von Willebrand factor self-association on platelet GpIbalpha under hydrodynamic shear: effect on shear-induced platelet activation.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Blood

• Publication date

  2010-11-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1182/blood-2010-02-269266PMID 20696943PMCID PMC2981547
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress.

  2009cited by this paper
• Fluid shear induces conformation change in human blood protein von Willebrand factor in solution.

  2009cited by this paper
• Platelet response heterogeneity in thrombus formation

  2009cited by this paper
• Platelet Adhesion under Flow

  2009cited by this paper
• Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

  2009cited by this paper
• Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ibalpha shedding.

  2009cited by this paper
• Application of fluorescence spectroscopy to quantify shear-induced protein conformation change.

  2009cited by this paper
• Biological effects of dynamic shear stress in cardiovascular pathologies and devices

  2008cited by this paper
• Systems‐level studies of glycosyltransferase gene expression and enzyme activity that are associated with the selectin binding function of human leukocytes

  2008cited by this paper
• Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13

  2008cited by this paper
• Immune complexes formed following the binding of anti-platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion.

  2008cited by this paper
• Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress.

  2008cited by this paper
• Shear-induced unfolding triggers adhesion of von Willebrand factor fibers

  2007cited by this paper
• Two novel monoclonal antibodies to VWFA3 inhibit VWF‐collagen and VWF‐platelet interactions

  2007cited by this paper
• Shear-induced Disulfide Bond Formation Regulates Adhesion Activity of von Willebrand Factor*

  2007cited by this paper
• Signaling and regulation of the platelet glycoprotein Ib–IX–V complex

  2007cited by this paper
• Soluble plasma-derived von Willebrand factor assembles to a haemostatically active filamentous network

  2007cited by this paper
• Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival.

  2006cited by this paper
• von Willebrand factor A1 domain can adequately substitute for A3 domain in recruitment of flowing platelets to collagen

  2006cited by this paper
• Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura.

  2006cited by this paper
• Solution Structure of Human von Willebrand Factor Studied Using Small Angle Neutron Scattering*

  2006cited by this paper
• Analysis on the molecular species and concentration of circulating ADAMTS13 in Blood.

  2006cited by this paper
• Shielding of the A1 Domain by the D′D3 Domains of von Willebrand Factor Modulates Its Interaction with Platelet Glycoprotein Ib-IX-V*

  2006cited by this paper
• The von Willebrand factor self‐association is modulated by a multiple domain interaction

  2005cited by this paper
• Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice.

  2005cited by this paper
• How to Roll an Endothelial Cigar: The Biogenesis of Weibel‐Palade Bodies

  2004cited by this paper
• Hydrodynamic forces applied on intercellular bonds, soluble molecules, and cell-surface receptors.

  2004cited by this paper
• Acquired von Willebrand syndrome in aortic stenosis.

  2003cited by this paper
• Aspects of hydrodynamic shear regulating shear-induced platelet activation and self-association of von Willebrand factor in suspension.

  2003cited by this paper
• Selectin-Like Kinetics and Biomechanics Promote Rapid Platelet Adhesion in Flow: The GPIbα-vWF Tether Bond

  2002cited by this paper
• Selectin-like kinetics and biomechanics promote rapid platelet adhesion in flow: the GPIb/spl alpha/-vWF tether bond

  2002cited by this paper
• Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers.

  2002cited by this paper
• ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.

  2002cited by this paper
• Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura

  2001cited by this paper
• Functional self-association of von Willebrand factor during platelet adhesion under flow

  2001influential reference
• Improvement of von Willebrand Factor Proteolysis After Prostacyclin Infusion in Severe Pulmonary Arterial Hypertension

  2000cited by this paper
• Enhanced shear-induced platelet aggregation in acute myocardial infarction.

  1999cited by this paper
• Identification of Domains Responsible for von Willebrand Factor Type VI Collagen Interaction Mediating Platelet Adhesion under High Flow*

  1999cited by this paper
• Platelets and shear stress.

  1996cited by this paper
• Characterization of the Unique Mechanism Mediating the Shear-dependent Binding of Soluble von Willebrand Factor to Platelets (*)

  1995cited by this paper
• Shear‐Induced Platelet Aggregation in Cerebral Ischemia

  1994cited by this paper
• Shear stress enhances the proteolysis of von Willebrand factor in normal plasma.

  1994cited by this paper
• Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin).

  1994cited by this paper
• Low shear stress can initiate von Willebrand factor-dependent platelet aggregation in patients with type IIB and platelet-type von Willebrand disease.

