Positive Selection as a Developmental Progression Initiated by αβTCR Signals that Fix TCR Specificity prior to Lineage Commitment

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Immunity

• Publication date

  1999-03-01

• Fields of study

  Biology

• Identifiers
  DOI 10.1016/S1074-7613(00)80030-8
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• A molecular map of T cell development.

  1998cited by this paper
• Two distinct pathways of positive selection for thymocytes.

  1998cited by this paper
• How Many Thymocytes Audition for Selection?

  1997cited by this paper
• Discrimination between maintenance‐ and differentiation‐inducing signals during initial and intermediate stages of positive selection

  1997cited by this paper
• Positive selection of thymocytes bearing αβ T cell receptors

  1997cited by this paper
• Structure and function of the pre-T cell receptor.

  1997cited by this paper
• Heterogeneous Expression of Recombination Activating Genes and Surface CD5 in CD3low CD4+CD8+ Thymocytes

  1996cited by this paper
• The c-kit+ maturation pathway in mouse thymic T cell development: lineages and selection.

  1996cited by this paper
• Lineage Commitment in the Thymus: Only the Most Differentiated (TCRhibcl-2hi) Subset of CD4+CD8+Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis

  1996cited by this paper
• Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

  1995cited by this paper
• A role for CD5 in TCR-mediated signal transduction and thymocyte selection.

  1995cited by this paper
• Development and selection of T cells: facts and puzzles.

  1995cited by this paper
• Selective events in T cell development.

  1994cited by this paper
• Generation of mature T cell populations in the thymus: CD4 or CD8 down‐regulation occurs at different stages of thymocyte differentiation

  1994cited by this paper
• Small CD4+8+TCRlow thymocytes contain precursors of mature T cells

  1994cited by this paper
• An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

  1994cited by this paper
• Small cortical thymocytes are subject to positive selection

  1994cited by this paper
• Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection

  1994cited by this paper
• Regulation of thymocyte development through CD3. I. Timepoint of ligation of CD3 epsilon determines clonal deletion or induction of developmental program

  1993cited by this paper
• Normal sequence of phenotypic transitions in one cohort of 5-bromo-2'-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression.

  1993cited by this paper
• A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

  1993cited by this paper
• Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.

  1993cited by this paper
• T cell receptor β chain dimers on immature thymocytes from normal mice

  1993cited by this paper
• Positive Selection of Immature αβ T Cells

  1993cited by this paper
• Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes

  1993cited by this paper
• Another view of the selective model of thymocyte selection.

  1993cited by this paper
• CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection.

  1993cited by this paper
• Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

  1993cited by this paper
• Profound block in thymocyte development in mice lacking p56lck

  1992cited by this paper
• Exclusion and inclusion of a and T cell receptor alleles

  1992cited by this paper
• Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

  1992cited by this paper
• Post-transcriptional regulation of early T cell development by T cell receptor signals.

  1992cited by this paper
• Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice.

  1991cited by this paper
• Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice

  1991cited by this paper
• The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post- selection intermediates leading to mature T cells

  1991cited by this paper
• Delayed thymocyte development induced by augmented expression of p56lck

  1991cited by this paper
• Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

  1991cited by this paper
• Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.

  1991cited by this paper
• Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

  1991cited by this paper
• Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4.

  1990cited by this paper
• Kinetics of mature T-cell development in the thymus.

  1990cited by this paper
• Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

  1990cited by this paper
• T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages

  1990cited by this paper
• The generation and fate of thymocytes.

  1990cited by this paper
• The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

  1989cited by this paper
• Intrathymic maturation of murine T lymphocytes from CD8+ precursors.

  1989cited by this paper
• Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

  1988cited by this paper
• T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

  1988cited by this paper
• Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

  1988cited by this paper
• Accessories or coreceptors?

  1988cited by this paper
• Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

  1988cited by this paper
• Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors

  1986cited by this paper
• Role of Self Antigens in the Selection of the Developing T Cell Repertoire

  1986cited by this paper
• Progress in immunology V

  1985cited by this paper

• Altered Innate-like T Cell Development in Vα14-Jα18 TCRα Transgenic Mice.

  2020cites this paper
• The Role of the Thymus in the Immune Response.

  2019cites this paper
• TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes

  2019cites this paper
• Attenuated T Cell Responses to a High-Potency Ligand In Vivo

  2010cites this paper
• Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection.

  2010cites this paper
• Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC

  2007cites this paper
• Overexpression of Cellular Prion Protein Induces an Antioxidant Environment Altering T Cell Development in the Thymus1

  2006cites this paper
• Altering T Cell Development in the Thymus Induces an Antioxidant Environment Overexpression of Cellular Prion Protein

  2006cites this paper
• Analyse de la recombinaison des gènes TCRAD : Réarrangements radio-induits et structure des jonctions signal

  2005cites this paper
• CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

  2004cites this paper
• CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision.

  2004cites this paper
• Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo

  2004cites this paper
• Restricting Zap70 Expression to CD4+CD8+ Thymocytes Reveals a T Cell Receptor–dependent Proofreading Mechanism Controlling the Completion of Positive Selection

  2003cites this paper
• Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice

  2003cites this paper
• During T Cell Development Thymocytes with Shorter TCRB CDR3 Selection: Selection of CD4 Single-Positive A Molecular Marker for Thymocyte-Positive

  2002cites this paper
• A Molecular Marker for Thymocyte-Positive Selection: Selection of CD4 Single-Positive Thymocytes with Shorter TCRB CDR3 During T Cell Development1

  2002cites this paper
• CD5‐mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain

  2002cites this paper
• The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.

  2001cites this paper
• Sensory Adaptation in Naive Peripheral CD4 T Cells

  2001cites this paper
• Dynamic Tuning of T Cell Reactivity by Self-Peptide–Major Histocompatibility Complex Ligands

  2001cites this paper
• Distinct Mechanisms Contribute to Generate and Change the CD4:CD8 Cell Ratio During Thymus Development: A Role for the Notch Ligand, Jagged1

  2001cites this paper
• Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength.

  2001cites this paper
• T Cell Development in TCRb Enhancer-Deleted Mice: Implications for ab T Cell Lineage Commitment and Differentiation

  2000cites this paper
• Alterations during Positive Selection in the Thymus of nackt CD4‐Deficient Mice

  2000cites this paper
• CD8 Coreceptor Extinction in Signaled CD4+CD8+ Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes

  2000cites this paper
• Pairing of Vβ6 with certain Vα2 family members prevents T cell deletion by Mtv-7 superantigen

  2000cites this paper
• Thymocyte Maturation: Selection for In-Frame TCR α-Chain Rearrangement Is Followed by Selection for Shorter TCR β-Chain Complementarity-Determining Region 31

  2000cites this paper
• Regulation of pre-T-cell development

  2000cites this paper
• Preferential proliferation and differentiation of double-positive thymocytes into CD8(+) single-positive thymocytes in a novel cell culture medium.

  2000cites this paper
• T Cell Development in TCRβ Enhancer-Deleted Mice: Implications for αβ T Cell Lineage Commitment and Differentiation1

  2000cites this paper
• Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8(+) T cell differentiation in the thymus.

  2000cites this paper
• From basic immunobiology to the upcoming WHO-classification of tumors of the thymus. The Second Conference on Biological and Clinical Aspects of Thymic Epithelial Tumors and related recent developments.

  1999cites this paper