Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol

BackgroundCognitive dysfunction is common among depressed patients. However, the pattern and magnitude of impairment during episodes of major depressive disorder (MDD) through to clinical remission remains unclear. Heterogeneity of depressive patients and the lack of longitudinal studies may account for contradictory results in previous research.Methods/DesignThis longitudinal study will analyze cognitive differences between CORE-defined melancholic depressed patients (n = 60) and non-melancholic depressed patients (n = 60). A comprehensive clinical and cognitive assessment will be performed at admission and after 6 months. Cognitive dysfunction in both groups will be longitudinally compared, and the persistence of cognitive impairment after clinical remission will be determined.DiscussionThe study of neuropsychological dysfunction and the cognitive changes through the different phases of depression arise a wide variety of difficulties. Several confounding variables must be controlled to determine if the presence of depression could be considered the only factor accounting for group differences.

• Publication year

  2010

• Venue

  BMC Psychiatry

• Publication date

  2010-06-17

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1186/1471-244X-10-48PMID 20565743PMCID 2896936
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A longitudinal study of cognitive function in melancholic and non-melancholic subtypes of major depressive disorder.

  2010cited by this paper
• Major Depressive Disorder in recovery and neuropsychological functioning: effects of selective serotonin reuptake inhibitor and dual inhibitor depression treatments on residual cognitive deficits in patients with Major Depressive Disorder in recovery.

  2010cited by this paper
• Cognitive impairment in major depression.

  2010cited by this paper
• A meta-analysis of depression severity and cognitive function.

  2009cited by this paper
• Cognitive deficits in the euthymic phase of unipolar depression.

  2009cited by this paper
• Construct validity of the Trail Making Test: Role of task-switching, working memory, inhibition/interference control, and visuomotor abilities

  2009cited by this paper
• Cognitive functioning in a population-based sample of young adults with a history of non-psychotic unipolar depressive disorders without psychiatric comorbidity.

  2008cited by this paper
• Measuring melancholia: the utility of a prototypic symptom approach

  2008cited by this paper
• Restoring melancholia in the classification of mood disorders.

  2008influential reference
• Neurocognitive Function Following Remission in Major Depressive Disorder: Potential Objective Marker of Response?

  2007cited by this paper
• Neuropsychological Impairment in Major Depression: Its Nature, Origin and Clinical Significance

  2007influential reference
• Defining melancholia: the primacy of psychomotor disturbance

  2007cited by this paper
• Perceived parental rearing of bipolar offspring

  2007cited by this paper
• Neurocognitive impairment in euthymic young adults with bipolar spectrum disorder and recurrent major depressive disorder.

  2006cited by this paper
• Cognitive testing toward the future: The example of Semantic Verbal Fluency (ANIMALS)

  2006cited by this paper
• Differential patterns of psychomotor functioning in unmedicated melancholic and nonmelancholic depressed patients.

  2004cited by this paper
• Getting What You Ask For: On the Selectivity of Depression Rating Scales

  2003cited by this paper
• Long-lasting cognitive impairment in unipolar major depression: a 6-month follow-up study.

  2003cited by this paper
• Psychopathological dimensions of depression: a factor study of the 17-item Hamilton depression rating scale in unipolar depressed outpatients.

  2002cited by this paper
• Biological risk factors in late life depression.

  2002cited by this paper
• Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients.

  2002cited by this paper
• Vascular basis of late-onset depressive disorder

  2002cited by this paper
• Cognitive deficits in depression: Possible implications for functional neuropathology

  2001influential reference
• Melancholia: Definitions, Risk Factors, Personality, Neuroendocrine Markers and Differential Antidepressant Response

  2001cited by this paper
• Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery.

  2000cited by this paper
• Hippocampal Remodeling and Damage by Corticosteroids: Implications for Mood Disorders

  1999cited by this paper
• Cognitive function in depression: a distinct pattern of frontal impairment in melancholia?

  1999cited by this paper
• Melancholia: A disorder of movement and mood

  1997cited by this paper
• Melancholia: A Disorder of Movement and Mood: Contents

  1996cited by this paper
• Diurnal variation of mood and neuropsychological function in major depression with melancholia.

  1994cited by this paper
• Defining Melancholia: Properties of a Refined Sign-Based Measure

  1994influential reference
• Cognitive dysfunctions in recovered melancholic patients.

  1994cited by this paper
• Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence.

  1991cited by this paper
• Cognitive Deficit in the Depressed Elderly: A Review of Some Basic Unresolved Issues

  1986cited by this paper
• “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician

  1975influential reference
• Word fluency and brain damage

  1967cited by this paper
• A RATING SCALE FOR DEPRESSION

  1960influential reference

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  2020cites this paper
• Suicidal risk and executive functions in major depressive disorder: a study protocol

  2019cites this paper
• Regional cerebral metabolism alterations affect resting-state functional connectivity in major depressive disorder.

  2018cites this paper
• Subtypes of depression and their overlap in a naturalistic inpatient sample of major depressive disorder

  2018cites this paper
• From autophagy to mitophagy: the roles of P62 in neurodegenerative diseases

  2017cites this paper
• Metabolomic biosignature differentiates melancholic depressive patients from healthy controls

  2016cites this paper
• Statistic Analysis of Medical Depression Index

  2016cites this paper
• Cognitive function after clinical remission in patients with melancholic and non-melancholic depression: a 6 month follow-up study.

  2015cites this paper
• Cognitive impairments and depression: a critical review.

  2015cites this paper
• Clinical Patterns and Treatment Outcome in Patients with Melancholic, Atypical and Non-Melancholic Depressions

  2012cites this paper
• Hygienic-dietary recommendations for major depression treatment: Study protocol of a randomized controlled trial

  2012cites this paper
• Neurocognitive Disorders in DSM-V: Forensic Perspective

  2010cites this paper
• Melancholic Depression and its Relationship to Cognitive Decline

  2010cites this paper