishment of gene‐edited pigs expressing human blood‐coagulation factor VII and albumin for bioartificial liver use

Bioartificial livers (BALs) are considered as a solution to bridge patients with acute liver failure to liver transplantation or to assist in spontaneous recovery for patients with end‐stage liver disease. Pig is the best donor of hepatocytes for BALs in clinical trials, because metabolic and detoxification function of its liver are close to human. However, using pig hepatocytes for BALs remains controversial for safety concern owing to nonhuman proteins secretion. Herein, we attempt to establish modified pigs expressing humanized liver proteins, blood‐coagulation factor VII (F7), and albumin (ALB). These pigs should also be porcine endogenous retrovirus subtype C (PERV‐C) free so that their ability of transmitting PERV to human could be diminished seriously.

• Publication year

  2019

• Venue

  Journal of Gastroenterology and Hepatology

• Publication date

  2019-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/jgh.14666PMID 30884543
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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