  1993cited by this paper
• An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis.

  1991cited by this paper
• Structure of the glycoprotein Ib.IX complex from platelet membranes.

  1988cited by this paper
• Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa.

  1987cited by this paper
• Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation.

  1986cited by this paper
• Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura.

  1982cited by this paper

• Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

  2025cites this paper
• Immobilized IgG-containing immune complexes require platelets to recruit neutrophils during inflammation

  2025cites this paper
• Electrochemical VWF Biosensors Based on Two-Step Synthesized rGO@AuNPs Nanocomposites for Early Prediction of ECMO Bleeding Complications.

  2025cites this paper
• Platelet collagen receptors and their role in modulating platelet adhesion patterns and activation on alternatively processed collagen substrates.

  2024cites this paper
• Hemodynamic activation of von Willebrand factor in children with congenital heart diseases

  2024cites this paper
• Von Willebrand factor and hematogenous cancer metastasis under flow

  2024cites this paper
• Biomechanical activation of blood platelets via adhesion to von Willebrand factor studied with mesoscopic simulations

  2023cites this paper
• The interplay between adsorption and aggregation of von Willebrand factor chains in shear flows

  2022cites this paper
• Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain.

  2022cites this paper
• Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging

  2022cites this paper
• Direct Impact of Human Platelets on the Development of Transplant Arteriosclerosis

  2021cites this paper
• Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association.

  2021cites this paper
• Involvement of platelet-derived VWF in metastatic growth of melanoma in the brain

  2021cites this paper
• Physical forces regulating hemostasis and thrombosis: Vessels, cells, and molecules in illustrated review

  2021cites this paper
• Microfluidic assay of antiplatelet agents for inhibition of shear-induced platelet adhesion and activation.

  2020cites this paper
• Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis

  2020cites this paper
• IolR, a negative regulator of the myo-inositol metabolic pathway, inhibits cell autoaggregation and biofilm formation by downregulating RpmA in Aeromonas hydrophila

  2020cites this paper
• Hypergravity Activates a Pro-Angiogenic Homeostatic Response by Human Capillary Endothelial Cells

  2020cites this paper
• Role of Autophagy in Von Willebrand Factor Secretion by Endothelial Cells and in the In Vivo Thrombin-Antithrombin Complex Formation Promoted by the HIV-1 Matrix Protein p17

  2020cites this paper
• In silico identification of mimicking molecule(s) triggering von Willebrand factor in human: a molecular drug target for regulating coagulation pathway

  2020cites this paper
• Biomechanics in thrombus formation from direct cellular simulations.

  2020cites this paper
• ABCG2/BCRP: variants, transporter interaction profile of substrates and inhibitors

  2019cites this paper
• Acquired Von Willebrand Syndrome (AVWS) in cardiovascular disease: a state of the art review for clinicians

  2019cites this paper
• Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine

  2019cites this paper
• Thrombotic Thrombocytopenic Purpura and Related Thrombotic Microangiopathies

  2019cites this paper
• von Willebrand factor self-association is regulated by the shear-dependent unfolding of the A2 domain.

  2019cites this paper
• The role of PI3K/Akt signaling pathway in non-physiological shear stress-induced platelet activation.

  2019cites this paper
• Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura.

  2019cites this paper
• Thrombomodulin and interleukin 6 as potential biomarkers of endothelial dysfunction and inflammation after renal transplant

  2018cites this paper
• The physical spacing between the von Willebrand factor D'D3 and A1 domains regulates platelet adhesion in vitro and in vivo

  2018cites this paper
• Inflammation, von Willebrand factor, and ADAMTS13.

  2018cites this paper
• 14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.

  2018cites this paper
• Mechanotransduction in blood cells

  2017cites this paper
• Thrombosis in diabetes: a shear flow effect?

  2017cites this paper
• Application of microfluidic devices in studies of thrombosis and hemostasis

  2017cites this paper
• Identification of extant vertebrate Myxine glutinosa VWF: evolutionary conservation of primary hemostasis.

  2017cites this paper
• A Comprehensive, Open-source Platform for Mass Spectrometry-based Glycoproteomics Data Analysis*

  2017cites this paper
• Segmental outflow of aqueous humor in mouse and human

  2017cites this paper
• Thrombus Formation at High Shear Rates.

  2017cites this paper
• Role of calcium in regulating the intra- and extracellular cleavage of von Willebrand factor by the protease ADAMTS13.

  2017cites this paper
• Free thiol groups in von Willebrand factor (VWF) are required for its full function under physiological flow conditions.

