Synthesis and antidiabetic activity of β-acetamido ketones

Abstract This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin–West reaction for the synthesis of β -acetamido ketones. The method has several advantages such as requiring only mild conditions and a low concentration of catalyst. Screening of 19 β -acetamido ketones for antidiabetic activity in vitro showed that their activity as peroxisome proliferator-activated receptor (PPAR) agonists and as dipeptidyl peptidase 4 (DPP-IV) inhibitors was fairly weak.

• Publication year

  2011

• Venue

  Acta Pharmaceutica Sinica B

• Publication date

  2011-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.APSB.2011.06.006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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