Discovery and evaluation of potent, cysteine-based α4β1 integrin antagonists

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Bioorganic & Medicinal Chemistry Letters

• Publication date

  2000-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0960-894X(00)00146-3
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Small molecule antagonists of α4 integrins: novel drugs for asthma

  1999cited by this paper
• Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

  1997cited by this paper
• The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction.

  1995cited by this paper
• Integrin- Ligand Binding: Do integrins use a ‘MIDAS touch’ to grasp an Asp?

  1995cited by this paper
• A novel cyclic pentapeptide inhibits alpha 4 beta 1 and alpha 5 beta 1 integrin-mediated cell adhesion.

  1993cited by this paper
• Integrins: versatility, modulation, and signaling in cell adhesion.

  1992cited by this paper
• The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.

  1991cited by this paper
• Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules

  1991cited by this paper
• VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site.

  1990cited by this paper
• Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin

  1989cited by this paper

• Modeling the molecular basis for α4β1 integrin antagonism.

  2011cites this paper
• 2,3-Diphenylpropionic acids as potent VLA-4 antagonists.

  2005cites this paper
• N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists.

  2002cites this paper
• Specific and dual antagonists of α4β1 and α4β7 integrins

  2002cites this paper
• Chapter 7. Antagonists of VILA-4

  2002cites this paper
• VLA-4 antagonists

  2002cites this paper
• Discovery and Evaluation of Potent, Cysteine-Based α4β1 Integrin Antagonists.

  2000cites this paper