  2016cites this paper
• The bvg‐repressed gene brtA, encoding biofilm‐associated surface adhesin, is expressed during host infection by Bordetella bronchiseptica

  2016cites this paper
• Regulation of VWF expression, and secretion in health and disease

  2016cites this paper
• High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion.

  2016cites this paper
• The effect of biomechanical and biochemical regulators on the expression of Factor VIII and von Willebrand Factor in endothelial cells

  2016cites this paper
• Acquired von Willebrand syndrome associated with left ventricular assist device.

  2016cites this paper
• Relative Contributions of von Willebrand Factor and Platelets in High Shear

  2016cites this paper
• A simple method for activating the platelets used in microfluidic platelet aggregation tests: Stirring-induced platelet activation

  2016cites this paper
• A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma

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• The functions of the A 1 A 2 A 3 domains in von Willebrand factor include multimerin 1 binding SHORTENED TITLE ( 50 Characters ) : VWF A 1 A 2 A 3 domains support MMRN 1 binding

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• The Functions of the A1A2A3 Domains in Von Willebrand Factor Include Multimerin 1 Binding

  2016cites this paper
• Role of fluid shear stress in regulating VWF structure, function and related blood disorders

  2015influential citation
• In microfluidico: Recreating in vivo hemodynamics using miniaturized devices

  2015cites this paper
• Interaction of von Willebrand factor with platelets and the vessel wall

  2015cites this paper
• Detection of Plasma Protease Activity Using Microsphere-Cytometry Assays with E. coli Derived Substrates: VWF Proteolysis by ADAMTS13

  2015cites this paper
• Examining platelet adhesion via Stokes flow simulations and microfluidic experiments.

  2015cites this paper
• Fluid Mechanics of Blood Clot Formation.

  2015cites this paper
• Effect of cold storage on shear-induced platelet aggregation and clot strength

  2014cites this paper
• Platelet GpIbα Binding to von Willebrand Factor Under Fluid Shear: Contributions of the D'D3‐Domain, A1‐Domain Flanking Peptide and O‐Linked Glycans

  2014cites this paper
• [Activators, receptors and signal transduction pathways of blood platelets].

  2014cites this paper
• Mechanisms of Platelet Activation by Biomaterials and Fluid Shear Flow

  2013cites this paper
• Enhanced shear‐induced platelet aggregation due to low‐temperature storage

  2013cites this paper
• Platelet motion near a vessel wall or thrombus surface in two-dimensional whole blood simulations.

  2013cites this paper
• Migration distance-based platelet function analysis in a microfluidic system.

  2013cites this paper
• Thrombotic Thrombocytopenic Purpura and Related Thrombotic Microangiopathies

  2013cites this paper
• Flow Mechanotransduction Response in Endothelial Cell Monolayers and Platelets

  2013cites this paper
• Biomechanics of haemostasis and thrombosis in health and disease: from the macro- to molecular scale

  2013cites this paper
• Chapter 20 – Platelet Thrombus Formation in Flowing Blood

  2013cites this paper
• The unfolded von Willebrand factor response in bloodstream: the self-association perspective

  2012cites this paper
• Structure and function of von Willebrand factor

  2012cites this paper
• von Willebrand factor (VWF) propeptide binding to VWF D (cid:1) D3 domain attenuates platelet activation and adhesion

  2012cites this paper
• Endothelial molecules decipher the mechanisms and functional pathways in antibody-mediated rejection.

  2012cites this paper
• Multiscale prediction of patient-specific platelet function under flow.

  2012cites this paper
• Direct Observation of von Willebrand Factor Elongation and Fiber Formation on Collagen During Acute Whole Blood Exposure to Pathological Flow

  2012cites this paper
• von Willebrand factor (VWF) propeptide binding to VWF D'D3 domain attenuates platelet activation and adhesion.

  2012cites this paper
• Formation of platelet‐binding von Willebrand factor strings on non‐endothelial cells

  2012cites this paper
• Blood platelet biochemistry.

  2012cites this paper
• Mechanisms of Platelet Capture Under Very High Shear

  2011cites this paper
• Design Principles for Microfluidic Biomedical Diagnostics in Space

  2011cites this paper
• β2‐Glycoprotein I: evolution, structure and function

  2011cites this paper
• Escherichia coli-derived von Willebrand factor-A2 domain fluorescence/Förster resonance energy transfer proteins that quantify ADAMTS13 activity.

  2011cites this paper
• Platelets at work in primary hemostasis.

  2011cites this paper
• VWF self-association: more bands for the buck.

  2010cites this paper